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ClinicalTrials.gov public records Last synced Sep 17, 2026, 1:56 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Intervention: Subarachnoid block Clear all
Completed Phase 4 Interventional Results available

Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty

NCT02284386
View directory record Official record
Conditions
Pain
Interventions
Bupivacaine SNB, EXPAREL Infiltration
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Sheffield, Alabama • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 7, 2021 · Synced Sep 17, 2026, 1:56 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Intrathecal Hydromorphone for Post-cesarean Delivery Pain - a Dose Finding Study

NCT01943565
View directory record Official record
Conditions
Healthy, Pain, Pregnancy
Interventions
Hydromorphone 25mcg, Hydromorphone 50mcg, Hydromorphone 100mcg, spinal anesthesia
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery

NCT02354833
View directory record Official record
Conditions
Effects of; Anesthesia, in Labor and Delivery
Interventions
Phenylephrine, Norepinephrine
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Jan 3, 2017 · Synced Sep 17, 2026, 1:56 AM EDT
Withdrawn Not applicable Interventional

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

NCT01232400
View directory record Official record
Conditions
Subarachnoid Hemorrhage
Interventions
Esmolol
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 7, 2015 · Synced Sep 17, 2026, 1:56 AM EDT
Completed No phase listed Observational

PVI for Prediction of Spinal Induced Hypotension

NCT01967914
View directory record Official record
Conditions
Spinal Induced Hypotension
Interventions
PVI
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 16, 2015 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional Results available

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

NCT02789410
View directory record Official record
Conditions
Analgesia, Obstetrical, Obstetric Surgical Procedures
Interventions
Morphine, Hydromorphone
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Sep 17, 2026, 1:56 AM EDT
Terminated Early Phase 1 Interventional

Liposomal Bupivacaine (Exparel) in Sarcomas

NCT03867188
View directory record Official record
Conditions
Soft Tissue Sarcoma, Soft Tissue Tumor, Soft Tissue Tumor and/or Sarcoma
Interventions
Liposomal Bupivacaine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neonatal Acid-Base Status After C Section With Maternal Tilt vs. Supine

NCT02243423
View directory record Official record
Conditions
Aortocaval Compression, Fetal Acidosis
Interventions
SUPINE, TILT
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

ED90 for Hyperbaric Bupivacaine in Super Obese Parturients

NCT03781388
View directory record Official record
Conditions
Obesity, Morbid, Spinal Anesthesia, Cesarean Delivery
Interventions
Bupivacaine
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Remote Ischemic Pre-conditioning in Subarachnoid Hemorrhage

NCT02381522
View directory record Official record
Conditions
Brain Aneurysms
Interventions
Remote Ischemic Pre-conditioning, Sham RIPC
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

NCT02980926
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee, Pain Management, Early Ambulation, Ambulatory Surgical Procedures
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
40 Years to 90 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
West Bloomfield, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2017 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional Results available

Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores

NCT02840240
View directory record Official record
Conditions
Pain
Interventions
Gabapentin enacarbil, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Sep 17, 2026, 1:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Thromboelastography to Assess Age-Related Coagulation Differences in Patients Undergoing Cesarean Delivery

NCT01416454
View directory record Official record
Conditions
Thrombophilia
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Sep 17, 2026, 1:56 AM EDT
Terminated Not applicable Interventional Results available

Continuous Labor Epidural Catheter for Tubal Ligation Study

NCT00898443
View directory record Official record
Conditions
Tubal Ligation, Bilateral Tubal Ligation
Interventions
Epidural anesthetic, Spinal anesthetic
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 45 Years · Female only
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 6, 2012 · Synced Sep 17, 2026, 1:56 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pre-post Spinal Popliteal Block

NCT05354791
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
Not listed
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Palpation and ACCURO for Placing Spinal in C-section

NCT03090295
View directory record Official record
Conditions
Anesthesia,Obstetrical
Interventions
Palpation and Accuro
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 17, 2026, 1:56 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

NCT07614906
View directory record Official record
Conditions
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Audiovisual Distraction for Patients Undergoing Total Knee or Hip Replacement Surgery

NCT03191838
View directory record Official record
Conditions
Anesthesia
Interventions
Audiovisual Distraction
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 10, 2020 · Synced Sep 17, 2026, 1:56 AM EDT
Withdrawn Not applicable Interventional

Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension

NCT02101047
View directory record Official record
Conditions
Complications; Cesarean Section, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Interventions
Phenylephrine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 7, 2017 · Synced Sep 17, 2026, 1:56 AM EDT
Recruiting Phase 3 Interventional

Opioid-Sparing Joint Replacement

NCT07348627
View directory record Official record
Conditions
Pain Management, Opioid Consumption
Interventions
Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 17, 2026, 1:56 AM EDT
Not listed Not applicable Interventional

International Subarachnoid Aneurysm Trial II

NCT01668563
View directory record Official record
Conditions
Intracranial Hemorrhage Ruptured Aneurysm
Interventions
surgical management, Endovascular management
Procedure
Lead sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Other
Eligibility
18 Years and older
Enrollment
1,724 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Sep 17, 2026, 1:56 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Ondansetron Use for Preventing Pruritus in Patients Undergoing Cesarean Section

NCT06297499
View directory record Official record
Conditions
Pruritus Caused by Drug
Interventions
Ondansetron 8mg
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Phase 4 Interventional

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

NCT06291727
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Sep 17, 2026, 1:56 AM EDT
Completed Not applicable Interventional

Measurement of Hemodynamic Variables Under Spinal Anesthesia With Varied Positioning

NCT02883075
View directory record Official record
Conditions
Pregnancy, Anesthesia
Interventions
Supine position, Right lateral position, Left lateral position
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older · Female only
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Sep 17, 2026, 1:56 AM EDT