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Showing 1–24 of 43 matching trials from the live ClinicalTrials.gov search.
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Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of an Anticavity Low pH Mouthwash

NCT06010758
View directory record Official record
Conditions
Healthy
Interventions
Listerine Experimental Mouthwash, Colgate Cavity Protection Toothpaste, Listerine Total Care Zero, Listerine Cool Mint Zero
Drug · Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 2 Interventional

Strategies to Prevent Pneumonia (SToP Pneumonia)

NCT00234598
View directory record Official record
Conditions
Ventilator Associated Pneumonia
Interventions
Toothbrushing only, Chlorhexidine only, Toothbrushing and Chlorhexidine
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
547 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Sep 11, 2026, 10:44 AM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis

NCT03421145
View directory record Official record
Conditions
Plaque
Interventions
3M™ Oral Rinse, Vehicle Control Oral Rinse, PerioShield™ Oral Health Rinse, Water
Device · Other
Lead sponsor
Solventum US LLC
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Plaque Removal Efficacy of Four Dentifrices Following a Single Brushing

NCT04794439
View directory record Official record
Conditions
Plaque, Dental
Interventions
Dentifrices
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2021 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

IFI16 is a Periodontitis Modulating Protein

NCT03513497
View directory record Official record
Conditions
Severe Periodontitis, Acute Inflammatory Response
Interventions
Customized acrylic mouthguard
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 11, 2026, 10:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Safety and Efficacy of Flaus Electric Flosser on Plaque and Gingivitis Compared to a Manual Toothbrush

NCT07779564
View directory record Official record
Conditions
Gingivitis, Gingival Bleeding, Dental Plaque
Interventions
Electric Flosser, Manual Toothbrush
Device
Lead sponsor
Flaus, Inc
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Asthma in Central Texas Project

NCT01676896
View directory record Official record
Conditions
Asthma
Interventions
Asthma in-school class, Asthma Day Camp, Health Promotion in-school class
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
6 Years to 13 Years
Enrollment
292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Twelve Week Study of Virtually Supervised Mouth Rinse and Flossing

NCT04750005
View directory record Official record
Conditions
Healthy
Interventions
Listerine Cool Mint, Colgate Cavity Protection Toothpaste, Reach Unflavored Waxed Dental Floss, American Dental Association (ADA) Ref Toothbrush
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years to 60 Years
Enrollment
209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries

NCT06949072
View directory record Official record
Conditions
Dental Caries
Interventions
Test Dentifrice, Reference Dentifrice, Negative Control Dentifrice
Drug
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Atlas of Experimental Gingivitis in Humans

NCT04105569
View directory record Official record
Conditions
Gingivitis
Interventions
Stent-Induced Biofilm Overgrowth
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 30 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2020 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

The Effect of Sonophoresis on Topical Anesthesia: A Pilot Study

NCT01283490
View directory record Official record
Conditions
Topical Anesthetic Applied With Sonophoresis
Interventions
DASD Group, Sonic Vibration (SV)
Device
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2016 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis

NCT03219840
View directory record Official record
Conditions
Gingivitis, Plaque, Dental, Periodontal Diseases
Interventions
Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum, Xylitol only chewing gum
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2021 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional

Effectiveness of Ortho-Buddy on Plaque Control in Orthodontic Patients

NCT07810868
View directory record Official record
Conditions
Orthodontic Patients With Fixed Appliances
Interventions
Standard Toothbrush, Ortho-Buddy
Device
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
11 Years to 18 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Science Tooth Fairy: A Randomized Trial of a Storytelling-Based Educational Intervention to Promote Primary Tooth Donation in a Pediatric Setting

NCT07711301
View directory record Official record
Conditions
Health Knowledge, Attitudes, Practices
Interventions
Science Tooth Fairy Narrative, Cavities vs. Toothpaste, book by Didi Dragon
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)

NCT02366689
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste, Cetylpyridinium chloride mouthwash, Fluoride only mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
179 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 29, 2016 · Synced Sep 11, 2026, 10:44 AM EDT
Recruiting No phase listed Observational

Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer

NCT00898313
View directory record Official record
Conditions
Lung Cancer
Interventions
comparative genomic hybridization, gene expression microarray analysis, proteomic profiling analysis, biologic sample preservation procedure, nasal brushing, Blood draw, Urine collection, sputum sample, fluorescence bronchoscopy with airway biopsy, fine needle aspiration of the lung, thoracentesis
Genetic · Other · Procedure
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
18 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2027
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional

Randomized Trial of a Gum Health Formulation

NCT03196648
View directory record Official record
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Sep 11, 2026, 10:44 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

A Prospective Registry for Patients at High-Risk for Pancreatic Cancer

NCT06151223
View directory record Official record
Conditions
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
Interventions
Bio-specimen Collection: Blood, Bio-specimen Collection: Pancreatic Juice, MRI
Other · Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2031
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Digital vs. Parent Modeled Toothbrushing

NCT07441148
View directory record Official record
Conditions
Plaque Reduction
Interventions
MoodBrush Digital Application
Device
Lead sponsor
University of Southern California
Other
Eligibility
3 Years to 6 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Study of Tooth Erosion in People With Esophagogastric Cancer

NCT05612048
View directory record Official record
Conditions
Esophagogastric Cancer
Interventions
Survey, Intra-oral camera, Optional Salvia sample
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional

A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients

NCT03886623
View directory record Official record
Conditions
Methicillin-resistant Staphylococcus Aureus, Methicillin-Sensitive Staphylococcus Aureus Infection
Interventions
4-day systematic oral hygiene, Standard of Care oral care
Procedure · Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Determination of the Oral Irritation Potential of a Fluoride Rinse in Children

NCT06798441
View directory record Official record
Conditions
Healthy
Interventions
Brush Only, Brush / Rinse (Jolly Rancher Prototype), Brush / Rinse (LISTERINE® Total Care Zero Alcohol)
Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
6 Years to 11 Years
Enrollment
161 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing if Tartarase Can Remove Dental Tartar

NCT06139835
View directory record Official record
Conditions
Dental Calculus
Interventions
Tartarase
Biological
Lead sponsor
Pontis Biologics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Huntington, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 11, 2026, 10:44 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Virtually Supervised Mouth Rinses and Flossing

NCT05600231
View directory record Official record
Conditions
Healthy
Interventions
LISTERINE COOL MINT Antiseptic Mouthwash, LISTERINE COOL MINT ZERO Alcohol Mouthwash, Reach Unflavored Waxed Dental Floss, Colgate Cavity Protection Toothpaste
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
284 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2023 · Synced Sep 11, 2026, 10:44 AM EDT