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ClinicalTrials.gov public records Last synced Oct 10, 2026, 11:31 PM EDT

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Showing 25–48 of 67 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Tobacco and non-tobacco e-cigarettes Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)

NCT07721883
View directory record Official record
Conditions
Perceptions of Tobacco Products
Interventions
Each intervention will be a picture of a social media post. The posts will vary (in a 3X2 factorial design) the type of flavor described and whether concealability is described.
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
14 Years to 17 Years
Enrollment
4,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarette Switching Older Adults

NCT06534905
View directory record Official record
Conditions
Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
Interventions
E-cigarette, Control/Standard Advice
Other · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Smoke-free Home Study in Subsidized Housing

NCT06170437
View directory record Official record
Conditions
Tobacco Dependence, Tobacco Smoking
Interventions
Smoke-free home resident intervention, Lay Health Worker coaching
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
544 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Oct 10, 2026, 11:31 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study

NCT06503159
View directory record Official record
Conditions
Vaping Teens, Healthy Volunteers
Interventions
Mindfulness-based Stress Reduction (MBSR) Program, functional magnetic resonance imaging (fMRI)
Behavioral · Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Phase 1 Interventional Results available

Effects of E-cigarette Flavors on Youth TCORS 2.0

NCT03634839
View directory record Official record
Conditions
Nicotine Use Disorder
Interventions
Flavoring Agents, Nicotine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Oct 10, 2026, 11:31 PM EDT
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Recruiting Phase 4 Interventional

The Avenues Study: Dual Use Cessation

NCT06474299
View directory record Official record
Conditions
Smoking Cessation, Electronic Cigarette Use
Interventions
Varenicline, Nicotine patch, Dual Focused Cessation Counseling, Smoking Focused Cessation Counseling, Counseling Intensity: 1 Session, Counseling Intensity: 4 Sessions
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

NCT02102100
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 19, 2020 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional

C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)

NCT04358705
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey, Online Experimental Marketplace (ETM), Aim 3 survey, Cognitive Interviews, Supplemental Aim 1 Interviews
Other · Behavioral
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
16 Years to 28 Years
Enrollment
658 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional

Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults

NCT02498145
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Nicotine e-cigarette, Non-nicotine e-cigarette
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine and Cannabis Vape Labeling Experiment - Spring 2025

NCT06919276
View directory record Official record
Conditions
Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions
Vaping Device Labeling
Other
Lead sponsor
University of Southern California
Other
Eligibility
11 Years to 19 Years
Enrollment
3,048 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)

NCT03453385
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Electronic Cigarette
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
638 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2023 · Synced Oct 10, 2026, 11:31 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Switch or Quit R01

NCT06373679
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Switching to E-Cigarette, Switching using Medication
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Impact of Chronic E-Cigarette Usage on Microvascular Health

NCT06860698
View directory record Official record
Conditions
E-Cig Use
Interventions
E-cig use
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 29 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD200907: A Study to Assess Elements of Abuse Liability for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants

NCT05114863
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions
Product A1, Product B, Product C, Product D, Product A2, Product E, Product F, Product G, Product H, Product N
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 27, 2022 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use

NCT03402243
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2021 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors

NCT02000921
View directory record Official record
Conditions
Tobacco Addiction, Dual Tobacco Use
Interventions
VLNC cigarettes, Combusted Products, Non-combusted products, CN cigarettes
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
136 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 31, 2017 · Synced Oct 10, 2026, 11:31 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping Status

NCT07038317
View directory record Official record
Conditions
Vaping Behaviors, Message Exposure, Young Adults
Interventions
Intervention, Control
Other
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 24 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BAT3221032: A Study to Evaluate the Effects of Switching From Cigarette Smoking to Using One of Five Variants of a Heated Tobacco Product on Biomarkers of Exposure and Biomarkers of Potential Harm in Healthy Subjects

NCT05142436
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A: Non-Combusted Cigarette Variant 42001402 and product use Mode B, Product B: Non-Combusted Cigarette Variant 42001399 and product use Mode B, Product C: Non-Combusted Cigarette Variant 42001401 and product use Mode B, Product D: Non-Combusted Cigarette Variant 40007386 and product use Mode B, Product E: Non-Combusted Cigarette Variant 42001402 and product use Mode A
Other
Lead sponsor
British American Tobacco (Investments) Limited
Industry
Eligibility
26 Years to 55 Years
Enrollment
806 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
18
States / cities
Bentonville, Arkansas • Little Rock, Arkansas • Rogers, Arkansas + 14 more
Source: ClinicalTrials.gov public record
Updated Dec 16, 2022 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes

NCT04188197
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking, Tobacco Dependence, Tobacco Use Cessation
Interventions
JUUL
Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2025 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Results available

A Trial of E-cigarettes in Current Cigarette Smokers

NCT02357173
View directory record Official record
Conditions
Smoking, Nicotine Dependence, Nicotine Dependence, Other Tobacco Product
Interventions
electronic cigarette, cigarette group
Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional Results available

Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace

NCT05110872
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cigarette flavor restricted and e-cigarette flavor restricted, Cigarette flavor restricted and e-cigarette flavor unrestricted, Cigarette flavor unrestricted and e-cigarette flavor restricted, Cigarette flavor unrestricted and e-cigarette flavor unrestricted
Behavioral
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
21 Years and older
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Oct 10, 2026, 11:31 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biology of the Oral Epithelium of E-Cigarette Smokers

NCT03028558
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years to 35 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2021 · Synced Oct 10, 2026, 11:31 PM EDT
Completed Not applicable Interventional

Potential Impact of Menthol Ban in Cigarettes and E-cigarettes

NCT05259566
View directory record Official record
Conditions
Tobacco Smoking
Interventions
menthol ban in cigarettes only, total menthol ban
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 10, 2026, 11:31 PM EDT