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ClinicalTrials.gov public records Last synced Oct 17, 2026, 5:27 AM EDT

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Showing 1–24 of 259 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Stepped-Care Clear all
Recruiting Not applicable Interventional

Stepped Care Treatment for Anxiety Resilience

NCT07228143
View directory record Official record
Conditions
Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), Separation Anxiety Disorder, Specific Phobia, Obsessive Compulsive Disorder (OCD), Panic Disorder (With or Without Agoraphobia)
Interventions
Relaxation and Mentorship Training (RMT), Stepped Care Targeting Exposure and Parenting for Anxiety (STEP-A)
Behavioral
Lead sponsor
Andrew Wiese
Other
Eligibility
7 Years to 17 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional

Sleep To Reduce Incident Depression Effectively

NCT03322774
View directory record Official record
Conditions
Insomnia, Primary, Major Depressive Disorder, Rumination
Interventions
digital Cognitive Behavioral Therapy for Insomnia, face-to-face Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education Control
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
1,237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 17, 2026, 5:27 AM EDT
Recruiting Not applicable Interventional

UMMS Sepsis Early Prediction Score (SEPSys) and RESCUE Score Combined Clinical Trial

NCT06779617
View directory record Official record
Conditions
Sepsis, Patient Deterioration
Interventions
SEPSys, RESCUE
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
150,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
8
States / cities
Baltimore, Maryland • Bel Air, Maryland • Easton, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Not yet recruiting Not applicable Interventional

The Agenda-Setting for Kidney Disease Trial

NCT07024953
View directory record Official record
Conditions
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
Interventions
Chronic Kidney Disease Structured Agenda-Setting Tool
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stepped Care for Youth Living With HIV

NCT03109431
View directory record Official record
Conditions
HIV, Mental Health, Illicit Substance Use, Sexually Transmitted Infections (STI)
Interventions
Level 1, Level 2, Level 3
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
12 Years to 24 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California • New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Oct 17, 2026, 5:27 AM EDT
Active, not recruiting Not applicable Interventional

A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems

NCT05632770
View directory record Official record
Conditions
PTSD, Physical Injury
Interventions
Stepped Collaborative Care, American College of Surgeons (ACS) Required Screening and Referral (Usual Care)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
424 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Active, not recruiting Not applicable Interventional

PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children

NCT03860168
View directory record Official record
Conditions
Critical Illness
Interventions
PICU Up!
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
0 Years to 24 Years
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Active, not recruiting Not applicable Interventional

Multilevel Interventions to Increase Adherence to Lung Cancer Screening

NCT05747443
View directory record Official record
Conditions
Lung Cancer, Lung Cancer Screening
Interventions
Stepped Reminders, Patient Education
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
50 Years to 78 Years
Enrollment
1,837 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 17, 2026, 5:27 AM EDT
Not yet recruiting Not applicable Interventional

Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart Failure

NCT07714239
View directory record Official record
Conditions
Heart Failure, Heart Failure, Systolic
Interventions
Pharmacist/Cardiologist Virtual Team Digital Consultation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Terminated Not applicable Interventional

ASK-PrEP (Assistance Services Knowledge-PrEP)

NCT05934877
View directory record Official record
Conditions
Substance Use Disorders, HIV
Interventions
PrEP navigation + text messaging, Standard of Care, Contingency Management
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older · Male only
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional

Planned CORR: Planned Care for Obesity and Risk Reduction

NCT01134029
View directory record Official record
Conditions
Obesity, Cardiovascular Risk Factors
Interventions
Stepped Care
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
25 Years to 70 Years
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Dec 5, 2014 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Results available

A Comparative Effectiveness Trial of Optimal Patient-Centered Care

NCT02274688
View directory record Official record
Conditions
Post Traumatic Concerns, Post Traumatic Stress Disorder, Depression and Suicide Ideation, Alcohol and Drug Use
Interventions
Stepped Care Management
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
14 Years and older
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 21, 2017 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stepped-care Telehealth for Young Children With ASD

NCT04467073
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
Online RIT
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
16 Months to 60 Months
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 10, 2020 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interventions for Smoking Among Persons in Recovery

NCT00714896
View directory record Official record
Conditions
Smoking Cessation
Interventions
Stepped-Care, Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Oct 17, 2026, 5:27 AM EDT
Not listed Not applicable Interventional

