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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:31 AM EDT

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Showing 1–24 of 206 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Therapeutic Melatonin Clear all
Recruiting Not applicable Interventional

Affect of Melatonin on Sleep and Cognition in Cirrhosis

NCT07046429
View directory record Official record
Conditions
Hepatic Encephalopathy, Covert Hepatic Encephalopathy, Cirrhosis, Sleep Disturbances and Insomnia
Interventions
Melatonin tablet 3 mg once daily, Thiamine
Dietary Supplement
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep

NCT01586039
View directory record Official record
Conditions
Non-visual Photoreception
Interventions
Visible light
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 14, 2021 · Synced Oct 21, 2026, 12:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Melatonin Studies of Totally Blind Children

NCT00795236
View directory record Official record
Conditions
Sleep Disorder, Blindness
Interventions
Melatonin
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
5 Years to 20 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 27, 2019 · Synced Oct 21, 2026, 12:31 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Randomized Trial Investigating Melatonin Supplementation vs Placebo on Sleep Disturbance Following Total Joint Arthroplasty

NCT04590742
View directory record Official record
Conditions
Sleep Disturbance, Total Joint Arthroplasty
Interventions
melatonin 6mg, Placebo
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 99 Years
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 21, 2026, 12:31 AM EDT
Recruiting Not applicable Interventional

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

NCT07049783
View directory record Official record
Conditions
Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
Interventions
Exercise
Behavioral
Lead sponsor
Freda Patterson
Other
Eligibility
18 Years to 39 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Aug 17, 2025 · Synced Oct 21, 2026, 12:31 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women

NCT06617351
View directory record Official record
Conditions
Cell Migration, Cell Invasion, Exercise Recovery
Interventions
Melatonin, Placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 21, 2026, 12:31 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

NCT06104280
View directory record Official record
Conditions
Opioid Use Disorder, Sleep Disturbance
Interventions
Post-Illumination Pupillary Response (PIPR), Polysomnography, Multiple Sleep Latency Test, Ecological Momentary Assessments, Actigraphy, DLMO, Melatonin Suppression Test
Other · Behavioral · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 80 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

NCT00507546
View directory record Official record
Conditions
Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 21, 2026, 12:31 AM EDT
Not listed Not applicable Interventional

Sleep Quality and Pain Medication Use Following Arthroscopic Rotator Cuff Repair

NCT04278677
View directory record Official record
Conditions
Sleep Disturbance
Interventions
melatonin
Dietary Supplement
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Egg Harbor, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Phase 2 Interventional

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

NCT00097474
View directory record Official record
Conditions
Jet Lag
Interventions
Hydrocortisone, Melatonin, Placebo
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Light Sensitization Study

NCT01327040
View directory record Official record
Conditions
Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
Interventions
light exposure
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 30 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Oct 21, 2026, 12:31 AM EDT
Not listed Phase 4 Interventional

Effects of Ramelteon (8mg) Alone and in Combination With Multi-Component Behavioral Therapy on Sleep and Circadian Phase in Patients With Chronic Insomnia

NCT01180855
View directory record Official record
Conditions
Insomnia
Interventions
Placebo, Rozerem 8mg, Rozerem 8mg in combination with Multi Component Behavior Therapy
Drug · Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 12, 2010 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Individually Tailored Lighting System to Improve Sleep in Older Adults

NCT01855126
View directory record Official record
Conditions
Sleep Disturbances
Interventions
Blue light, Red light
Other
Lead sponsor
Rensselaer Polytechnic Institute
Other
Eligibility
65 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Troy, New York
Source: ClinicalTrials.gov public record
Updated Jan 29, 2019 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Somato® (Phytomelatonin) Versus Synthetic Melatonin and Placebo on Sleep Quality

NCT07669766
View directory record Official record
Conditions
Sleep
Interventions
Plant-based melatonin, Melatonin, Placebo
Dietary Supplement
Lead sponsor
Nutraland USA, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
244 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Phase 1 Interventional

Melatonin for Sleep in Children With Autism

NCT00927030
View directory record Official record
Conditions
Autistic Disorder, Insomnia
Interventions
supplemental liquid melatonin, flavored liquid or liquid supplemental melatonin
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
4 Years to 10 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 2, 2012 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Phase 3 Interventional Results available

Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients

NCT00513357
View directory record Official record
Conditions
Gastrointestinal Cancer, Lung Cancer
Interventions
Melatonin, Placebo
Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 11, 2012 · Synced Oct 21, 2026, 12:31 AM EDT
Terminated Early Phase 1 Interventional

Effects of Melatonin in Untreated Obstructive Sleep Apnea

NCT03492736
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Naomi Deacon
Other
Eligibility
30 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 31, 2019 · Synced Oct 21, 2026, 12:31 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift

NCT05701969
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 21, 2026, 12:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Neurobiological Effects of Light on MDD

NCT02940769
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
light glasses, sham glasses (placebo)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 21, 2026, 12:31 AM EDT
Terminated Not applicable Interventional Results available

Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome

NCT04105218
View directory record Official record
Conditions
Metabolic Syndrome, PreDiabetes, Hypertension, Obesity, Hyperlipidemias
Interventions
Exercise
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
19 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 21, 2026, 12:31 AM EDT
Terminated Not applicable Interventional

Does Melatonin Affect Anesthetic MAC (Minimum Alveolar Concentration)?

NCT03241004
View directory record Official record
Conditions
Anesthesia
Interventions
Sleep Mask
Other
Lead sponsor
Englewood Hospital and Medical Center
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Englewood, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 20, 2021 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Commercial "Sleep Lotion" on Salivary Melatonin Levels and Sleep Quality in Undergraduates

NCT06053385
View directory record Official record
Conditions
Sleep
Interventions
Melatonin sleep lotion, Placebo control lotion
Other
Lead sponsor
University of Redlands
Other
Eligibility
18 Years to 24 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Redlands, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional

Treatment for Sleep Disturbance in Orthopaedic Trauma Patients

NCT03779243
View directory record Official record
Conditions
Sleep Disturbance, Trauma
Interventions
Melatonin 5mg and Sleep Education, Placebo
Dietary Supplement · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Dec 3, 2021 · Synced Oct 21, 2026, 12:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Color-dependent Melatonin Suppression

NCT02936674
View directory record Official record
Conditions
Melatonin
Interventions
Light - standard, Light - alternate
Device
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years to 35 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 5, 2018 · Synced Oct 21, 2026, 12:31 AM EDT