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Showing 1–24 of 707 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Tobacco Use Cessation Clear all
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Innovative Interventions for Smoking Cessation

NCT01050569
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Patch, VLNC Cigarette, VLNC Cigarette Plus Nicotine Patch
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
2
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Sep 19, 2026, 10:08 AM EDT
Terminated Not applicable Interventional

Project QUIT+: Adapting and Testing a Smoking Cessation Intervention for Transgender and Gender Expansive Individuals

NCT06654414
View directory record Official record
Conditions
Smoking Cessation, Depression, Anxiety, Nicotine Dependence, Gender Minority Stress
Interventions
PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
3
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Impact of Smoking Cessation on Sleep - 5

NCT00132821
View directory record Official record
Conditions
Tobacco Use Cessation, Sleep Disorders
Interventions
Bupropion, Transdermal Nicotine Patch, Placebo Bupropion, Placebo transdermal nicotine patch
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
Menlo Park, California
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia

NCT00373126
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
transdermal nicotine patch
Drug
Lead sponsor
North Suffolk Mental Health Association
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2009 · Synced Sep 19, 2026, 10:08 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Semaglutide for Post-Smoking Cessation Weight Management

NCT06173778
View directory record Official record
Conditions
Obesity, Overweight, Cigarette Smoking
Interventions
semaglutide 2.4mg, Placebo, Nicotine Replacement Therapy (NRT, nicotine patch), Brief Smoking Cessation Counseling
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
2
States / cities
Austin, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional

Quit IT: Preliminary Testing of a Web-based, 3D Coping Skills Game to Increase Quitting Self-Efficacy for Maintaining Smoking Abstinence Following Hospitalization

NCT02099097
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
web-based video game (Quit IT), Questionnaires, Salvia sample
Other · Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 29, 2020 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Telephone Counseling for Tobacco Cessation

NCT01489579
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Telephone Counseling for Tobacco Cessation, Usual Care
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 17, 2019 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study

NCT00755716
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Placebo (sugar pill), Topiramate, Nicotine patch
Drug
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 15, 2017 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Countering Young Adult Tobacco Marketing in Bars

NCT01686178
View directory record Official record
Conditions
Smoking Cessation
Interventions
Anti-smoking social marketing campaign
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 26 Years
Enrollment
17,422 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes

NCT03575468
View directory record Official record
Conditions
Smoking Cessation
Interventions
Enhanced E-cigarette Coaching, Quitline treatment as usual
Behavioral
Lead sponsor
Consumer Wellness Solutions
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 19, 2026, 10:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

NCT06395415
View directory record Official record
Conditions
Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions
EQUIP, Standard Care
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Addressing Racial/Ethnic Tobacco Health Disparities Via Group Intervention

NCT02511236
View directory record Official record
Conditions
Smoking Cessation
Interventions
Group Cognitive Behavioral Therapy, General Health Education, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
356 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
2
States / cities
Coral Gables, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional

Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.

NCT02601521
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Internal tobacco coach, External tobacco coach
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 1Phase 2 Interventional Results available

STARS (Smoking Treatment And Remote Sampling) Study

NCT04525755
View directory record Official record
Conditions
Smoking, Smoking Cessation, Tobacco Smoking, Cigarette Smoking
Interventions
Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT)
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
652 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Smoking Tobacco and Drinking Study

NCT03163303
View directory record Official record
Conditions
Smoking, Heavy Episodic Drinking
Interventions
Tobacco Status Project Intervention, Tobacco Status Project + Alcohol Intervention, nicotine patch
Behavioral · Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 25 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Sep 19, 2026, 10:08 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Testing ANSOS for Efficacy in Multi-Tribal Urban Communities

NCT06566703
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
All Nations Snuff Out Smokeless, Healthy Living
Behavioral
Lead sponsor
Lehigh University
Other
Eligibility
18 Years and older
Enrollment
384 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed No phase listed Observational

Comparative Effectiveness Research Study of Peripheral Arterial Disease (PAD)

NCT01378260
View directory record Official record
Conditions
Peripheral Arterial Disease, Claudication
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
21 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
12
States / cities
Bellevue, Washington • Bellingham, Washington • Everett, Washington + 6 more
Source: ClinicalTrials.gov public record
Updated May 17, 2017 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tobacco Treatment Outreach to Reduce Disparities for Primary Care Populations

NCT01156610
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Tobacco Treatment
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
706 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 5, 2014 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Pilot Study Evaluating Nicotine Lozenges and Self Help

NCT00888459
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
nicotine replacement therapy, placebo NRT
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rochester, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Patch, Blood Flow and Oxidative Stress Study

NCT00954096
View directory record Official record
Conditions
Healthy
Interventions
transdermal nicotine patch (7mg)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2009 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

WeChat Quit Coach Pilot Study

NCT05130788
View directory record Official record
Conditions
Smoking Cessation
Interventions
WeChat Quit Coach, Leaflet, Optional Nicotine Replacement Therapy (NRT) Patches or Lozenges
Behavioral · Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Results available

Learn to Quit-HIV Pilot Study

NCT04609514
View directory record Official record
Conditions
HIV/AIDS, Smoking Cessation, Tobacco Use Disorder
Interventions
Learn to Quit-HIV, QuitGuide, Nicotine patch, Smartphone coaching
Device · Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 18, 2023 · Synced Sep 19, 2026, 10:08 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Randomized Trial of Internet Access to Nicotine Patches

NCT00534404
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Disorder
Interventions
Nicotine patches, Telephone counseling, iQuit Smoking website
Drug · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
2,485 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 2, 2015 · Synced Sep 19, 2026, 10:08 AM EDT