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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Toothpaste Clear all
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

NCT05482256
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
Esophageal String Test (EST), Colgate, High Resolution Esophageal Manometry (HREM)
Diagnostic Test · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional

Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis

NCT04998617
View directory record Official record
Conditions
Halitosis
Interventions
Toothpaste with curcumin, Toothpaste without curcumin
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Triclosan Toothpaste and Third Molar Surgery

NCT01292343
View directory record Official record
Conditions
Dry Socket, Wound Infection
Interventions
Colgate Total Toothpaste, Colgate Regular Toothpaste
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 35 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Correlation Between Oral Health and Systemic Inflammation (COHESION)

NCT03641989
View directory record Official record
Conditions
Inflammation, Periodontal Disease, Gingivitis
Interventions
Plaque disclosing toothpaste, Non-plaque disclosing toothpaste
Other
Lead sponsor
Marshfield Clinic Research Foundation
Other
Eligibility
21 Years to 84 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Marshfield, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Next Science Antimicrobial Mouth Rinse Study

NCT03154021
View directory record Official record
Conditions
Gingivitis, Dental Plaque
Interventions
Next Science OTC Oral Rinse with Essential Oils, OTC Oral Rinse Control
Combination Product
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 60 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 17, 2019 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of an Oral Probiotic Intervention With or Without a Novel ADP-1 Toothpaste

NCT05330793
View directory record Official record
Conditions
Oral Health
Interventions
Oral probiotic, Placebo
Dietary Supplement
Lead sponsor
USANA Health Sciences
Industry
Eligibility
18 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
South Jordan, Utah
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Livionex on Reducing Plaque Accumulation and Improving Oral Health in Children

NCT04368533
View directory record Official record
Conditions
Plaque, Dental, Caries, Dental, Oral Hygiene
Interventions
Livionex Dental Gel, A standard children's toothpaste containing 1500 ppm fluoride
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
9 Months to 12 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

NCT05645705
View directory record Official record
Conditions
Healthy
Interventions
Colgate Cavity Protection Toothpaste, LISTERINE Cool Mint Antiseptic Mouthwash, Listerine Advanced Gum Alcohol, Listerine Advanced Gum Zero, LISTERINE ULTRACLEAN Tartar Control Antiseptic Mouthwash Cool Mint
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 9, 2023 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Salivary Inflammatory Biomarkers: Predictors & Comparative Effects of Sonicare/Elite-Flexcare in Stages of Perio Disease

NCT02187185
View directory record Official record
Conditions
Inflammation, Periodontitis
Interventions
Sonicare/Elite-Flexcare Toothbrush, Manual Toothbrush
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 75 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Arginine Plaque Metabolism Pilot Clinical Study

NCT06954779
View directory record Official record
Conditions
Plaque, Dental
Interventions
Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Piscataway, New Jersey
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Purpose of This Research Study is to Compare the Effectiveness of a Non-fluoride Whitening Toothpaste (Test) to That of a Non-whitening Fluoride Toothpaste (Negative Control) in Improving Tooth Whiteness (Removal of Extrinsic Stains) Over 8 Weeks of Unsupervised Use.

NCT07219342
View directory record Official record
Conditions
Teeth Staining
Interventions
Toothpaste
Other
Lead sponsor
Boka LLC
Industry
Eligibility
18 Years to 65 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Results available

Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity

NCT02113579
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Mouth Rinse 12027-033, Placebo Mouth Rinse
Device · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
2
States / cities
Fort Wayne, Indiana • Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis

NCT01224158
View directory record Official record
Conditions
Dental Devices, Home Care
Interventions
Experimental Power Toothbrush, Flat trimmed Manual Toothbrush
Device
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional

Randomized Trial of a Gum Health Formulation

NCT03196648
View directory record Official record
Conditions
Periodontal Diseases, Gingivitis, Periodontitis, Halitosis
Interventions
Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste
Other
Lead sponsor
Glo Science, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms

NCT02207400
View directory record Official record
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate and sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Sep 4, 2026, 12:39 AM EDT
Not yet recruiting Not applicable Interventional

Impact of an Arginine-containing Toothpaste on the Subgingival Microbiota in Patients in Supportive Periodontal Care

NCT07755800
View directory record Official record
Conditions
Gum Disease
Interventions
Arginine Toothpaste, Fluoride Toothpaste
Device
Lead sponsor
Sukirth M Ganesan, BDS, PhD
Other
Eligibility
18 Years to 95 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Toothbrush Bristles in Plaque Reduction

NCT04681885
View directory record Official record
Conditions
Plaque, Dental, Gingivitis
Interventions
Tapered bristles A, Tapered bristles B, End rounded bristles
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing if Tartarase Can Remove Dental Tartar

NCT06139835
View directory record Official record
Conditions
Dental Calculus
Interventions
Tartarase
Biological
Lead sponsor
Pontis Biologics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Huntington, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 4, 2026, 12:39 AM EDT
Completed No phase listed Interventional Accepts healthy volunteers Results available

Measuring Efficacy of an Oral-Irrigator After Three Weeks of Use

NCT04899440
View directory record Official record
Conditions
Gingivitis, Plaque
Interventions
Water Flosser, Control
Device · Other
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2022 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI)

NCT05782348
View directory record Official record
Conditions
Adolescent Behavior, Dental Plaque, Gingivitis, Cognitive Change
Interventions
Cognitive behavioral intervention, Colgate smart toothbrush
Behavioral · Other
Lead sponsor
Howard University
Other
Eligibility
14 Years to 17 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Investigate Oral Bacteria in Adult Population

NCT00762177
View directory record Official record
Conditions
Oral Bacteria
Interventions
Fluoride, Fluoride, Triclosan, Stannous Fluoride
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Newark, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2011 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal

NCT02151058
View directory record Official record
Conditions
Tooth Stain
Interventions
Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
Drug · Other
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years to 65 Years
Enrollment
227 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 31, 2015 · Synced Sep 4, 2026, 12:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Sep 4, 2026, 12:39 AM EDT