Peer Wellness Enhancement For Patients With Serious Mental Illness and High Medical Costs

NCT03673852
View directory record Official record
Conditions
Chronic Medical Condition
Interventions
WE Harambee, Behavioral Health Home Enrollment
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2022 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Results available

Stepped-Care Telehealth for Distress in Cancer Survivors

NCT03060096
View directory record Official record
Conditions
Anxiety, Depressive Symptoms, Sleep Disturbance, Recurrent Disease, Fatigue, Quality of Life, Cancer
Interventions
Severe Anxiety/depression: High Intensity Stepped Care, Moderate Anxiety/depression: Low Intensity Stepped care, Enhanced Usual Care Control
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
166
States / cities
Fort Smith, Arkansas • Fresno, California • Modesto, California + 129 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional

Confidential IPV Screening Tool

NCT06284148
View directory record Official record
Conditions
Violence, Domestic
Interventions
Screening for intimate partner violence, Assessment and referral
Diagnostic Test · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 49 Years
Enrollment
19,655 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 17, 2026, 5:27 AM EDT
Not yet recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

A Stepped Care Approach to Treating Tobacco Use in Rural Veterans

NCT04501016
View directory record Official record
Conditions
Tobacco Cessation
Interventions
Tailored behavioral counseling, Tobacco cessation pharmacotherapy
Behavioral · Drug
Lead sponsor
Iowa City Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 6, 2020 · Synced Oct 17, 2026, 5:27 AM EDT
Enrolling by invitation Not applicable Interventional

Collaborative Approach to Reach Everyone With Familial Hypercholesterolemia (CARE-FH)

NCT05284513
View directory record Official record
Conditions
Familial Hypercholesterolemia
Interventions
FH diagnosis program, Implementation strategy package: Develop and implement tools for quality monitoring, Implementation strategy package: Develop educational materials, Implementation strategy package: Conduct educational outreach visits, Implementation strategy package: Intervene with clinicians and patients to enhance, Behavioral (e.g., Psychotherapy, Lifestyle Counseling) Implementation strategy package: Identify and prepare champions Clinical lipid champions, Implementation strategy package: Audit and provide feedback, Implementation strategy package: Stage implementation scale up
Behavioral
Lead sponsor
Geisinger Clinic
Other
Eligibility
26 Years and older
Enrollment
532 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Multiple Locations, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 17, 2026, 5:27 AM EDT
Not listed No phase listed Observational

Use of a Predictive Analytics Algorithm to Optimize Weaning of Inotropes Following Pediatric Cardiac Surgery

NCT04600700
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Clinical Decision support system (CDSS) for inotrope weaning
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
1 Day to 365 Days
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2021 · Synced Oct 17, 2026, 5:27 AM EDT
Recruiting Not applicable Interventional

Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

NCT07024498
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
care coordination implementation strategies
Other
Lead sponsor
University of California, Davis
Other
Eligibility
14 Years and older
Enrollment
3,492 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
4
States / cities
El Centro, California • Irvine, California • Placerville, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Computer Assisted Cognitive Behavior Therapy for Obsessive Compulsive Disorder: A Comprehensive Stepped-Care Approach

NCT01522287
View directory record Official record
Conditions
Obsessive Compulsive Disorder
Interventions
Computer-Assisted Cognitive Behavior Therapy (BT STEPS)
Behavioral
Lead sponsor
Center for Psychological Consultation
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 14, 2014 · Synced Oct 17, 2026, 5:27 AM EDT
Completed Not applicable Interventional Results available

Stepped-Care Cognitive-Behavioral Treatment for Youth With ASD and Anxiety

NCT03720795
View directory record Official record
Conditions
Cognitive Behavioral Therapy, Autism Spectrum Disorder, Anxiety Disorders, Obsessive-Compulsive Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Specific Phobia
Interventions
Stepped Care CBT
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
4 Years to 14 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Oct 17, 2026, 5:27 AM EDT
Terminated Phase 1 Interventional Results available

Piloting Acute Care to Primary Care Linkage of Safety Net Patients

NCT01347541
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications, Standard Care Control
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 10, 2021 · Synced Oct 17, 2026, 5:27 AM EDT