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ClinicalTrials.gov public records Last synced Sep 12, 2026, 11:57 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Targeted Temperature Management Clear all
Completed Phase 1Phase 2 Interventional Results available

Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO)

NCT01913340
View directory record Official record
Conditions
Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy, Birth Asphyxia
Interventions
Erythropoietin, Normal saline
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
30 Minutes to 24 Hours
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
7
States / cities
Little Rock, Arkansas • Palo Alto, California • San Francisco, California + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Phase 1 Interventional Results available

Reperfusion With Cooling in Cerebral Acute Ischemia

NCT01585597
View directory record Official record
Conditions
Stroke, Acute
Interventions
Zoll- Coolgaurd 3000
Device
Lead sponsor
Emory University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Phase 2 Interventional

Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

NCT01042015
View directory record Official record
Conditions
Cardiac Arrest From Trauma
Interventions
Emergency preservation and resuscitation, Standard resuscitation
Combination Product · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

NCT01765218
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Topiramate, Placebo
Drug
Lead sponsor
Kristin R Hoffman
Other
Eligibility
Up to 6 Hours
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2022
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2024 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RhinAer Procedure for Treatment of Chronic Rhinitis Study

NCT04533438
View directory record Official record
Conditions
Chronic Rhinitis
Interventions
RhinAer Stylus, Sham
Device
Lead sponsor
Aerin Medical
Industry
Eligibility
18 Years to 85 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
13
States / cities
Roseville, California • Torrance, California • Plantation, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Not applicable Interventional Results available

Study of a New Clinical Device for Reducing Body Core Temperature

NCT01996982
View directory record Official record
Conditions
Hypothermia
Interventions
CCS Device
Device
Lead sponsor
Seton Healthcare Family
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Not applicable Interventional

Therapeutic Hypothermia After the Return of Spontaneous Circulation

NCT01617291
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Induced therapeutic hypothermia
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2014 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Not applicable Interventional Results available

Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy

NCT03329131
View directory record Official record
Conditions
Peripheral Neuropathies
Interventions
Cryotherapy
Device
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Phase 4 Interventional

Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks

NCT00875862
View directory record Official record
Conditions
Adhesive Capsulitis, Post-operative Pain
Interventions
Interscalene catheter with Ropivicaine or normal saline
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Not applicable Interventional Results available

Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial

NCT00880087
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Therapeutic Hypothermia, Therapeutic Normothermia
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
48 Hours to 18 Years
Enrollment
329 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
25
States / cities
Birmingham, Alabama • Phoenix, Arizona • Loma Linda, California + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 12, 2026, 11:57 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

NCT06293638
View directory record Official record
Conditions
Essential Tremor
Interventions
Alcohol, Alprazolam, Cold Therapy, Peripheral Nerve Stimulation
Drug · Device · Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
30 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 12, 2026, 11:57 PM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Not applicable Interventional

REperfusion With Cooling in CerebraL Acute IscheMia II

NCT03804060
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Thermogard XP3, Recanalization only
Device · Procedure
Lead sponsor
ZOLL Circulation, Inc., USA
Industry
Eligibility
18 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
8
States / cities
Marietta, Georgia • Honolulu, Hawaii • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk

NCT03246243
View directory record Official record
Conditions
Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
Interventions
nfant feeding solution
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Up to 6 Months
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2021 · Synced Sep 12, 2026, 11:57 PM EDT
Terminated Phase 2 Interventional

Evaluation of Ultrafast Hypothermia Before Reperfusion in STEMI Patients

NCT01655433
View directory record Official record
Conditions
ST-elevation MI, Hypothermia
Interventions
Velomedix APLS device, No Hypothermia Treatment
Device · Other
Lead sponsor
Velomedix, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Huntsville, Alabama • Los Angeles, California • Gainesville, Georgia + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2014 · Synced Sep 12, 2026, 11:57 PM EDT
Completed No phase listed Observational

A Prospective Analysis of the Effect of Therapeutic Hypothermia After Cardiac Arrest

NCT00676598
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Not listed
Lead sponsor
Advocate Hospital System
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 5, 2012 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Massage for Post Breast Surgery

NCT02250898
View directory record Official record
Conditions
Postmastectomy Lymphedema Syndrome, Pain, Shoulder Mobility Impairment, Breast Surgery
Interventions
Myofascial Massage Therapy, Global Relaxation Massage
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
21 Years to 79 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Darbe Administration in Newborns Undergoing Cooling for Encephalopathy

NCT01471015
View directory record Official record
Conditions
Hypoxic Ischemic Encephalopathy
Interventions
Darbepoetin alfa, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
Up to 24 Hours
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
7
States / cities
Albuquerque, New Mexico • Nashville, Tennessee • Ogden, Utah + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Sep 12, 2026, 11:57 PM EDT
Withdrawn Phase 2 Interventional

Therapeutic Hypothermia for Severe Acute Pancreatitis

NCT01794858
View directory record Official record
Conditions
Pancreatitis
Interventions
Therapeutic Hypothermia
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2016 · Synced Sep 12, 2026, 11:57 PM EDT
Completed No phase listed Observational Results available

CoolCap Followup Study-Coordination of Participating Centers

NCT00581581
View directory record Official record
Conditions
Neonatal Encephalopathy
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
6 Years to 8 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Phase 3 Interventional

Acute Normovolemic Hemodilution Versus Standard Intraoperative Management in Patients Having Hepatic Resection and Pancreaticoduodenectomy

NCT00200148
View directory record Official record
Conditions
Pancreaticoduodenectomy, Hepatectomy
Interventions
Normovolemic Hemodilution (ANH), Standard of care
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Early Phase 1 Interventional

Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia

NCT02529202
View directory record Official record
Conditions
Hypoxic-ischemic Encephalopathy
Interventions
Dexmedetomidine
Drug
Lead sponsor
Seattle Children's Hospital
Other
Eligibility
1 Hour to 1 Day
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 12, 2026, 11:57 PM EDT
Completed No phase listed Observational

Neuroprognostication Using Optic Nerve Sheath Diameter

NCT03195881
View directory record Official record
Conditions
Heart Arrest, Intracranial Pressure Increase
Interventions
Ocular ultrasound
Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Sep 12, 2026, 11:57 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia

NCT01862250
View directory record Official record
Conditions
Encephalopathy, Hypoxic-Ischemic
Interventions
Clonidine (Duraclon®)
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
35 Weeks to 42 Weeks
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 4, 2018 · Synced Sep 12, 2026, 11:57 PM EDT