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ClinicalTrials.gov public records Last synced Oct 11, 2026, 6:52 PM EDT

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Showing 217–240 of 872 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Tobacco Cessation Clear all
Recruiting Phase 2 Interventional

The Potential of Kava in Enabling Tobacco Cessation - Its Holistic Effects in Managing Stress and Insomnia Associated With Abstinence

NCT05814055
View directory record Official record
Conditions
Smoking
Interventions
Placebo, AB-free kava
Drug
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 75 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Mi QUIT CARE (Mile Square QUIT Community-Access-Referral-Expansion)

NCT04827420
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Mi Quit Care
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Tobacco Cessation at FDNY

NCT05997225
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Use Cessation
Interventions
opt out enrollment, tailored counseling, varenicline started prior to target quit date, opt in enrollment, non-tailored counseling, varenicline started prior to target quit date
Other
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
40 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Recruiting Phase 4 Interventional

Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care

NCT06598397
View directory record Official record
Conditions
Human Immunodeficiency Virus (HIV), Smoking Cessation
Interventions
Motivational Interviewing (MI) Counseling, Peer Mentoring, Skills-based Text Messaging, Combination NRT
Behavioral · Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Results available

Tobacco Cessation for Veterans With Post Traumatic Stress Disorder (PTSD)

NCT00908882
View directory record Official record
Conditions
Tobacco Use Cessation, Post Traumatic Stress Disorders
Interventions
Motivation Interviewing Counseling
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 16, 2015 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of Smoking Environments on Brain Reactivity

NCT03421210
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine patch
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 19, 2021 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 2 Interventional Results available

Targeted Interventions for Weight-Concerned Smokers

NCT00105482
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Naltrexone, Transdermal nicotine replacement, Behavioral counseling
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV

NCT01886924
View directory record Official record
Conditions
Smoking Cessation
Interventions
Brief Computer MI for Smoking Cessation, Nutrition Control
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 20, 2016 · Synced Oct 11, 2026, 6:52 PM EDT
Active, not recruiting Not applicable Interventional Results available

Automated Video-Assisted Smoking Treatment for People Living With HIV

NCT05014282
View directory record Official record
Conditions
Smoking Cessation
Interventions
Nicotine patch, Counseling, Nicotine lozenge, Smartphone-delivered automated treatment
Drug · Behavioral
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 3 Interventional Results available

Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction

NCT00392379
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
Nicotine Lozenges, Placebo lozenge
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Rochester, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 24, 2013 · Synced Oct 11, 2026, 6:52 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

A Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers

NCT05044546
View directory record Official record
Conditions
Depression, Tobacco Use Disorder
Interventions
Behavioral Activation Therapy, Discussion, Health Education, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Procedure · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 2 Interventional

Depressed Mood Improvement Through Nicotine Dosing 3

NCT05746273
View directory record Official record
Conditions
Depressive Disorder
Interventions
Transdermal Nicotine Patch, Transdermal Placebo Patch
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers (AMERIDIAN)

NCT00387946
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation
Interventions
SSR591813L (dianicline)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2012 · Synced Oct 11, 2026, 6:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tobacco Cessation for Sexual Minorities

NCT03643679
View directory record Official record
Conditions
Smoking Cessation
Interventions
Kwit smartphone app
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 30 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Results available

Tobacco Intervention in Primary Care Treatment Opportunities for Providers

NCT02096029
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Ask, Advise, Refer (physician brief advice)
Other · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
1,278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Oct 11, 2026, 6:52 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Delivery Systems: Research & Treatment

NCT00108342
View directory record Official record
Conditions
Smoking
Interventions
Nicotine gum - 2 mg and 4 mg, Nicotine lozenges - 2 mg and 4 mg, Nicotine inhaler (4 mg yield) - low and high "dosage" by frequency of puffing, Computer learning
Drug · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
21 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 4, 2014 · Synced Oct 11, 2026, 6:52 PM EDT
Terminated Phase 4 Interventional

Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-breastfeeding Women

NCT00119210
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion SR, placebo
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 29, 2011 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 2 Interventional Results available

Free Samples for Health

NCT05627596
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Ask-Advise-Refer, Nicotine Patch, 14 Mg/24 Hr Transdermal Film, Extended Release, Nicotine lozenge
Behavioral · Drug
Lead sponsor
Sandra Japuntich
Other
Eligibility
18 Years and older
Enrollment
1,239 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Results available

WeChat Quit Coach Pilot Study

NCT05130788
View directory record Official record
Conditions
Smoking Cessation
Interventions
WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges
Behavioral · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Exenatide Once Weekly for Smoking Cessation

NCT02975297
View directory record Official record
Conditions
Smoking Cessation
Interventions
Exenatide, NRT, Counseling, Placebo
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2021 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Innovative Web-Based Intervention for Smoking Cessation Among College Students

NCT01982825
View directory record Official record
Conditions
Tobacco Use Cessation, Cigarette Smoking
Interventions
Online intervention arm, Online control arm
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 30 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 5, 2013 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Results available

Integrating Tobacco Treatment Into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial

NCT01871506
View directory record Official record
Conditions
Smoking Cessation
Interventions
Standard Care (SC), Intensive Counseling (IC)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
303 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
3
States / cities
Boston, Massachusetts • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Early Phase 1 Interventional

Non Invasive Oral Cancer Screening Among HIV Infected Individuals

NCT02823847
View directory record Official record
Conditions
Malignant Neoplasms of Mesothelial and Soft Tissue, Human Immunodeficiency Virus
Interventions
Screening Interview, Carbon Monoxide Test, Self-Help Materials, Visual Oral Screening Examination, Direct Fluorescent Oral Visualization Examination, Oral Biopsy
Behavioral · Device · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Oct 11, 2026, 6:52 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Text-based Reduction Intervention for Smokeless Tobacco Cessation- Pilot Study

NCT06637358
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
Extended Scheduled Gradual Reduction (SGR), Quit Coach
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 11, 2026, 6:52 PM EDT