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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Substance use disorder screening Clear all
Enrolling by invitation No phase listed Observational

Comparing Immune Activation and Latent HIV Reservoir Size Between People Living With HIV on Tenofovir-containing Versus NRTI-free ART

NCT05584397
View directory record Official record
Conditions
HIV-1-infection, HIV Disease Progression, Inflammation, HIV
Interventions
Venipuncture, Targeted physical medical exam, Urine pregnancy test, Anoscopy, Esophagogastroduodenoscopy (EGD)
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Enrolling by invitation Not applicable Interventional

Pre-Pilot (R61) WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD

NCT07665502
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders, Intimate Partner Violence (IPV), Stress Disorders, Post-Traumatic, Domestic Violence, Medication for Opioid Use Disorder (MOUD), Post Traumatic Stress Disorder PTSD
Interventions
Pre-Pilot WINGS++++
Behavioral
Lead sponsor
Dawn A. Goddard-Eckrich
Other
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
New York, New York • Newburgh, New York
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation and Treatment of Substance Abuse in Veterans With PTSD Disability Claims

NCT01597856
View directory record Official record
Conditions
Attendance at Treatment, PTSD, Substance Use, and Attendance at Treatment
Interventions
SBIRT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
346 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
2
States / cities
West Haven, Connecticut • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 9, 2026, 1:11 AM EDT
Active, not recruiting Not applicable Interventional

Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care

NCT04601064
View directory record Official record
Conditions
HIV Infections, Substance Use Disorders, Mental Health Disorder, Addiction, Opioid Use, Drug Use
Interventions
Collaborative Care Model
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 99 Years
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional

Primary Care-Based Interventions to Reduce Alcohol Use Among HIV Patients

NCT01671501
View directory record Official record
Conditions
HIV, Acquired Immunodeficiency Syndrome, Alcoholism, Alcoholic Intoxication, Substance-Related Disorders
Interventions
Motivational Interviewing, Email Feedback, Usual Care
Behavioral · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 100 Years
Enrollment
614 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 9, 2018 · Synced Sep 9, 2026, 1:11 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Advancing Adolescent Screening and Brief Intervention Protocols in Primary Care Settings

NCT01523444
View directory record Official record
Conditions
Substance Abuse
Interventions
computer-assisted Screening & Brief Advice, computer-assisted Screening & Brief Advice Plus
Behavioral
Lead sponsor
Treatment Research Institute
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2023 · Synced Sep 9, 2026, 1:11 AM EDT
Recruiting Not applicable Interventional

reSET for the Treatment of Stimulant Use in HIV Clinics: Care Optimization Supporting Treatment Adherence (COSTA)

NCT05958017
View directory record Official record
Conditions
Stimulant Use Disorder, People Living With HIV
Interventions
reSET, Standard of care
Behavioral · Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 90 Years · Male only
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

NCT06552741
View directory record Official record
Conditions
Substance Use Disorder, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2047
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Phase 3 Interventional

Multidisciplinary Approach to Reduce Injury and Substance Abuse

NCT01048359
View directory record Official record
Conditions
Drug Abuse
Interventions
Brief advice, Brief Intervention plus Booster, Brief Intervention
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional

Upper Extremity Life Care Specialist (LCS)

NCT05422014
View directory record Official record
Conditions
Upper Extremity Trauma
Interventions
Life Care Specialist (LCS)
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Results available

Pilot Randomized Controlled Trial (RCT): Remote SBIRT Vs. In-Person SBIRT

NCT04630249
View directory record Official record
Conditions
Pregnancy, Substance Use, Depression, Anxiety
Interventions
Listening to Women and Pregnant and Postpartum People
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 41 Years · Female only
Enrollment
415 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 17, 2024 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Results available

Usability Testing for the Reward-based Technology to Improve OUD Treatment

NCT05159362
View directory record Official record
Conditions
Opioid-use Disorder, Contingency Management, Medication for Opioid-use Disorder
Interventions
Software Application
Other
Lead sponsor
Q2i, LLC
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 29, 2023 · Synced Sep 9, 2026, 1:11 AM EDT
Enrolling by invitation Not applicable Interventional

Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

NCT07527871
View directory record Official record
Conditions
Substance Use (Drugs, Alcohol)
Interventions
ED-SMART intervention, Substance use information
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years and older
Enrollment
650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional

Screening and Brief Intervention for Substance Misuse Following Traumatic Brain Injury

NCT02129361
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Adapted Screening and Brief Intervention (Adapted SBI), Screening & Education Attention Control
Behavioral
Lead sponsor
Jennifer Bogner, PhD, ABPP
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2021 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional

An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder

NCT06102200
View directory record Official record
Conditions
Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
Interventions
CBT4CBT, RC, Sandard of care
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Creating VIP Corps to Reduce Maternal Deaths

NCT06089109
View directory record Official record
Conditions
Maternal Morbidity and Mortality
Interventions
The Big 3, Implementation and Effectiveness of VIP Corps Training
Behavioral
Lead sponsor
Ann Coker
Other
Eligibility
18 Years to 30 Years
Enrollment
2,800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 2, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study of a Multi-Component Intervention for Black Men Who Have Sex With Men

NCT00951249
View directory record Official record
Conditions
HIV Infections
Interventions
Referral of Partners, Screening for STIs and counseling, Peer health care system navigators, Enhanced counseling
Behavioral
Lead sponsor
HIV Prevention Trials Network
Network
Eligibility
18 Years and older · Male only
Enrollment
1,553 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
8
States / cities
Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 4 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2022 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Results available

SUPER Study (Substance Use and PTSD Treatment Effectiveness Research Study)

NCT00265564
View directory record Official record
Conditions
Substance Use Disorders, Posttraumatic Stress Disorder
Interventions
Modified Seeking Safety integrated into std outpatient SUD care, Standard outpatient SUD care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older · Male only
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2020 · Synced Sep 9, 2026, 1:11 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Routine Clinical Screening for Substance Use Disorders in the Emergency Room Setting

NCT01661465
View directory record Official record
Conditions
Substance Use
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 85 Years
Enrollment
9,212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional

Substance Use Screening and Prevention for Adolescents in Pediatric Primary Care

NCT03074877
View directory record Official record
Conditions
Substance Use
Interventions
Family Check-Up
Behavioral
Lead sponsor
RTI International
Other
Eligibility
9 Years to 13 Years
Enrollment
722 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia

NCT05471921
View directory record Official record
Conditions
Alcohol and Substance-Related Mental Disorders
Interventions
SBIRT, Treatment as usual
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
15 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 9, 2026, 1:11 AM EDT
Terminated Early Phase 1 Interventional

Brief Intervention and Referral to Treatment With Substance Use Disorders in the Emergency Room Setting

NCT01661517
View directory record Official record
Conditions
Substance Use
Interventions
Motivational interviewing and referral to treatment
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
5,271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 17, 2016 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Results available

Data-driven Identification for Substance Misuse

NCT03833804
View directory record Official record
Conditions
Substance Use, Substance Abuse, Substance-Related Disorders
Interventions
Processing of clinical notes in the EHR data collected during routine care
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 89 Years
Enrollment
64,996 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 9, 2026, 1:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use Electronic Spanish Platform

NCT03879785
View directory record Official record
Conditions
Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use
Interventions
Screening
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2019 · Synced Sep 9, 2026, 1:11 AM EDT