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ClinicalTrials.gov public records Last synced Oct 7, 2026, 4:11 AM EDT

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Showing 217–240 of 940 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee Clear all
Recruiting Not applicable Interventional

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

NCT06617871
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy
Interventions
Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 79 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Supporting Decision Making for Musculoskeletal Preference-Sensitive Care

NCT01345123
View directory record Official record
Conditions
Knee Pain Chronic, Arthritis (Hip), Arthritis (Knee), Back Pain
Interventions
Provision of condition specific shared decision making (SDM) aids only, Telephonic outreach and support by Health Coach
Behavioral
Lead sponsor
Health Dialog
Industry
Eligibility
18 Years and older
Enrollment
9,925 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 30, 2013 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Static Progressive Splinting in the Management of Knee Stiffness Following Total Knee Arthroplasty

NCT04837872
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Multimodal Physical Therapy (MPT)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Golden, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Oct 7, 2026, 4:11 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty

NCT00409266
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Computer assisted navigation
Device
Lead sponsor
Stryker Instruments
Industry
Eligibility
18 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Plymouth, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 10, 2021 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

IPACK and Adductor Canal Catheter Patient Outcomes for TKAs?

NCT03774966
View directory record Official record
Conditions
Surgery, Acute Pain
Interventions
Adductor Canal Block + Catheter & IPACK block, Adductor canal block + catheter
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Phase 2 Interventional

Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain

NCT01415856
View directory record Official record
Conditions
Osteoarthritis
Interventions
Active Device (Torino II), Sham Device (Torino II)
Device
Lead sponsor
Center for Joint Surgery and Sports Medicine, Maryland
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2010
U.S. locations
1
States / cities
Hagerstown, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 12, 2011 · Synced Oct 7, 2026, 4:11 AM EDT
Recruiting No phase listed Observational

A Post-Market Domestic (US) and International Data Collection to Assess the Truliant Knee System

NCT05653102
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
Truliant Total Knee System
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2035
U.S. locations
5
States / cities
Aurora, Colorado • DeLand, Florida • Las Vegas, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2024 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Study of the Scandinavian Total Ankle Replacement (STAR) for the Treatment of Bilateral Degenerative Ankle Disease

NCT00586781
View directory record Official record
Conditions
Osteoarthritis, Post-Traumatic Arthritis, Rheumatoid Arthritis
Interventions
Scandinavian Total Ankle Replacement (STAR)
Device
Lead sponsor
Link America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
5
States / cities
Jacksonville, Florida • Iowa City, Iowa • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2008 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Not applicable Interventional

Are Adductor Canal Blocks With Bupivacaine and Added Magnesium Better at Managing Post-operative Pain Than Bupivacaine and Added Buprenorphine in Patients Undergoing Same-day Discharge Total Knee Arthroplasty?

NCT05091138
View directory record Official record
Conditions
Post-operative Pain, Acute, Opioid Use
Interventions
Adding Magnesium as an adjuvant to Bupivacaine in the adductor canal block (ACB) for same-day discharge total knee arthroplasty, Adding Buprenorphine as an adjuvant to Bupivacaine in the adductor canal block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study of the KinexConnect Telerehabilitation System (KCTRS)

NCT04191798
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
Behavioral
Lead sponsor
Kinex Medical Company, LLC
Industry
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 22, 2022 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Using a Smartphone App to Aid in Functional Mobility Return Following Total Knee Arthroplasty

NCT03607461
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Smartphone App, Control Group
Device · Combination Product
Lead sponsor
Lagniappe Physical Therapy
Other
Eligibility
45 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Inspired Helium for Ischemic Protection During Knee Replacement Surgery

NCT02012361
View directory record Official record
Conditions
Ischemia
Interventions
Control Group, Single-Dose Heliox Group, Muscle Biopsy
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Oct 7, 2026, 4:11 AM EDT
Terminated Phase 4 Interventional Results available

Combination of Peripheral Nerve Block and DepoDur in Total Knee Joint Replacement

NCT00895531
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Depodur, sciatic nerve block
Drug · Procedure
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Safety and Effectiveness of Resistance Exercise Training in Patients With Pompe Disease.

NCT02654886
View directory record Official record
Conditions
Pompe Disease, Muscle Weakness
Interventions
Resistance Exercise Training
Other
Lead sponsor
University of California, Irvine
Other
Eligibility
16 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 7, 2026, 4:11 AM EDT
Completed No phase listed Observational

A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf

NCT02251522
View directory record Official record
Conditions
Osteoarthritis
Interventions
ConforMIS Total Knee Replacement System, Off-the-Shelf Knee Replacement System
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
12
States / cities
Parker, Colorado • Fort Myers, Florida • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 7, 2026, 4:11 AM EDT
Completed No phase listed Observational

Multicenter Registry for Effectiveness Analysis of ActiveCare+S.F.T® Mobile Compression Device for Thrombosis Prevention in Hip and Knee Arthroplasty

NCT01984190
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
Not listed
Lead sponsor
Medical Compression Systems
Industry
Eligibility
18 Years and older
Enrollment
411 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
10
States / cities
Little Rock, Alaska • La Jolla, California • Menlo Park, California + 7 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Oct 7, 2026, 4:11 AM EDT
Withdrawn Phase 4 Interventional

Exparel vs Exparel Plus ACB in TKAs

NCT02365727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Liposomal bupivacaine, Ropivacaine, Epinephrine, Clonidine, Saline
Drug
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Study Evaluating the Safety, Efficacy and Pharmacokinetics of CA-008 (Vocacapsaicin)

NCT04203537
View directory record Official record
Conditions
Postsurgical Pain
Interventions
CA-008, Placebo
Drug
Lead sponsor
Concentric Analgesics
Industry
Eligibility
18 Years to 80 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
4
States / cities
Pasadena, California • Carrollton, Texas • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated May 8, 2024 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Effects of tDCS Combined With CBI on Postsurgical Pain

NCT04199780
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Interventions
Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 90 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training Following Total Knee Arthroplasty

NCT02763488
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
DelfiPTS tourniquet system, Standard physical therapy
Device · Other
Lead sponsor
San Antonio Military Medical Center
Federal
Eligibility
50 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 16, 2016 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Phase 4 Interventional

Dilute Betadine Lavage in the Prevention of Postoperative Infection

NCT01175044
View directory record Official record
Conditions
Prosthesis-Related Infections, Arthroplasty
Interventions
Betadine Lavage, Saline Lavage
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2021 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Exparel Use in Adductor Canal Block After Total Knee Arthroplasty

NCT04910165
View directory record Official record
Conditions
Arthritis Knee, Pain, Postoperative, Opioid Use
Interventions
Exparel, Ropivacaine
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2022 · Synced Oct 7, 2026, 4:11 AM EDT
Completed Not applicable Interventional

Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty

NCT01760863
View directory record Official record
Conditions
Prosthesis-Related Infections
Interventions
Oral Antibiotics
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
4
States / cities
Chicago, Illinois • Winfield, Illinois • Philadelphia, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Oct 7, 2026, 4:11 AM EDT
Not listed Not applicable Interventional

Long-Term Multicenter Evaluation of the E1® Tibial Bearing

NCT01374230
View directory record Official record
Conditions
Osteoarthritis of the Knee, Traumatic Arthritis of the Knee
Interventions
Total knee arthroplasty
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 75 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Oct 7, 2026, 4:11 AM EDT