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Showing 1–24 of 144 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Total Shoulder Arthroplasty Clear all
Recruiting Phase 4 Interventional

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

NCT06143306
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
bupivacaine., Saline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Not applicable Interventional Results available

Dermabond PRINEO for Total Shoulder Arthroplasty

NCT03860181
View directory record Official record
Conditions
Surgical Wound, Shoulder Arthritis, Surgical Incision
Interventions
Subcuticular Sutures - Surgeon 1, Metal Staples - Surgeon 2, PRINEO - Surgeon 1, PRINEO - Surgeon 2
Procedure · Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Sep 28, 2026, 3:49 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Closure After Total Shoulder Arthroplasty: Prineo vs Dermabond

NCT03899753
View directory record Official record
Conditions
Shoulder Arthritis, Shoulder Arthropathy Associated With Other Conditions
Interventions
2-Octyl Cyanoacrylate and Mesh, 2-Octyl Cyanoacrylate
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 28, 2026, 3:49 AM EDT
Terminated No phase listed Observational

Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder Arthroplasty

NCT01480453
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture, Irreducible 3- and 4-part Proximal Humeral Fractures, Avascular Necrosis
Interventions
Trabecular Metal Humeral Stem
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
3
States / cities
Louisville, Kentucky • Royal Oak, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Sep 28, 2026, 3:49 AM EDT
Recruiting No phase listed Observational

Hospital for Special Surgery Shoulder Arthroplasty Cohort

NCT00527839
View directory record Official record
Conditions
Shoulder Arthroplasty
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Recruiting Not applicable Interventional

Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

NCT07406893
View directory record Official record
Conditions
Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
Interventions
Prontosan Wound Gel
Device
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Terminated Not applicable Interventional

Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

NCT02597972
View directory record Official record
Conditions
Closed Fracture Proximal Humerus, Four Part
Interventions
Fracture repair, Fracture repair with joint replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 28, 2026, 3:49 AM EDT
Active, not recruiting Not applicable Interventional

Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty

NCT03726554
View directory record Official record
Conditions
Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects, Post-Traumatic Arthritis
Interventions
Comprehensive Reverse Porous Augmented Glenoid, Comprehensive Mini Humeral Tray
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
6
States / cities
Gulf Breeze, Florida • Louisville, Kentucky • Royal Oak, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Enrolling by invitation No phase listed Observational

MDR - Comprehensive Primary/Micro Stem & Versa-Dial Ti Humeral Head

NCT04003311
View directory record Official record
Conditions
Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Disease, Shoulder Arthritis
Interventions
Comprehensive Primary Micro Stem, Comprehensive Anatomic Versa-Dial Titanium Humeral Head
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
4
States / cities
Boise, Idaho • Royal Oak, Michigan • Rochester, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Not applicable Interventional Results available

Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?

NCT03115177
View directory record Official record
Conditions
Osteoarthritis
Interventions
Doxycycline, Cefazolin
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
40 Years to 90 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 14, 2018 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Phase 4 Interventional Results available

Analgesia After Total Shoulder Arthroplasty

NCT01782872
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Interscalene Block (ISB) - 0.375% Ropivacaine + additives, Interscalene Block (ISB) - 0.2% Ropivacaine + additives, Interscalene Block (ISB) - 0.1% Ropivacaine + additives, Interscalene Block (ISB) - Systemic Control
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Phase 4 Interventional

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.

