Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 6, 2026, 9:09 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 129 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Surgical Valve Replacement Clear all

Conditions: Aortic Valve Disease, Aortic Stenosis
Interventions: Perceval valve, other stented biological valve; Device
Lead sponsor: Corcym S.r.l; Industry
Eligibility: 18 Years and older
Enrollment: 914 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 5
States / cities: Indianapolis, Indiana • Portland, Maine • Cleveland, Ohio + 2 more

Conditions: Heart Valve Diseases
Interventions: Trifecta valve; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 245 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 6
States / cities: Minneapolis, Minnesota • Rochester, Minnesota • Asheville, North Carolina + 3 more

Conditions: Heart Failure
Interventions: Collection of discarded heart tissue; Procedure
Lead sponsor: AdventHealth Translational Research Institute; Other
Eligibility: 19 Years to 89 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale, PIVSD - Post Infarct Muscular Ventricular Septal Defect, Valvular Heart Disease
Interventions: Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2039
U.S. locations: 13
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more

Conditions: Aortic Stenosis
Interventions: SAPIEN S3 valve; Device
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: Not listed
Enrollment: 1,822 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 55
States / cities: La Jolla, California • Los Angeles, California • Palo Alto, California + 46 more

Conditions: Aortic Valve Disease
Interventions: Aortic Valve Replacement; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 9
States / cities: Los Angeles, California • Madera, California • Sacramento, California + 6 more

Conditions: Severe Aortic Stenosis
Interventions: Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI), Surgical Aortic Valve Replacement (SAVR); Device
Lead sponsor: Medtronic Cardiovascular; Industry
Eligibility: Not listed
Enrollment: 1,453 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2019
U.S. locations: 45
States / cities: Phoenix, Arizona • Los Angeles, California • Mountain View, California + 35 more

Conditions: This Study is Being Conducted to Collect Echocardiographic Data to Test the Lumify Ultrasound With Hemodynamic Automation Device
Interventions: Ultrasound imaging; Diagnostic Test
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Aortic Stenosis, Disorder of Prosthetic Cardiac Valve, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Hypertrophic Cardiomyopathy, Tricuspid Valve Insufficiency
Interventions: Blood Draw; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years and older
Enrollment: 378 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2020
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Heart Defect, Congenital
Interventions: Xeltis Bioabsorbable Pulmonary Valved Conduit; Device
Lead sponsor: Xeltis; Industry
Eligibility: 2 Years to 21 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2026
U.S. locations: 7
States / cities: Los Angeles, California • Aurora, Colorado • Hollywood, Florida + 4 more

Conditions: Mitral Valve Insufficiency
Interventions: Mitral valve surgery; Procedure
Lead sponsor: Atlantic Health System; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Morristown, New Jersey

Conditions: Aortic Stenosis, Cardiac Valve Replacement Complication, Fragility
Interventions: Not listed
Lead sponsor: Jewish General Hospital; Other
Eligibility: 70 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Boston, Massachusetts • Durham, North Carolina

Conditions: Aortic Valve Stenosis
Interventions: Echocardiography, Computed tomography, Magnetic resonance imaging, Blood biomarkers, Stress echocardiography; Other
Lead sponsor: Laval University; Other
Eligibility: 21 Years to 90 Years
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2024
U.S. locations: 2
States / cities: Rochester, Minnesota • Pittsburgh, Pennsylvania

Conditions: Mitral Annular Calcification, Mitral Stenosis, Mitral Regurgitation, Mitral Valve Disease
Interventions: Transseptal ViMAC; Device
Lead sponsor: Mayra Guerrero; Other
Eligibility: 18 Years and older
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 16
States / cities: Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 12 more

Conditions: Aortic Valve Stenosis
Interventions: Transcatheter Aortic Valve Replacement; Procedure
Lead sponsor: The Society of Thoracic Surgeons; Other
Eligibility: 18 Years and older
Enrollment: 16,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2035
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Mitral Valve Insufficiency, Coronary Artery Disease
Interventions: MV Repair, MV Replacement, CABG; Other
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 368 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2027
U.S. locations: 16
States / cities: Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more

Conditions: Mitral Valve Disease
Interventions: Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Mayra Guerrero; Other
Eligibility: 22 Years and older
Enrollment: 91 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 15
States / cities: Phoenix, Arizona • Los Angeles, California • Washington D.C., District of Columbia + 9 more

Conditions: Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Interventions: Patients scheduled to undergo aortic valve replacement or aortic surgery at BIDMC will be approached for participation in this study.; Procedure
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 20 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Mitral Regurgitation, Mitral Valve Disease, Mitral Valve Failure, Mitral Disease, Valve Heart Disease, Valve Disease, Heart
Interventions: Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Caisson Interventional LLC; Industry
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2025
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Antimicrobial Prophylaxis
Interventions: daptomycin 6 mg/kg IV; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Mitral Regurgitation
Interventions: Cardiovalve Transfemoral Mitral Valve; Device
Lead sponsor: Cardiovalve Ltd.; Industry
Eligibility: 18 Years to 84 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Atlanta, Georgia • New York, New York

Conditions: Coronary Artery Disease
Interventions: Coronary artery bypass grafting (CABG), Valve replacement; Procedure
Lead sponsor: University of Miami; Other
Eligibility: 50 Years to 75 Years
Enrollment: 43 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions: Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline; Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Open Heart Surgery Patients
Interventions: Cardiac Surgery; Procedure
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 90 Years and older
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005
U.S. locations: 1
States / cities: New York, New York

Search by objective public record fields.

Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement

Post-Approval Study Protocol of the St. Jude Medical Trifecta Valve

Identifying Targets of Maladaptive Metabolic Responses in Heart Failure

Abbott Structural Heart Device Registry

PARTNER II Trial: S3iCAP

SJM Masters HP 15mm Rotatable Mechanical Heart Valve as Aortic Valve Replacement Therapy

Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement

Testing Automated Echocardiography

Biomarkers in Aortic Stenosis - B.A.S.S.

Xeltis Bioabsorbable Pulmonary Valved Conduit Pivotal Study

MRI as a Predictor of Outcomes in Patients Undergoing Mitral Valve Surgery

Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)

Long Term Follow Up for CTSN Mitral Valve Repair Studies

Mitral Implantation of TRAnscatheter vaLves

Identification of Genetic Causes of Calcific Aortic Valve Disease

Caisson Transcatheter Mitral Valve Replacement (TMVR)

A Pilot Study of Daptomycin for Antimicrobial Prophylaxis

Cardiovalve Transfemoral Mitral Valve System

Epicardial Fat in Coronary Artery Disease

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

Quality of Life After Open Heart Surgery in Older Patients