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ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:31 PM EDT

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Showing 145–168 of 290 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: TKA Clear all
Withdrawn No phase listed Observational Accepts healthy volunteers

Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study

NCT02583113
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total and Unicompartment Knee Replacement
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2026
U.S. locations
1
States / cities
Leesburg, Florida
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Oct 19, 2026, 3:31 PM EDT
Active, not recruiting Not applicable Interventional

Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty

NCT04028947
View directory record Official record
Conditions
Knee Pain Chronic
Interventions
Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Withdrawn Not applicable Interventional

A Prospective Clinical Study Evaluating the Newton™ TKA Protocol

NCT06678750
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
TKA using computer navigation, TKA
Device · Procedure
Lead sponsor
Newton-Wellesley Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Newton, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional

Combined NMES and BFR Training After TKA

NCT04347343
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Standard Rehabilitation + Neuromuscular Electrical Stimulation and Blood Flow Restriction
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System

NCT03286543
View directory record Official record
Conditions
Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorder
Interventions
SPRINT Beta System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years to 90 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
La Jolla, California • Durham, North Carolina • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Results available

Comparison of 3 Techniques for Ultrasound-guided Femoral Nerve Catheter Insertion

NCT00927368
View directory record Official record
Conditions
Total Knee Replacement Surgery
Interventions
ultrasound guidance alone, ultrasound guidance and needle stimulation, ultrasound guidance and catheter stimulation
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
453 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Results available

Preventing Persistent Post-Surgical Pain and Dysfunction

NCT03965897
View directory record Official record
Conditions
Pain, Function, Anxiety, Depression, Arthroplasty, Replacement, Knee, Veterans
Interventions
Acceptance and Commitment Therapy (ACT), Attention Control (AC)
Behavioral · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
402 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Terminated Early Phase 1 Interventional

Multimodal Pain Management Following Primary TKA

NCT02369523
View directory record Official record
Conditions
Pain
Interventions
Exparel, Ropivacaine cocktail (PIC), Bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
40 Years to 90 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 15, 2023 · Synced Oct 19, 2026, 3:31 PM EDT
Terminated Phase 3 Interventional Results available

0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka

NCT03303794
View directory record Official record
Conditions
Anesthesia
Interventions
Exparel, 0.25% bupivacaine
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
40 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2020 · Synced Oct 19, 2026, 3:31 PM EDT
Recruiting Not applicable Interventional

Treatment Monitoring of Patients Receiving CDK 4/6 Inhibitors for Hormone Receptor (HR) Positive, HER2 Negative Metastatic Breast Cancer (MBC) With or Without the Addition of DiviTum® Serum Thymidine Kinase 1 (TK1) Activity Testing

NCT04968964
View directory record Official record
Conditions
Breast Cancer, Cancer of the Breast
Interventions
DiviTum® TKa assay, Study Care Plans
Device · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Results available

To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.

NCT04849884
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI™ KNEE TENSIONER
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
4
States / cities
New York, New York • New Albany, Ohio • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Completed No phase listed Observational

Is the STOP-BANG Predictive of Worsening OSA in the Early Postop Period in Patients Undergoing TJA?

NCT02123225
View directory record Official record
Conditions
Obstructive Sleep Apnea, Total Knee Arthroplasty
Interventions
Not listed
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 90 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2017 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Duloxetine RCT on Postop TKA Outcomes

NCT05086393
View directory record Official record
Conditions
Pain, Postoperative, Total Knee Arthroplasty
Interventions
Duloxetine, Placebos
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional

Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

NCT04910048
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions
POPOP (preoperative patient optimization program), SOC (standard of care)
Other
Lead sponsor
University of Arkansas
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 19, 2026, 3:31 PM EDT
Terminated Not applicable Interventional Results available

Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

NCT01084772
View directory record Official record
Conditions
Degenerative Arthritis of Knee
Interventions
VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
6
States / cities
Park Ridge, Illinois • Springfield, Illinois • St Louis, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reparel Knee Sleeve vs. TED Hose for Post-op Swelling, Pain and Range of Motion After Total Knee Replacement

NCT04751942
View directory record Official record
Conditions
Osteoarthritis Knees Both
Interventions
Non-compressive Bioactive Garment, thrombo-embolic deterrent
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beachwood, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 19, 2026, 3:31 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Suzetrigine in TKA

NCT07864896
View directory record Official record
Conditions
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery, Total Knee Replacements, Total Knee Replacement Arthroplasty, Suzetrigine, Pain Management, Pain, Nav 1.8, JOURNAVX, Opioid Cessation, Opioid Consumption, Postoperative, Multimodal Analgesia, Randomized Controlled Trial, Randomized Controlled Study, Randomized Controlled Trials
Interventions
Placebo, Suzetrigine
Other · Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional

Tka Assay for CDK4/6i

NCT06572800
View directory record Official record
Conditions
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic HER2-Negative Breast Carcinoma
Interventions
DiviTum-TKa
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
18
States / cities
Derby, Connecticut • Fairfield, Connecticut • Glastonbury, Connecticut + 13 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Oct 19, 2026, 3:31 PM EDT
Completed No phase listed Observational Results available

MAKO Total Knee Artroplasty

NCT05744895
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Device: Robotic MAKO total knee, FocusMotion knee brace, Fitbit tracking device, FocusMotion app
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Creve Coeur, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Active, not recruiting No phase listed Observational

Early Outcomes of MAKO Medial Unicompartmental Knee Arthroplasty

NCT05736601
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
focus motion knee brace
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
95 participants
Timeline
2022 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 13, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Terminated Phase 4 Interventional Results available

Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study

NCT00733330
View directory record Official record
Conditions
Osteoarthritis
Interventions
Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
Device
Lead sponsor
DePuy International
Industry
Eligibility
18 Years to 80 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Newport Beach, California • Winston-Salem, North Carolina • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 15, 2014 · Synced Oct 19, 2026, 3:31 PM EDT
Active, not recruiting Not applicable Interventional

Non-Surgical Management of Knee Osteoarthritis in the Military Health System (MHS)

NCT03747393
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
DoD/VA CPG Core Set + PT, DoD/VA CPG Core Set
Behavioral
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 60 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
3
States / cities
San Antonio, Texas • Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 19, 2026, 3:31 PM EDT
Completed Not applicable Interventional Results available

Adding Value in Knee Arthroplasty Post-total Knee Replacement (TKR) Care Navigator Trial

NCT01540851
View directory record Official record
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Care Navigator, Standard Post-Operative TKA Care
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
40 Years and older
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 9, 2018 · Synced Oct 19, 2026, 3:31 PM EDT