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ClinicalTrials.gov public records Last synced Nov 11, 2026, 11:14 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 42 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Tissue sealant Clear all

Conditions: Parenchymous Tissue Surgical Bleeding
Interventions: Fibrin Sealant Grifols, Surgicel®; Biological · Device
Lead sponsor: Instituto Grifols, S.A.; Industry
Eligibility: Not listed
Enrollment: 325 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 26
States / cities: Loma Linda, California • Los Angeles, California • New Haven, Connecticut + 21 more

Conditions: Peripheral Vascular Disease
Interventions: Gelfoam/Thrombin, VascuSeal; Device
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: Epithelial Ingrowth
Interventions: Tissue sealant; Drug
Lead sponsor: Stanford University; Other
Eligibility: 21 Years to 99 Years
Enrollment: 2 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Osteoarthritis
Interventions: Evicel fibrin sealant; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 20 Years to 90 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: New York, New York

Conditions: Compare Ecchymosis and Edema for Fibrin Sealant and no Fibrin Sealant
Interventions: Fibrin Sealant (Artiss); Drug
Lead sponsor: Nguyen, Davis B., M.D.; Individual
Eligibility: 18 Years to 75 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Beverly Hills, California

Conditions: Pain, Postoperative, Root Canal Infection, Endodontically Treated Teeth
Interventions: GentleWave, Conventional Protocol; Other
Lead sponsor: University of Salamanca; Other
Eligibility: 18 Years to 80 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Manhattan, New York

Conditions: Facial Rhytidectomy (Face-lift)
Interventions: Fibrin Sealant with 4 IU/ml Thrombin, Vapor-Heated, Solvent Detergent Treated Containing Synthetic Aprotinin (FS VH S/D 4); Biological
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 6
States / cities: Beverly Hills, California • Los Angeles, California • Atlanta, Georgia + 3 more

Conditions: Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
Interventions: BIOSTAT BIOLOGX, Saline; Biological · Drug
Lead sponsor: Spinal Restoration, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 20
States / cities: Birmingham, Alabama • Phoenix, Arizona • Chula Vista, California + 17 more

Conditions: Mild or Moderate Surgical Bleeding
Interventions: Fibrocaps, Gelatin sponge; Biological
Lead sponsor: Mallinckrodt; Industry
Eligibility: 18 Years and older
Enrollment: 721 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 29
States / cities: Birmingham, Alabama • Los Angeles, California • Orange, California + 24 more

Conditions: Breast Cancer, Perioperative/Postoperative Complications
Interventions: fibrin sealant (Beriplast P, TISSEEL VH), breast reconstruction; Drug · Procedure
Lead sponsor: OHSU Knight Cancer Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Cerebrospinal Fluid Leak
Interventions: EVICEL Fibrin Sealant, Hydrogel sealant; Biological · Device
Lead sponsor: Ethicon, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 13
States / cities: Los Angeles, California • Sacramento, California • Jacksonville, Florida + 10 more

Conditions: Elective Cranial Procedures With Dural Incision
Interventions: DuraSeal Dural Sealant System, Standard of Care; Device · Other
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 237 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy, Annular Disc Tear
Interventions: Fibrin sealant; Drug
Lead sponsor: Pauza, Kevin, MD; Other
Eligibility: 18 Years to 80 Years
Enrollment: 400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Tyler, Texas

Conditions: Hemorrhage, Soft Tissue Bleeding
Interventions: EVARREST™ Fibrin Sealant Patch, Standard of Care; Biological · Other
Lead sponsor: Ethicon, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Pathological Processes in the Posterior Fossa, Dura Defects
Interventions: Fibrin Sealant, Vapor Heated, Solvent/Detergent-treated with 500 IU/mL thrombin and synthetic aprotinin (FS VH S/D 500 s-apr), Standard of care; Biological · Procedure
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 3 Years and older
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 12
States / cities: Duarte, California • Sacramento, California • San Diego, California + 9 more

