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Showing 1–24 of 157 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: TBI - Intervention Group Clear all
Not listed Not applicable Interventional

Brain Injury Therapy of Exercise and Enriched Environment

NCT03256643
View directory record Official record
Conditions
Brain Injuries
Interventions
Exercise, Delayed Exercise, Exercise and enrichment
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Taylor, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 25, 2020 · Synced Sep 3, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

NCT06734026
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients
Interventions
Cafe Therapy
Behavioral
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Problem Solving Training for Care Partners of Adults With Traumatic Brain Injury

NCT03739450
View directory record Official record
Conditions
Care Partners of Patients With Traumatic Brain Injury (TBI)
Interventions
Problem Solving Training (PST), Education
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
4
States / cities
East Hanover, New Jersey • Edison, New Jersey • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 3, 2026, 11:50 AM EDT
Terminated Not applicable Interventional

Effects of an Interdisciplinary Fitness and Social Engagement Intervention

NCT03160313
View directory record Official record
Conditions
TBI (Traumatic Brain Injury)
Interventions
InFuSE, Patient Education/Group Discussion
Behavioral
Lead sponsor
Washington D.C. Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 28, 2024 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Phase 1 Interventional

Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

NCT01471067
View directory record Official record
Conditions
Blood And Marrow Transplantation, Leukemia, Lymphoma, Transplantation Infection, Transplantation, Bone Marrow
Interventions
Melphalan, Fludarabine, Mycophenolate mofetil, Tacrolimus, Cord Blood Infusion, Rituximab, ATG, Busulfan, Clofarabine, Total Body Irradiation (TBI)
Drug · Procedure · Radiation
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
1 Year to 80 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Phase 2 Interventional Results available

Sumatriptan as Treatment for Post-traumatic Headache

NCT01854385
View directory record Official record
Conditions
Post-traumatic Headache
Interventions
Sumatriptan 100 mg
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

The Brave Initiative: Bringing Rehabilitation to American Veterans in an Enriched Environment

NCT02339220
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Constraint-Induced Movement Therapy (CIMT), Lakeshore Enriched Fitness Training (LEFT), standard Transfer Package (sTP), enhanced Transfer Package (eTP)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 90 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Rural Veterans With Post-traumatic Stress Disorder (PTSD) And Comorbid Mild Traumatic Brain Injury (TBI): A Feasibility Study

NCT01278316
View directory record Official record
Conditions
Post-Traumatic Stress Disorders, Traumatic Brain Injury
Interventions
Control, Cognitive Training
Behavioral
Lead sponsor
Michael E. DeBakey VA Medical Center
Federal
Eligibility
20 Years to 40 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 21, 2018 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Home-based Arm and Hand Exercise to Improve Upper Limb Function After Traumatic Brain Injury

NCT03401645
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Wrist Alarm, Home-based Arm and Hand Exercise
Other · Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
20 Years to 60 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Sep 3, 2026, 11:50 AM EDT
Not yet recruiting Not applicable Interventional

Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis

NCT07492602
View directory record Official record
Conditions
Stroke, Traumatic Brain Injury, Multiple Sclerosis
Interventions
Functional Electrical Stimulation, Normal care
Device
Lead sponsor
Casa Colina Hospital and Centers for Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pomona, California
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS

NCT01816061
View directory record Official record
Conditions
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Interventions
Experimental - COMPASS, Control - COMPASS
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 55 Years
Enrollment
91 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Sep 3, 2026, 11:50 AM EDT
Not listed Not applicable Interventional

Investigating How Sleep After Training Can Affect the Learning of a Motor Skill in Individuals With Brain Injury

NCT04810442
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Nap
Other
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 22, 2021 · Synced Sep 3, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Pragmatic Rehabilitation Intervention: The Active Rehab Study

NCT05320822
View directory record Official record
Conditions
Concussion, Brain
Interventions
Active Rehab (Group 2), Progressive Return to Activity (Group 1)
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Fort Liberty, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study

NCT04925453
View directory record Official record
Conditions
Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries, Brain Injuries, Traumatic, Neurocognitive Dysfunction, Attention Impaired, Memory Impairment, Mild Traumatic Brain Injury, Mild Cognitive Impairment
Interventions
active tDCS and cognitive training intervention, sham tDCS and cognitive training intervention
Combination Product
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 55 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 3, 2026, 11:50 AM EDT
Recruiting Phase 2 Interventional

Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

NCT06608277
View directory record Official record
Conditions
Posttraumatic Headache, Posttraumatic Stress Disorder
Interventions
Group A active comparator, Group B active comparator, Group C Experimental, Group D Placebo Comparator
Procedure · Drug · Combination Product + 1 more
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Chicago, Illinois • Bethesda, Maryland • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

The Exercise and Concussion Health Study

NCT06494592
View directory record Official record
Conditions
Concussion, Mild, Concussion, Brain, TBI (Traumatic Brain Injury), TBI
Interventions
Aerobic Exercise, Balance Exercise
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
18 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study

NCT01042899
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
11 Years to 18 Years
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
5
States / cities
Denver, Colorado • Cincinnati, Ohio • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Sep 3, 2026, 11:50 AM EDT
Recruiting No phase listed Observational

Validating a Blood Test for the Detection of Traumatic Brain Injury in Children

NCT06940232
View directory record Official record
Conditions
Pediatric Traumatic Brain Injury
Interventions
Blood Test for Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acute Biomarkers
Diagnostic Test
Lead sponsor
University of Nebraska
Other
Eligibility
Up to 17 Years
Enrollment
330 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Not listed Not applicable Interventional

Strategy + RehaCom for Memory Rehabilitation in Traumatic Brain Injury (TBI)

NCT04239456
View directory record Official record
Conditions
Traumatic Brain Injury With Loss of Consciousness
Interventions
RehaCom (software)
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Sep 3, 2026, 11:50 AM EDT
Completed Not applicable Interventional

Telephone Intervention After Traumatic Brain Injury

NCT00483522
View directory record Official record
Conditions
Brain Injuries
Interventions
Self-management telephone counseling
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
16 Years and older
Enrollment
433 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
3
States / cities
Jackson, Mississippi • Philadelphia, Pennsylvania • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 19, 2012 · Synced Sep 3, 2026, 11:50 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treatment for Patients With Chronic Post-Concussion Symptoms

NCT03759808
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Concussion Post Syndrome
Interventions
Psychological Intervention
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 25 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 28, 2021 · Synced Sep 3, 2026, 11:50 AM EDT
Recruiting Not applicable Interventional

Mild TBI Assessment & Rehabilitation

NCT02920788
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Goal-Oriented Attentional Self-Regulation (GOALS), Brain Health Education (BHE), fMRI
Behavioral · Other · Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 3, 2026, 11:50 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The COACH Project: Combined Online Assistance for Caregiver Health

NCT03123224
View directory record Official record
Conditions
Traumas, Brain, Alzheimer Disease, Dementia, Head Injury, Concussion, Brain, TBI
Interventions
Combined Aerobic and Resistance Exercise + Caregiver Skills Training, Stretching Balance and Flexibility + Caregiver Skills Training
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Sep 3, 2026, 11:50 AM EDT
Active, not recruiting Not applicable Interventional

Hypertonic Saline for Mild TBI in Pediatric Patients

NCT07060105
View directory record Official record
Conditions
Head Injury, Minor, Pediatric, Emergency Department Patient
Interventions
Hypertonic Saline ( 3% Sodium Chloride Saline), Normal Saline (0.9% NaCl)
Other
Lead sponsor
University of Texas at Austin
Other
Eligibility
8 Years to 17 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 3, 2026, 11:50 AM EDT