NCT06109415
View directory record Official record
Conditions
Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia
Interventions
HTX-011, Bupivacaine Hydrochloride, Ibuprofen, Acetaminophen, Luer lock applicator
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
5
States / cities
Little Rock, Arkansas • Jenks, Oklahoma • Bellaire, Texas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Sep 28, 2026, 3:49 AM EDT
Completed No phase listed Observational

Reverse Shoulder Replacement: Age 60 or Younger Outcomes

NCT03148184
View directory record Official record
Conditions
Shoulder Arthritis
Interventions
shoulder x-ray
Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2019 · Synced Sep 28, 2026, 3:49 AM EDT
Withdrawn Not applicable Interventional

Anatomic Versus Reverse Shoulder Arthroplasty for Primary Glenohumeral Osteoarthritis

NCT06513559
View directory record Official record
Conditions
Glenohumeral Osteoarthritis
Interventions
Anatomic total shoulder replacement, Reverse total shoulder replacement
Device
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Sep 28, 2026, 3:49 AM EDT
Completed No phase listed Observational Results available

Prediction of Development of Scapular Notching Following Reverse Total Shoulder Arthroplasty

NCT02052466
View directory record Official record
Conditions
Osteoarthritis, Rotator Cuff Tear Arthropathy, Reverse Total Shoulder Arthroplasty, Scapular Notching
Interventions
Not listed
Lead sponsor
Eric Ricchetti
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Phase 4 Interventional Results available

LIBERATE - LIposomal Bupivacaine vERsus Adjuncts in Total shouldErs

NCT03887650
View directory record Official record
Conditions
Post-operative Pain, Total Shoulder Arthroplasty, Osteoarthritis of the Shoulder, Pain Management
Interventions
Liposomal Bupivicaine 1.3%, Bupivacaine 0.5%
Drug
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 100 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Sep 28, 2026, 3:49 AM EDT
Terminated Not applicable Interventional Results available

Total vs. Reverse Shoulder Replacement: Pain Relief Two Years After Surgery

NCT01884077
View directory record Official record
Conditions
Arthritis
Interventions
Reverse Shoulder Arthroplasty, Total Shoulder Arthroplasty
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
70 Years to 95 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced Sep 28, 2026, 3:49 AM EDT
Terminated No phase listed Observational Results available

A Post-Market Clinical Evaluation of the ReUnion TSA System

NCT03858517
View directory record Official record
Conditions
Shoulder Arthroplasty
Interventions
ReUnion TSA System
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years to 99 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
3
States / cities
Peoria, Illinois • Nashville, Michigan • Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 30, 2025 · Synced Sep 28, 2026, 3:49 AM EDT
Recruiting Not applicable Interventional

A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

NCT07584356
View directory record Official record
Conditions
Shoulder Arthritis
Interventions
aTSA, rTSA
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years to 85 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Recruiting Not applicable Interventional

Post-incision Antimicrobial Wash vs C. Acnes in Shoulder Arthroplasty

NCT06831422
View directory record Official record
Conditions
Shoulder Arthroplasty, Positive C. Acnes Culture
Interventions
Povidone-Iodine, Hydrogen Peroxide, Xperience Antimicrobial Wash, Bacterial Cultures, Shoulder Arthroplasty
Device · Diagnostic Test · Procedure
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Phase 4 Interventional Results available

Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty

NCT05005260
View directory record Official record
Conditions
Pain, Postoperative, Brachial Plexus Block
Interventions
Bupivacaine HCl, Liposomal bupivacaine + Bupivacaine Hcl 0.5% Inj
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Not applicable Interventional Results available

Sidus Stem-Free Shoulder IDE Study

NCT01878253
View directory record Official record
Conditions
Osteoarthritis, Posttraumatic Arthrosis, Rheumatoid Arthritis
Interventions
Sidus Stem-Free Total Shoulder Arthroplasty System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
22 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
8
States / cities
Redwood City, California • San Francisco, California • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2019 · Synced Sep 28, 2026, 3:49 AM EDT
Completed No phase listed Observational

Electromyography Evaluation of Subscapularis Function After Total Shoulder Arthroplasty

NCT00779974
View directory record Official record
Conditions
Osteoarthritis
Interventions
Evaluation
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
45 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Sep 28, 2026, 3:49 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty

NCT02876055
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 15, 2019 · Synced Sep 28, 2026, 3:49 AM EDT