Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results come from ClinicalTrials.gov. When the live registry is unavailable, a clearly labeled stored copy may be shown.

Clear filters

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 11:09 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 230 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Toothpaste Clear all
Completed No phase listed Observational Accepts healthy volunteers

Meta-analysis of Stannous Fluoride and the Effects on Gingival Health

NCT03970759
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous Fluoride Dentifrice, Positive control dentifrice, Negative control dentifrice
Drug
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
2,890 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing

NCT00855933
View directory record Official record
Conditions
Gingivitis
Interventions
Experimental Floss
Device
Lead sponsor
Procter and Gamble
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2013 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluating Commercial Anti-Plaque Products and Oral Rinse

NCT01014143
View directory record Official record
Conditions
Dental Plaque
Interventions
Fluoride, Chlorhexidine digluconate, Fluoride, triclosan
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
23 Years to 81 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Northfield, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation

NCT04155658
View directory record Official record
Conditions
Enamel Caries
Interventions
Experimental Toothpaste containing 1450ppm SMFP, Toothpaste containing 1450ppm SMFP, Toothpaste with no fluoride
Other
Lead sponsor
Unilever R&D
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US

NCT02360995
View directory record Official record
Conditions
Dental Plaque, Gingivitis
Interventions
Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste, Fluoride Mouthwash, cetylpyridinium chloride Mouthwash
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2016 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Application (IOA) Testing Study of a Stannous Toothpaste

NCT07419672
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Treatment Slurry (Fluoride-Free), Active Comparator Fluoride Treatment (0.454% SnF), Test Fluoride Treatment (0.454% SnF) (Investigational Toothpaste)
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity

NCT01592851
View directory record Official record
Conditions
Dentine Hypersensitivity
Interventions
Stannous Fluoride, Sodium Monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
113 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 19, 2026, 11:09 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Real-World Study of a Calcium Sodium Phosphosilicate Anti-Sensitivity Toothpaste for Dentin Hypersensitivity Relief

NCT07300540
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Calcium sodium phosphosilicate (CSPS) Toothpaste
Other
Lead sponsor
HALEON
Industry
Eligibility
18 Years to 65 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

In Situ Caries Efficacy of Fluoride Toothpastes

NCT00708097
View directory record Official record
Conditions
Caries
Interventions
NaF, Placebo, NaMFP
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 78 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children

NCT04750902
View directory record Official record
Conditions
Dental Caries
Interventions
0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice, 8.0% Arginine Dentifrice
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
10 Years to 14 Years
Enrollment
2,025 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
8
States / cities
Loma Linda, California • Gainesville, Florida • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Compare the Clinical Efficacy of Prototype Toothpastes

NCT00926029
View directory record Official record
Conditions
Dental Plaque
Interventions
Fluoride, Triclosan, fluoride, Metal salt
Drug · Other
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Cedar Knolls, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2012 · Synced Oct 19, 2026, 11:09 PM EDT
Enrolling by invitation Not applicable Interventional

Impact of an Arginine-containing Toothpaste on the Subgingival Microbiota in Patients in Supportive Periodontal Care

NCT07755800
View directory record Official record
Conditions
Gum Disease
Interventions
Arginine Toothpaste, Fluoride Toothpaste
Device
Lead sponsor
Sukirth M Ganesan, BDS, PhD
Other
Eligibility
18 Years to 95 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

To Evaluate Efficacy and Tolerability of Sodium Bicarbonate Toothpaste and Its Effect on Opportunistic or Resistant Organisms

NCT02207400
View directory record Official record
Conditions
Oral Hygiene
Interventions
Sodium bicarbonate and sodium fluoride, Sodium fluoride
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
246 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluation of the Fluoride Dose Response of a Modified In Situ Caries Model

NCT03383783
View directory record Official record
Conditions
Caries
Interventions
0 ppm F (placebo, negative control), 250 ppm F as NaF (dose-response control), 500 ppm F as NaF (dose-response control), 1100 ppm F as NaF (positive control)
Drug
Lead sponsor
Domenick Zero
Other
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes

NCT00708305
View directory record Official record
Conditions
Dental Caries
Interventions
Sodium Fluoride (NaF), Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

NCT07419685
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index

NCT05805865
View directory record Official record
Conditions
Gingival Inflammation
Interventions
Toothpaste Tablet, Conventional Toothpaste
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2025 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion

NCT07442136
View directory record Official record
Conditions
Enamel Erosion
Interventions
New Toothpaste Containing SnF, Fluoride Toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride

NCT04123665
View directory record Official record
Conditions
Gingivitis
Interventions
Stannous fluoride, Sodium monofluorophosphate
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 31, 2020 · Synced Oct 19, 2026, 11:09 PM EDT
Recruiting Not applicable Interventional

THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

NCT07271381
View directory record Official record
Conditions
Allergic, Inflammatory
Interventions
Environmental Exposures, Control Exposures
Other
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.

NCT02651467
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5), Placebo Oral Rinse (0% w/w KOX 0ppm F, pH 4.5 )
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 27, 2018 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste

NCT04033575
View directory record Official record
Conditions
Gingivitis
Interventions
Colgate Total SF, Colgate Cavity Protection toothpaste
Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
18 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Melbourne, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Results available

A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device

NCT01345292
View directory record Official record
Conditions
Dentin Sensitivity
Interventions
Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
226 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 19, 2026, 11:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Oral Tissue Tolerance of a Mouthrinse

NCT01009554
View directory record Official record
Conditions
Dental Health
Interventions
Potassium Oxylate Mouthwash, Sodium Fluoride Dentifrice
Device · Drug
Lead sponsor
Johnson & Johnson Consumer and Personal Products Worldwide
Industry
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Paramus, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 3, 2015 · Synced Oct 19, 2026, 11:09 PM EDT