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Showing 1–24 of 2,313 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Tobacco Smoking Clear all
Not listed Phase 3 Interventional Accepts healthy volunteers

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

NCT01892813
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use
Interventions
Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge, Bupropion, Varenicline, Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Tobacco quitline referral, Tailored behavioral intervention, Alcohol use risk reduction, Behavioral activation for depressive symptoms, Behavioral management of postcessation weight gain
Drug · Behavioral
Lead sponsor
Mark Vander Weg
Other
Eligibility
18 Years to 99 Years
Enrollment
411 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Sep 17, 2026, 8:33 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

NCT06816459
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Cigarette smell test, Cigarette Taste Test, Study questionnaires
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Developing a Team-Delivered Intervention for Smoking and Hazardous Drinking for Primary Care Veterans With Cardiovascular Diseases

NCT05275582
View directory record Official record
Conditions
Cigarette Use, Alcohol Use Above Recommended Limits, Cardiovascular Risk Factors (e.g., Hypertension), Cardiovascular Diseases
Interventions
CARE
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Buffalo, New York • Syracuse, New York
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study

NCT00596882
View directory record Official record
Conditions
Smoking Cessation
Interventions
Message Prime
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 1, 2009 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 3 Interventional Results available

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

NCT01406223
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Bupropion, Nicotine patches, Placebo varenicline, Placebo bupropion, Placebo patch
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2017 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Exercise to Enhance Smoking Cessation for Women at the YMCA

NCT01615380
View directory record Official record
Conditions
Smoking
Interventions
CBT+ Contact, CBT+ Exercise
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
408 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 7, 2012 · Synced Sep 17, 2026, 8:33 PM EDT
Recruiting Phase 2 Interventional

Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD

NCT05723588
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy
Device · Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 17, 2026, 8:33 PM EDT
Active, not recruiting Phase 4 Interventional

Bariatric Surgery vs. Semaglutide vs. Tirzepatide

NCT06803888
View directory record Official record
Conditions
Obesity and Obesity-related Medical Conditions
Interventions
Bariatric Surgery, Semaglutide, Tirzepatide
Procedure · Drug
Lead sponsor
Ali Aminian
Other
Eligibility
18 Years to 70 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Curbing Tobacco Use in Suburban and Rural Schools

NCT00513097
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Smoking Prevention Program, Focus Group, Survey
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
14 Years to 16 Years
Enrollment
1,289 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia

NCT00136760
View directory record Official record
Conditions
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Interventions
Bupropion, Contingent reinforcement plus placebo, non-contingent reinforcement plus bupropion, Non-contingent reinforcement plus placebo
Drug
Lead sponsor
Brown University
Other
Eligibility
18 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 6, 2015 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dental Implant Study Comparing Two Types of Metals Used for Dental Implants

NCT01714024
View directory record Official record
Conditions
Tooth Replacement
Interventions
Zimmer Trabecular Metal Test Cylinder, Zimmer Titanium Test Cylinder
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
21 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trial of An Innovative Smartphone Intervention for Smoking Cessation

NCT02724462
View directory record Official record
Conditions
Smoking
Interventions
Smartphone-delivered Intervention (SmartQuit), : Smartphone-delivered Intervention (Standard of care app)
Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
2,503 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 4, 2021 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Quit4Health Intervention in Supporting Smoking Cessation and Preventing Smoking Initiation in Young Adults

NCT04009590
View directory record Official record
Conditions
Cigarette Smoking, Current Smoker
Interventions
Educational Intervention, Questionnaire Administration, Smoking Cessation Intervention
Other · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 35 Years
Enrollment
579 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 21, 2021 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Results available

Tobacco Intervention in Primary Care Treatment Opportunities for Providers

NCT02096029
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Ask, Advise, Refer (physician brief advice)
Other · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
1,278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Results available

Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers

NCT00934024
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varenicline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 9, 2018 · Synced Sep 17, 2026, 8:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers

NCT01692353
View directory record Official record
Conditions
Cardiovascular Disease, Cigarette Smoking
Interventions
Subject's usual brand (UB) tobacco product
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
26 Years to 49 Years · Male only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 16, 2016 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Open-Label, Placebo-Controlled, Parallel Group Study in Healthy Volunteers to Evaluate the Effects of Two Single MT 400 or Naproxen Sodium Tablets

NCT00596245
View directory record Official record
Conditions
Healthy
Interventions
MT400
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 35 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness Training for Smoking Cessation

NCT05440903
View directory record Official record
Conditions
Smoking Cessation
Interventions
Headspace, TEDTalk
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Rimonabant as an Aid to Smoking Cessation With or Without Nicotine Patch

NCT00458718
View directory record Official record
Conditions
Smoking Cessation
Interventions
rimonabant (SR141716)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
755 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 19, 2009 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Faith Moves Mountains: A Community Based Participatory Research (CBPR) Appalachian Wellness & Cancer Prevention Program

NCT01373320
View directory record Official record
Conditions
Lung Cancer, Cervical Cancer, Breast Cancer, Colorectal Cancer
Interventions
Lay health advisor interactions
Behavioral
Lead sponsor
Nancy Schoenberg
Other
Eligibility
18 Years and older
Enrollment
1,415 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Whitesburg, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 22, 2013 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Educating Providers About Lung Screening

NCT05064046
View directory record Official record
Conditions
Lung Cancer
Interventions
LuCa + Health Disparity module
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
Not listed
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Sep 17, 2026, 8:33 PM EDT
Active, not recruiting Not applicable Interventional

A Novel Tobacco Cessation Resource for Smokers With a Diagnosed or Suspected Thoracic Cancer

NCT07455513
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Malignant Thoracic Neoplasm
Interventions
Electronic Health Record Review, Informational Intervention, Interview, Referral, Smoking Cessation Intervention, Survey Administration
Other · Device
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 17, 2026, 8:33 PM EDT
Completed Not applicable Interventional

BABY STEPS II: SMS Scheduled Gradual Reduction Text Messages to Help Pregnant Smokers Quit

NCT01995097
View directory record Official record
Conditions
Smoking, Pregnancy
Interventions
Scheduled Gradual Reduction Text Messages, Support Text Messages
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 7, 2019 · Synced Sep 17, 2026, 8:33 PM EDT
Recruiting Not applicable Interventional

Health Effects of the Standardized Research E-Cigarette in Smokers With HIV Smokers With HIV

NCT03862924
View directory record Official record
Conditions
HIV
Interventions
Standardized Research Electronic Cigarette
Device
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Sep 17, 2026, 8:33 PM EDT