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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Total Thyroidectomy Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Does Preoperative Calcium and Calcitriol Decrease Rates of Post Thyroidectomy Hypocalcemia?

NCT03869398
View directory record Official record
Conditions
Hypocalcemia, Thyroid Diseases
Interventions
Tums, Calcitriol
Dietary Supplement
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 8, 2019 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

Diagnostic Accuracy of Shear-Wave Elastography for the Preoperative Risk Stratification of Follicular Lesions of the Thyroid

NCT03106337
View directory record Official record
Conditions
Thyroid Nodule, Follicular Neoplasm
Interventions
Shear-Wave Elastography
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy

NCT05022667
View directory record Official record
Conditions
Thyroid Neoplasms, Thyroid Diseases, Hypoparathyroidism, Endocrine System Diseases, Endocrine Gland Neoplasms, Neoplasms by Site, Neoplasms, Head and Neck Neoplasms, Parathyroid Diseases
Interventions
PTeye
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Sep 7, 2026, 4:17 PM EDT
Recruiting No phase listed Observational

Development of Liquid Biopsy Technologies for Noninvasive Cancer Diagnostics in Patients With Suspicious Thyroid Nodules or Thyroid Cancer

NCT04742608
View directory record Official record
Conditions
Thyroid Gland Carcinoma, Thyroid Gland Nodule
Interventions
Biospecimen Collection, Electronic Health Record Review
Procedure · Other
Lead sponsor
Jonsson Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Sep 7, 2026, 4:17 PM EDT
Withdrawn Not applicable Interventional

Trial Evaluating Use of Arista in Total Thyroidectomy

NCT02568085
View directory record Official record
Conditions
Thyroidectomy, Seroma
Interventions
Arista
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2019 · Synced Sep 7, 2026, 4:17 PM EDT
Terminated No phase listed Observational

Is Levothyroxine Alone Adequate Thyroid Hormone Replacement?

NCT02567877
View directory record Official record
Conditions
Postsurgical Hypothyroidism, Hypothyroidism
Interventions
thyroidectomy, levothyroxine in thyroidectomy patients
Procedure · Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Phase 2 Interventional Results available

Thyroid and Glucose and Energy Metabolism

NCT00106119
View directory record Official record
Conditions
Thyroid Diseases
Interventions
Liothyronine and Levothyroxine
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 22, 2015 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Phase 2 Interventional

Molecular Testing to Direct Extent of Initial Thyroid Surgery

NCT02947035
View directory record Official record
Conditions
Thyroid Cancer
Interventions
Thyroid lobectomy, Total thyroidectomy with CCND
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Sep 7, 2026, 4:17 PM EDT
Terminated Phase 3 Interventional Results available

Does Potassium Iodide (SSKI) Reduce Vascularity in Graves' Thyroidectomy?

NCT04080505
View directory record Official record
Conditions
Graves Disease
Interventions
SSKI- Potassium Iodide
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy.

NCT04281875
View directory record Official record
Conditions
Postoperative Hypoparathyroidism, Thyroid Neoplasms, Thyroid Cancer
Interventions
NIRAF Detection Technology
Device
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Sep 7, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

Assessing Patient Satisfaction and Confidence After Use of Educational Video to Augment Surgical Consent for Thyroid Surgery

NCT06918223
View directory record Official record
Conditions
Thyroid Cancer
Interventions
Thyroid Informed Surgical Consent Augmenting Video (TISCAV), Standard Consent
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Sep 7, 2026, 4:17 PM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Atypia of Undetermined Significance (AUS) / Follicular Lesion of Undetermined Significance (FLUS)

NCT03224754
View directory record Official record
Conditions
Diagnoses Disease
Interventions
Determination of risk of malignancy of these thyroid lesions
Behavioral
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated May 10, 2018 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional

Molecular Analysis for Precision Surgery in Thyroid Cancer Trial

NCT06235814
View directory record Official record
Conditions
Papillary Thyroid Cancer
Interventions
Molecular Analysis for Thyroid Resection
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Phase 2 Interventional

Phase II Pre-operative Vitamin D Supplementation to Prevent Post-thyroidectomy Hypocalcemia

NCT01868750
View directory record Official record
Conditions
Thyroid Nodules, Hypocalcemia
Interventions
Calcitriol, Control Pill
Dietary Supplement
Lead sponsor
David Shonka, MD
Other
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Sep 7, 2026, 4:17 PM EDT
Terminated Phase 2 Interventional Results available

Total Thyroidectomy With and Without Prophylactic Central Neck Lymph Node Dissection in People With Low-risk Papillary Thyroid Cancer

NCT02408887
View directory record Official record
Conditions
Low-risk Papillary Thyroid Cancer, Endocrine Malignancy, Thyroid Cancer
Interventions
Total Thyroidectomy (TT), Prophylactic central neck lymph node dissection (pCND)
Procedure
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 26, 2022 · Synced Sep 7, 2026, 4:17 PM EDT
Active, not recruiting No phase listed Observational

Measuring Patient Expectations for Thyroid Surgery

NCT01412762
View directory record Official record
Conditions
Thyroid Cancer
Interventions
patient interviews, CITSAV survey
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 7, 2026, 4:17 PM EDT
Recruiting Not applicable Interventional

Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy

NCT06383091
View directory record Official record
Conditions
Total Thyroidectomy
Interventions
Anterior Neck Manual Therapy, Pain Neuroscience Education, Neck Stretches, Scar massage, Voice Exercises, Placebo Anterior Neck Manual Therapy, Placebo Pain Neuroscience Education, Placebo Neck Stretches
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing Benefits of NIRAF Detection for Identifying Parathyroid Glands During Total Thyroidectomy

NCT05579782
View directory record Official record
Conditions
Postoperative Hypoparathyroidism, Thyroid Disease, Thyroid Neoplasms, Thyroid Cancer
Interventions
NIRAF Detection Technology
Device
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Phase 2 Interventional Results available

Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer

NCT02138214
View directory record Official record
Conditions
Stage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer, Stage III Papillary Thyroid Cancer
Interventions
Thyroidectomy, entral lymph node dissection (CLND), Quality-of-life assessment
Procedure · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years to 73 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 20, 2020 · Synced Sep 7, 2026, 4:17 PM EDT
Completed No phase listed Observational

Predictive Factors for Medullary Thyroid Cancer Aggressiveness

NCT06292988
View directory record Official record
Conditions
Medullary Thyroid Cancer
Interventions
Total Thyroidectomy
Procedure
Lead sponsor
Aristotle University Of Thessaloniki
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Oregon City, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 2, 2025 · Synced Sep 7, 2026, 4:17 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

ENDOblock: Bilateral Superficial Cervical Blocks With Local Wound Infiltration in Thyroid Surgery

NCT05805423
View directory record Official record
Conditions
Post Operative Pain, Nausea and Vomiting, Postoperative, Opioid Use
Interventions
bilateral superficial cervical plexus blocks and local wound infiltration, placebo injection and local wound infiltration
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 99 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 7, 2026, 4:17 PM EDT
Completed Not applicable Interventional Results available

The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer

NCT05132478
View directory record Official record
Conditions
Thyroid Cancer, Thyroid Nodule, Benign Thyroid Nodule
Interventions
Emotionally Supportive Video, Standard Video
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Sep 7, 2026, 4:17 PM EDT