Conditions: Benign Renal Tumors, Malignant Renal Tumors
Interventions: Laser Tissue Welding Device; Device
Lead sponsor: Laser Tissue Welding, Inc.; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Lymphedema, Perioperative/Postoperative Complications, Vulvar Cancer
Interventions: fibrin sealant, surgical wound closure; Drug · Procedure
Lead sponsor: Gynecologic Oncology Group; Network
Eligibility: 18 Years and older · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2003
U.S. locations: 49
States / cities: Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 45 more

Conditions: Open Thoracotomy
Interventions: PleuraSeal Sealant System, Standard Tissue Closure Techniques; Device · Procedure
Lead sponsor: Integra LifeSciences Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 230 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Bedford, Massachusetts

Conditions: Burns
Interventions: Sheet skin grafts affixed with Fibrin Sealant (lyophilized) with 4 IU/mL Thrombin; Drug
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 6 Years to 65 Years
Enrollment: 40 participants
Timeline: 2002 – 2004
U.S. locations: 12
States / cities: Mobile, Alabama • Phoenix, Arizona • Orange, California + 9 more

Conditions: Recovery Time, Bruising
Interventions: Fibrinogen, Septorhinoplasty, Taping after septorhinoplasty., Cast applied to the nose after nasal surgery, Saline; Drug · Procedure · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Cardiovascular Disease
Interventions: EVARREST™, Topical hemostat, Standard of Care; Biological · Other
Lead sponsor: Ethicon, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 6
States / cities: Indianapolis, Indiana • Kansas City, Missouri • Camden, New Jersey + 2 more

Conditions: Diabetic Foot Ulcer
Interventions: PEP (Purified Exosome Product) / TISSEEL; Biological
Lead sponsor: Rion Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 59 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Blue Ash, Ohio

Conditions: Pressure Ulcer
Interventions: Adipose-derived stromal cells, Adipose-derived stromal cells; Biological · Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Cerebrospinal Fluid Leak
Interventions: FS VH S/D 500 s-apr, DuraSeal Dural Sealant; Drug · Device
Lead sponsor: Baxter Healthcare Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 10
States / cities: Springfield, Illinois • Springfield, Massachusetts • Detroit, Michigan + 7 more

Search by objective public record fields.

Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries

Study to Evaluate Safety & Effectiveness of Vascular Sealant System

Tissue Sealant Use in LASIK Enhancement Surgery

The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift

Effectiveness of GentleWave System in Endodontic Treatment

Efficacy and Safety Study of Fibrin Sealant With 4 IU/mL Thrombin, Vapor Heated, Solvent Detergent Treated (FS VH S/D 4) in Face-Lift Procedures

Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System

A Study of Fibrocaps™ in Surgical Bleeding

Fibrin Sealant in Preventing Fluid Build Up During Surgery in Patients Undergoing Breast Reconstruction

The EVICEL® Neurosurgery Phase III Study

DuraSeal Sealant Post Market Study

Fibrin for Chronic Multi-level Discogenic Low Back Pain

EVARREST™ Fibrin Sealant Patch Post-Market Study

Fibrin Sealant for the Sealing of Dura Sutures

First-in-Human Safety Study Of Laser Tissue Welding For Surtureless Laparoscopic Partial Nephrectomy

Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva

PleuraSeal Pivotal Study (US)

Safety and Efficacy Study of Fibrin Sealant (FS 4IU) for Skin Graft Fixation and Wound Healing in Subjects With Burn Wounds

Study Evaluating Benefit of Using Fibrin Glue in Septorhinoplasty

The Fibrin Pad Cardiovascular Study

Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)

Adipose-Derived Stromal Cells (ASC's) for Pressure Ulcers

Efficacy and Safety of FS VH S/D 500 S-apr (Tisseel) as an Adjunct to Sutured Dural Repair in Cranial Surgery