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Conditions: Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
Interventions: Standing or upright tilt, Microneurography, QSweat, neck cuff stimulation, phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine, clonidine,yohimbine,metoclopramide,alpha-methyldopa, BodPod, Eye exam, Sleep study, Pain response testing, Metabolic chamber, Brain function studies, Bicycle Exercise Test; Procedure · Device · Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 12 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome
Interventions: Secretin, MRI, Tumor marker gene test with CA19-9; Drug · Diagnostic Test · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 9,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2029
U.S. locations: 9
States / cities: New Haven, Connecticut • Baltimore, Maryland • Boston, Massachusetts + 5 more

Conditions: Mastectomy, Mammaplasty, Breast Reconstruction
Interventions: REVOLVE Advanced Adipose System, LipoGrafter, Viality; Device · Procedure
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 135 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Wound Infection
Interventions: Prevena, Traditional Dressing; Device
Lead sponsor: Englewood Hospital and Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Englewood, New Jersey

Conditions: Tracheostomy
Interventions: 3mL of normal saline from the pink sodium chloride bullet, Sham Comparator of 3mL normal saline; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Insufficient Breast Milk Syndrome
Interventions: Breast Pump suction pattern; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older · Female only
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Pulmonary Embolism Acute
Interventions: Anticoagulation, mechanical aspiration thrombectomy; Drug · Device
Lead sponsor: Penumbra Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 19
States / cities: Tucson, Arizona • Los Angeles, California • Lakeland, Florida + 14 more

Conditions: Traumatic Pneumothorax
Interventions: Chest tube suction; Procedure
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Anastomotic Leaks, Hartmanns Stump Leakage
Interventions: Endo-SPONGE; Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 10
States / cities: Sacramento, California • Orlando, Florida • Weston, Florida + 7 more

Conditions: Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
Interventions: Tranexamic Acid 100 MG/ML, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Intratympanic Steroid Injection, Idiopathic Sudden Sensorineural Hearing Loss, Meniere Disease
Interventions: Tetracaine 5% drops, Phenol 90% concentration; Drug
Lead sponsor: Our Lady of the Lake Hospital; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Diabetic Foot Ulcers
Interventions: Powered Suction Pump (VAC Freedom), Powered Suction Pump, MWT; Device
Lead sponsor: KCI USA, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 2
States / cities: Columbus, Ohio • San Antonio, Texas

Conditions: Surgical Site Infection, Cesarean Section; Infection
Interventions: Abdominal Closure Bundle; Procedure
Lead sponsor: Abington Memorial Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 850 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Abington, Pennsylvania

Conditions: Chronic Venous Hypertension With Ulcer
Interventions: ActiVAC System, Compression therapy; Device · Other
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Microbiota, SIBO
Interventions: Capillary Endoscopy Aspiration Catheter, Endoscopy Aspiration Catheter; Device
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 85 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Obstructive Sleep Disorder, Obstructive Sleep Apnea, Tonsillar Hypertrophy
Interventions: Micropolysaccharide Hemospheres (Arista), Electrocautery (Monopolar suction cautery); Device
Lead sponsor: Massachusetts Eye and Ear Infirmary; Other
Eligibility: 5 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Interventions: blood drawing, fiberoptic bronchoscopy; Procedure
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 80 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Surgical Site Infection, Groin Infections
Interventions: Negative Pressure Pressure Wound Therapy, Standard Wound Care; Device · Procedure
Lead sponsor: Henry Ford Health System; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Stroke, Acute, Cerebral Infarction
Interventions: Endovascular Thrombectomy, Trevo Retriever, Solitaire™ FR Revascularization Device, Penumbra thrombectomy system, Covidien MindFrame Capture Revascularization Device; Procedure · Device
Lead sponsor: Gregory W Albers; Other
Eligibility: 18 Years to 90 Years
Enrollment: 182 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 40
States / cities: Birmingham, Alabama • Fresno, California • La Jolla, California + 26 more

Conditions: Amputation, Diabetes Complications, Leg Injuries, Traumatic Amputation
Interventions: Pe-Lite and sleeve suspension socket, Total Surface bearing a socket with a sleeve suspension but without suction, Total surface bearing suction socket with a pin lock suspension, Total surface bearing suction socket with a sleeve suspension, Vacuum-assisted socket system (Harmony System, Otto Bock); Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Respiratory Insufficiency, Pneumonia, Atelectasis
Interventions: Bronchoscope reusable (Storz 8402 2x), Bronchoscope disposable (aScope 4); Device
Lead sponsor: University of Louisville; Other
Eligibility: 18 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Louisville, Kentucky

Conditions: Postpartum Haemorrhage (PPH), PPH, Postpartum Hemorrhage (Primary)
Interventions: Alma System; Device
Lead sponsor: ResQ Medical Ltd; Other
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Brooklyn, New York

Conditions: Perforated Appendicitis
Interventions: Irrigation, No Irrigation; Procedure
Lead sponsor: Children's Mercy Hospital Kansas City; Other
Eligibility: 1 Month to 17 Years
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Transfemoral Amputation
Interventions: Northwestern University Flexible Subischial Suction Socket (NU-FlexSIS); Device
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 84 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Houston, Texas • Seattle, Washington

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The Pathophysiology of Orthostatic Hypotension

The Cancer of the Pancreas Screening-5 CAPS5)Study

A Comparative Analysis of REVOLVE, LipoGrafter, and Viality in Autologous Fat Grafting During Breast Surgery

Negative Pressure Therapy for Groin Wounds

Normal Saline Use With Suctioning

Comparison of Breast Pump Suction Patterns

Comparison of Two Pulmonary Embolism Treatments

Duration of Chest Tube Suction in Traumatic Pneumothorax

Endo-SPONGE for Treatment of Anastomotic or Hartmann's Stump Leakages in Lower Pelvic Area

Tranexamic Acid in Adult Spinal Deformity Surgery

Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injection

A Trial Examining Cellular Energetics Related to Various Wound Treatment Therapies

Abdominal Closure Bundle to Reduce Surgical Site Infection in Patients Undergoing C-sections. Cesarean Section Lead to Reduction in Surgical Site Infection? - A Randomized Controlled Trial

ActiV.A.C.+ Compression Therapy Versus Compression Therapy Alone for the Treatment of Chronic Venous Ulcerations

Capillary Endoscopy Aspiration Catheter

Topical Microporous Polysaccharide Hemospheres Versus Electrocautery for Control of Pediatric Post-Tonsillectomy Bleeding

Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD

Negative Pressure Wound Therapy for Surgical Site Infection Prevention in Common Femoral Artery Exposure

Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3

Study to Determine if Different Prosthetic Sockets Effect How Much Oxygen is in the Tissue of Lower Limb Amputees While They Are Walking

Evaluation of a Disposable Flexible Bronchoscope, aScope IV

EVE TRIAL , ALMA SYSTAM

Irrigation Versus No Irrigation for Perforated Appendicitis

Sub-Ischial Socket for Transfemoral Amputation and Lower Mobility