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Showing 169–192 of 1,613 matching trials from the live ClinicalTrials.gov search.
Conditions
Tobacco Use
Interventions
3 mg/mL nicotine strength e-liquid, 6 mg/mL nicotine strength e-liquid, 12 mg/mL nicotine strength e-liquid, 24 mg/mL nicotine strength e-liquid
Drug
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Roanoke, Virginia
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smokers' Response to Nicotine Dependence Genotyping

NCT01780038
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Receipt of Genetic Results, No results given
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Conditions
Post Traumatic Stress Disorder, Problem Drinking
Interventions
App-based intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Seattle, Washington
Completed Phase 4 Interventional Results available

A Text Messaging Program for Smokers in Primary Care

NCT03174158
Conditions
Smoking Cessation
Interventions
Mailed nicotine replacement therapy, Text messaging, Brief advice
Drug · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Active, not recruiting Phase 2 Interventional Accepts healthy volunteers

Mobile App for Smoking Cessation and Mental Health

NCT04887558
Conditions
Smoking Cessation, Mental Illness
Interventions
Smart-T Mental Health+ and NRT, QuitGuide + NRT
Combination Product
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 100 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Completed Not applicable Interventional Results available

Learn to Quit-HIV Pilot Study

NCT04609514
Conditions
HIV/AIDS, Smoking Cessation, Tobacco Use Disorder
Interventions
Learn to Quit-HIV, QuitGuide, Nicotine patch, Smartphone coaching
Device · Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Smoking Cessation
Interventions
Distress Tolerance Treatment for Weight Concern (DT-W), Health Education (HE)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Conditions
Cigarette Smoking, Drug Use
Interventions
Standard Treatment, BAD-AS, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Conditions
Tobacco Use Disorder
Interventions
Memantine
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
New York, New York
Conditions
Depressive Disorder
Interventions
Transdermal Nicotine Patch, Transdermal Placebo Patch
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Conditions
Alcoholism, Smoking
Interventions
nicotine replacement patch
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2002
U.S. locations
1
States / cities
West Haven, Connecticut
Conditions
Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
Interventions
Motivation-Phase Varenicline, Motivation-Phase Nicotine Mini-Lozenge, Cessation-Phase Combination Nicotine Replacement Therapy (NRT), Cessation-Phase Varenicline, Motivation-Phase Counseling, Cessation-Phase Counseling
Drug · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
San Diego, California • Minneapolis, Minnesota • Durham, North Carolina + 1 more
Conditions
Tobacco Dependence
Interventions
C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker, Lung Cancer Screening
Behavioral · Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Results available

A Quit Smoking Study Using Smartphones

NCT02164383
Conditions
Smoking Cessation, Smoking, Nicotine Dependence
Interventions
Nicotine patch, Cessation Counseling, Mobile Games
Drug · Behavioral · Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Madison, Wisconsin
Completed Not applicable Interventional Accepts healthy volunteers

CSD201002: Study to Assess Nicotine Uptake From P10 Nicotine Pouches

NCT05081154
Conditions
Smoking, Tobacco Use
Interventions
Product A, Product B, Product C, Product D, Product E, Product F, Product G
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Knoxville, Tennessee
Conditions
Nicotine Dependence
Interventions
Zyban
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years to 60 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2011
U.S. locations
1
States / cities
West Los Angeles, California
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study

NCT02783768
Conditions
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Interventions
E-cigarette, Sham, Hyperpolarized 3-Helium, Gadolinium
Device · Other · Drug
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Results available

Quit or Switch: E-cigarette Study

NCT05525078
Conditions
Tobacco Use
Interventions
e-cigarette, Nicotine patch, Nicotine lozenge
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes Plus Electronic Cigarettes

NCT04058717
Conditions
Tobacco Dependence
Interventions
Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Conditions
Nicotine Dependence
Interventions
low dose Nicotine, high dose Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Haven, Connecticut
Conditions
Tobacco Use, Cigarette Use
Interventions
Emotion-based messages about the harm of VLNC, Continued-harm-framed messages about the harm of VLNC, Myth-refuting messages about the harm of VLNC, Control messages about littering
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Tobacco Flavoring and Liquid Composition on Vaping Topography

NCT05876091
Conditions
Tobacco-Related Carcinoma
Interventions
Vaping, Biospecimen Collection, Questionnaire Administration
Other · Procedure
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Conditions
Suicide
Interventions
Toward Hope, Recovery, Interpersonal Growth, Values, and Engagement (THRIVE), Center Care as Usual
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
552 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
3
States / cities
Huntsville, Alabama • Phoenix, Arizona • Nashville, Tennessee