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ClinicalTrials.gov public records Last synced Oct 24, 2026, 2:40 AM EDT

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Showing 577–600 of 1,613 matching trials from the live ClinicalTrials.gov search.
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Terminated Phase 2 Interventional Results available

Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer

NCT00751101
View directory record Official record
Conditions
Breast Cancer, Chemotherapeutic Agent Toxicity, Palmar-plantar Erythrodysesthesia
Interventions
Nicotine patch
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Oct 24, 2026, 2:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Adverse Airway Effects From Tobacco and E-Cigarettes

NCT03251053
View directory record Official record
Conditions
Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco, Smoking, Cigarette
Interventions
Electronic cigarette use, Control regular cigarette smokers
Device · Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia

NCT00770237
View directory record Official record
Conditions
Schizophrenia, Nicotine Dependence
Interventions
Smoking Cues, Neutral Cues
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 64 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Health Literacy and Obesogenic Behaviors

NCT04252677
View directory record Official record
Conditions
Obesity, Adolescent, Health Behavior, Health Knowledge, Attitudes, Practice, Diet, Healthy, Exercise, Health Literacy
Interventions
Obesity Prevention, Health Literacy
Behavioral
Lead sponsor
City University of New York, School of Public Health
Other
Eligibility
13 Years to 17 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers

NCT03543137
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
19 Years to 55 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 4, 2019 · Synced Oct 24, 2026, 2:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Communicating About Nicotine Reduction in Cigarettes

NCT06787937
View directory record Official record
Conditions
Tobacco Products, Smoking Behavior, Cigarette Use
Interventions
VLNC messages, Control message
Behavioral
Lead sponsor
Georgia State University
Other
Eligibility
21 Years and older
Enrollment
1,230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Smoking Tobacco and Drinking Study

NCT03163303
View directory record Official record
Conditions
Smoking, Heavy Episodic Drinking
Interventions
Tobacco Status Project Intervention, Tobacco Status Project + Alcohol Intervention, nicotine patch
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Extended Cessation Treatment for Teen Smokers

NCT00459953
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Extended treatment
Drug
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2011
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 30, 2016 · Synced Oct 24, 2026, 2:40 AM EDT
Withdrawn Not applicable Interventional

Development of a Scalable Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness

NCT04340102
View directory record Official record
Conditions
Tobacco Cessation
Interventions
BecomeAnEx
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 6, 2020 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations

NCT03822546
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Conventional cigarette, myblu 25 mg freebase, myblu 16 mg nicotine salt, myblu 25 mg nicotine salt, myblu 40 mg nicotine salt, blu PRO 48 mg nicotine salt
Other
Lead sponsor
Fontem Ventures BV
Industry
Eligibility
25 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jan 30, 2019 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of an Oral Nicotine Product in Smokeless Tobacco Users

NCT05280769
View directory record Official record
Conditions
Tobacco Use
Interventions
oral nicotine pouch - 2 mg, oral nicotine pouch - 4 mg, oral nicotine pouch - 8 mg, Smokeless tobacco
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional

Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center

NCT03060278
View directory record Official record
Conditions
Smoking Cessation
Interventions
Self-help materials, nicotine patch, Smartphone-delivered automated treatment, Counseling
Behavioral · Drug · Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs

NCT01589068
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Intravenous Nicotine, Progesterone
Drug
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 40 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2015
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smartphone-based Financial Incentives

NCT03922360
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Smartphone-based Financial Incentives, Best Practices
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 2 Interventional Results available

A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications

NCT01576718
View directory record Official record
Conditions
Asthma
Interventions
Fp MDPI, Placebo MDPI, Flovent Diskus, albuterol/salbutamol
Drug · Other
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
12 Years and older
Enrollment
889 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
148
States / cities
Birmingham, Alabama • Homewood, Alabama • Goodyear, Arizona + 114 more
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Feasibility, Acceptability, Usability, and an Initial Estimate of Effect of a Novel Training Platform on Peer Recovery Supporter Skill, Adherence, and Knowledge Gain-Phase I

NCT07090590
View directory record Official record
Conditions
Substance-related Disorders, Alcohol and Other Substance Use Prevention, Alcohol and Other Drug Use Disorders
Interventions
Thrive Digital Peer Platform (TDPP)
Behavioral
Lead sponsor
Thrive Digital Health, LLC
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Solon, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 1Phase 2 Interventional

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

NCT00593099
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Bupropion, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional

Nicotine Replacement Therapy Prescribing and Lung Cancer Screening in Hospitalized Patients

NCT07164404
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
EHR alert
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional Results available

Methadone-Maintained Smokers Switching to E-Cigarettes

NCT05206435
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use
Interventions
Electronic Cigarette, Nicotine Lozenge
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
183 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 24, 2026, 2:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Onsite Tobacco Cessation Treatment for Patients With PAD

NCT05469698
View directory record Official record
Conditions
Tobacco Cessation, Peripheral Artery Disease
Interventions
Tobacco Treatment Research Program Standard Care
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Oct 24, 2026, 2:40 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI

NCT01036711
View directory record Official record
Conditions
Nicotine Dependence, Drug Abuse
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
249 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Advancing Tobacco Use Treatment for African American Smokers

NCT02360631
View directory record Official record
Conditions
Smoking Cessation
Interventions
Chantix, Placebo
Drug
Lead sponsor
Lisa Sanderson Cox, PhD
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Kansas City, Kansas • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Phase 4 Interventional Results available

Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers

NCT01048944
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Bupropion SR, Nicotine Patch, Placebo Patch and Placebo Pill
Drug
Lead sponsor
Southern Illinois University Carbondale
Other
Eligibility
18 Years to 55 Years
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
Carbondale, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 25, 2014 · Synced Oct 24, 2026, 2:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Evaluate Nicotine Uptake and Biomarkers in Smokers Using mybluTM Electronic Cigarettes

NCT04430634
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Myblu variant A, Myblu variant B, Myblu variant C, Myblu variant D, Myblu variant E, Myblu variant F, Myblu variant G, Myblu variant H
Other
Lead sponsor
Fontem US LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 7, 2021 · Synced Oct 24, 2026, 2:40 AM EDT