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ClinicalTrials.gov public records Last synced Oct 7, 2026, 7:29 AM EDT

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Showing 49–72 of 140 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Tobacco Flavors Clear all
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

NCT05110872
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 7, 2026, 7:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

NCT06763536
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Carbon Monoxide Measurement, Nicotine Lozenge, Oral Nicotine Pouch, Nicotine Patch, Survey Administration, Check-in Phone Calls
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco

NCT01509586
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
19 Years and older
Enrollment
1,236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2023 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing Legally Feasible Options: Study 1

NCT04259749
View directory record Official record
Conditions
Tobacco Use
Interventions
Flavor Ban, Menthol Ban, All flavored and mentholated products available
Other
Lead sponsor
RAND
Other
Eligibility
11 Years to 20 Years
Enrollment
267 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

NCT02323438
View directory record Official record
Conditions
Smoking
Interventions
Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 7, 2026, 7:29 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

NCT05896033
View directory record Official record
Conditions
Smoking Prevention and Control
Interventions
Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Results available

Patch Study - Intervention for HIV Positive Smokers

NCT02982772
View directory record Official record
Conditions
Smoking Cessation, HIV
Interventions
Combination Therapy, Standard Care Intervention
Other
Lead sponsor
dr. maria miguez
Other
Eligibility
18 Years and older
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarettes on Nicotine Concentrations

NCT01775787
View directory record Official record
Conditions
Health Behavior
Interventions
Nicotine with Tobacco Flavor and Tobacco & Menthol Flavor
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 55 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 30, 2017 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Responses of Adults Smoking Nondaily and Daily in the Experimental Tobacco Marketplace

NCT06988371
View directory record Official record
Conditions
Tobacco Use, Cigarette Use
Interventions
Reduced nicotine regulatory environment, Restriction on characterizing flavors in combustible nicotine products, Restriction on characterizing flavors in noncombustible nicotine products
Behavioral
Lead sponsor
Bethany Shorey Fennell, PhD
Other
Eligibility
18 Years and older
Enrollment
747 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Phase 1Phase 2 Interventional

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

NCT02590393
View directory record Official record
Conditions
Nicotine Dependence
Interventions
E-cigarettes
Combination Product
Lead sponsor
Duke University
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Phase 1 Interventional Results available

Effects of E-Cigarette Flavors on Adults TCORS 2.0

NCT03635333
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Nicotine, Flavor
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 50 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes

NCT04188197
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking, Tobacco Dependence, Tobacco Use Cessation
Interventions
JUUL
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD231005 Nicotine Pouch Biomarkers of Exposure

NCT06303115
View directory record Official record
Conditions
Tobacco Use, Smoking
Interventions
Nicotine Pouch P1312914, 4 mg nicotine, Nicotine Pouch P1312915, 8 mg nicotine, Nicotine Pouch P1013215, 8 mg nicotine, Nicotine Pouch P1013218, 10 mg nicotine, Nicotine Pouch P1012919, 12 mg nicotine, Smoking Abstinence, Continued UB cigarette smoking
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
5
States / cities
Bentonville, Arkansas • Lexington, Kentucky • Springfield, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2025 · Synced Oct 7, 2026, 7:29 AM EDT
Active, not recruiting Early Phase 1 Interventional

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

NCT05239793
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
NJOY e-cigarette
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 74 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

NCT02179034
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product
Interventions
Nicotine, Low Dose Menthol, High Dose Menthol
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 4, 2020 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use

NCT03402243
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)

NCT05320887
View directory record Official record
Conditions
Tobacco Use
Interventions
Normal Nicotine Content Vape with all flavor e-liquids, Normal nicotine content vape with tobacco e-liquids, Low nicotine content vape with all flavor e-liquids, Low nicotine content vape with tobacco e-liquids
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Delivery From Novel Non-Tobacco Electronic System in Smokers

NCT02575885
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Healthy Subject
Interventions
Electronic Cigarette, Laboratory Biomarker Analysis, Pharmacological Study, Questionnaire Administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jun 12, 2018 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Characterize the Nicotine Uptake and Subjective Effects With Use of JUUL Electronic Nicotine Delivery Systems

NCT04123041
View directory record Official record
Conditions
Electronic Cigarette Use, Tobacco Smoking
Interventions
JUUL ENDS, Combustible cigarette, comparator e-cigarette, Nicorette gum
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
2
States / cities
Kansas City, Kansas • Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Feb 13, 2020 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Effects of Menthol in E-cigarettes on Smoking Behaviors

NCT04521647
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding the Effect of Flavor on Hookah Smoking Experience

NCT03589599
View directory record Official record
Conditions
Waterpipe Smoking
Interventions
Flavored tobacco, Non-flavored tobacco
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 30 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 3, 2020 · Synced Oct 7, 2026, 7:29 AM EDT
Completed Not applicable Interventional

C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)

NCT04358705
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey, Online Experimental Marketplace (ETM), Aim 3 survey, Cognitive Interviews, Supplemental Aim 1 Interviews
Other · Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
16 Years to 28 Years
Enrollment
658 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Oct 7, 2026, 7:29 AM EDT