Independent directory Public ClinicalTrials.gov records United States
Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 9, 2026, 11:51 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 169–192 of 206 matching trials from the live ClinicalTrials.gov search.
Conditions
Seasonal Affective Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Completed Not applicable Interventional Accepts healthy volunteers

The Effectiveness of a Proprietary of a Botanical Extract on Sleep Quality

NCT06894108
Conditions
Sleep
Interventions
Proprietary Blend of Botanical Extracts, Melatonin
Dietary Supplement
Lead sponsor
Nutraceuticals Research Institute
Other
Eligibility
35 Years to 55 Years · Female only
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Huntsville, Alabama
Conditions
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Sleep Disturbance
Interventions
Melatonin, Bedtime Bank
Dietary Supplement · Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
10 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Omaha, Nebraska
Conditions
Type 1 Diabetes (T1D), Sleep Health
Interventions
Sleep Health and Circadian Timing Intervention
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
14 Years to 19 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Conditions
Alzheimer's Disease, Sleep Disorder
Interventions
Circadin, Placebo
Drug
Lead sponsor
Neurim Pharmaceuticals Ltd.
Industry
Eligibility
50 Years to 85 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
4
States / cities
Brooksville, Florida • St. Petersburg, Florida • Mount Arlington, New Jersey + 1 more
Conditions
Sleep, Sleep Disturbance, Sleep Hygiene
Interventions
Beam Organics Dream Powder, Beam Organics Dream Powder Extra Strength, Placebo
Dietary Supplement
Lead sponsor
Beam
Industry
Eligibility
24 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Santa Monica, California
Conditions
Sleep Disturbance, Trauma
Interventions
Melatonin 5mg and Sleep Education, Placebo
Dietary Supplement · Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Stanford, California
Conditions
Unipolar Depression
Interventions
Triple Therapy
Other
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
New York, New York
Conditions
Delirium
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Scripps Health
Other
Eligibility
65 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
La Jolla, California
Conditions
Long COVID, Long COVID-19, Sleep Disturbance
Interventions
Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo
Drug · Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
469 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Non-visual Photoreception
Interventions
Visible light
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Completed Early Phase 1 Interventional Results available

Melatonin in Patients With Multiple Sclerosis (MS).

NCT03498131
Conditions
Relapsing Remitting Multiple Sclerosis
Interventions
3 mg Melatonin, 5 mg Melatonin
Drug
Lead sponsor
Providence Health & Services
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Completed Phase 1 Interventional Accepts healthy volunteers

Melatonin-Micronutrients for Osteopenia Treatment Study

NCT01870115
Conditions
Osteoporosis, Osteopenia
Interventions
Fiber Pill, Melatonin, Strontium citrate, Vitamins D3 and K2
Dietary Supplement
Lead sponsor
Duquesne University
Other
Eligibility
Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Methylxanthine, Light Therapy
Drug · Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boulder, Colorado
Conditions
Attention Deficit Hyperactivity Disorder
Interventions
Sleep Intervention, Melatonin
Behavioral · Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Years to 12 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Not listed Not applicable Interventional Accepts healthy volunteers

Uterine Contractions Under Blue Light

NCT03691740
Conditions
Preterm Contractions
Interventions
Ocular light
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Completed No phase listed Observational Accepts healthy volunteers

A Study of Melatonin Concentration During Lactation

NCT06393296
Conditions
Breastfeeding
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Eau Claire, Wisconsin
Conditions
Rapid Eye Movement Sleep Behavior Disorder, Parkinson Disease
Interventions
Immediate Release Melatonin, Extended Release Melatonin
Dietary Supplement
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Jacksonville, Florida
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence

NCT01014533
Conditions
Alcohol Dependence, Insomnia
Interventions
Placebo dispensed to subject., Gabapentin dispensed to subject.
Drug
Lead sponsor
Dr. Kirk Brower
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Ann Arbor, Michigan
Conditions
Psychosis, Sleep
Interventions
oral melatonin tablets (NatureMade brand), Placebo
Drug · Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 30 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Sleep
Interventions
Sleep friendly order set, Patient sleep menu
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Terminated Not applicable Interventional Results available

Young Blind Child Melatonin Treatment Study

NCT00688935
Conditions
Blindness
Interventions
Melatonin
Biological
Lead sponsor
Oregon Health and Science University
Other
Eligibility
1 Year to 20 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Completed Phase 2 Interventional Results available

Melatonin and the Metabolic Syndrome

NCT01038921
Conditions
Metabolic Syndrome
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
30 Years to 79 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Atlanta, Georgia
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of Sleep Extension in Adolescents

NCT03500458
Conditions
Insulin Sensitivity, Sleep, Dietary Habits
Interventions
Sleep Extension
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
14 Years to 19 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
1
States / cities
Aurora, Colorado