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ClinicalTrials.gov public records Last synced Oct 12, 2026, 11:42 AM EDT

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Showing 361–384 of 941 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee Clear all
Terminated No phase listed Observational

Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting

NCT02820766
View directory record Official record
Conditions
Osteoarthritis, Degenerative Arthritis, Traumatic Arthritis
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
21 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Annapolis, Maryland • Eugene, Oregon • State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Study of the Scandinavian Total Ankle Replacement (STAR) for the Treatment of Bilateral Degenerative Ankle Disease

NCT00586781
View directory record Official record
Conditions
Osteoarthritis, Post-Traumatic Arthritis, Rheumatoid Arthritis
Interventions
Scandinavian Total Ankle Replacement (STAR)
Device
Lead sponsor
Link America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2001
U.S. locations
5
States / cities
Jacksonville, Florida • Iowa City, Iowa • Kansas City, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2008 · Synced Oct 12, 2026, 11:42 AM EDT
Recruiting No phase listed Observational

Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System

NCT06379321
View directory record Official record
Conditions
Knee Arthropathy, Recurrence, Knee Infection
Interventions
Triathlon Hinge Knee (THK) System
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
Not listed
Enrollment
200 participants
Timeline
2024 – 2034
U.S. locations
2
States / cities
Weston, Florida • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 12, 2026, 11:42 AM EDT
Completed No phase listed Observational Results available

Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty

NCT02276040
View directory record Official record
Conditions
Knee Pain Arthritis
Interventions
periarticular bupivicaine and liposomal bupivicaine
Drug
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
4
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2017 · Synced Oct 12, 2026, 11:42 AM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)

NCT04113785
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions
Klassic Knee System
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional Results available

A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events

NCT00736125
View directory record Official record
Conditions
Postoperative Complications, Memory Disorders
Interventions
pulsatile saline lavage, carbon dioxide lavage
Device
Lead sponsor
Kinamed Incorporated
Industry
Eligibility
50 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 12, 2026, 11:42 AM EDT
Recruiting No phase listed Observational

Post-Stroke Sensory Reweighting on Walking and Balance Outcomes

NCT06727097
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Posturography, Walking Speed, Instrumented 7M Timed UP and GO, Fall Event Records, MRI (3T)
Diagnostic Test · Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 12, 2026, 11:42 AM EDT
Completed No phase listed Observational

Postoperative Pain Management in Hospital and Following Discharge From Hospital.

NCT01907178
View directory record Official record
Conditions
Arthropathy of Knee Joint
Interventions
Not listed
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

NCT03838874
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Low-Dose Bupivacaine, Mepivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Days and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Oct 12, 2026, 11:42 AM EDT
Recruiting Phase 2 Interventional

The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis

NCT06911359
View directory record Official record
Conditions
Knee Osteoarthritis (OA)
Interventions
Participants are given Ibuprofen 400 mg to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times., Participants are given a placebo to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.
Drug
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Travis AFB, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional

Opioid Education in Total Knee Arthroplasty

NCT05593341
View directory record Official record
Conditions
Arthropathy of Knee, Post Operative Pain, Opioid Use, Opioid Abuse, Opioid Misuse
Interventions
Opioid education in person, Opioid education via video
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 12, 2026, 11:42 AM EDT
Recruiting Phase 4 Interventional

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

NCT06784882
View directory record Official record
Conditions
Acute Postoperative Pain, Surgery
Interventions
continuous peripheral nerve block with OnQ pump, single injection nerve block
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional Results available

Reducing Falls With RENEW in Older Adults Who Have Fallen

NCT01080196
View directory record Official record
Conditions
Muscle Atrophy, Physical Deconditioning
Interventions
RENEW
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
65 Years to 95 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional

Mindfulness Meditation Intervention Study

NCT06180486
View directory record Official record
Conditions
Total Knee Replacement, Mediation, Feasibility
Interventions
Mindfulness Meditation Intervention
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Inspired Helium for Ischemic Protection During Knee Replacement Surgery

NCT02012361
View directory record Official record
Conditions
Ischemia
Interventions
Control Group, Single-Dose Heliox Group, Muscle Biopsy
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 12, 2019 · Synced Oct 12, 2026, 11:42 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Daoist Zhanzhuang and Human Flourishing

NCT06573034
View directory record Official record
Conditions
Stress, Physiological, Stress, Psychological, Inflammatory Response, Well-Being, Psychological
Interventions
Daoist Zhanzhuang, Sham Wall Squat
Behavioral
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 25 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional

Amniotic Membrane in Total Knee Replacements to Reduce Scarring

NCT02088567
View directory record Official record
Conditions
Scarring
Interventions
Total Knee Arthroplasty, Application of dHACM
Procedure · Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2015 · Synced Oct 12, 2026, 11:42 AM EDT
Completed No phase listed Observational

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

NCT01398800
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Not listed
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
Not listed
Enrollment
340 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Oct 12, 2026, 11:42 AM EDT
Not listed No phase listed Observational

C3 Total Joint Patient Registry

NCT02188199
View directory record Official record
Conditions
Knee Replacement, Hip Replacement
Interventions
Not listed
Lead sponsor
DC2 Healthcare
Industry
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 11, 2014 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 4 Interventional Results available

Dexamethasone and Pain Following Total Knee Arthroplasty

NCT02271698
View directory record Official record
Conditions
Acute Pain, Chronic Pain
Interventions
Dexamethasone, Placebo
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
55 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 12, 2026, 11:42 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of Botulinum Toxin Injections in the Rectus Femoris to Treat Stiff Knee Gait Following Acquired Brain Injury

NCT00900666
View directory record Official record
Conditions
Stiff Knee Gait, Brain Injuries
Interventions
placebo, botulinum toxin A (BTX-A)
Drug
Lead sponsor
Mary Free Bed Rehabilitation Hospital
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2013 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Not applicable Interventional

Genicular Nerve Block for Knee Pain in the ED

NCT07158736
View directory record Official record
Conditions
Knee Pain
Interventions
Genicular nerve block with bupivacaine and corticosteroids, Standard of Care
Procedure · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 4 Interventional

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

NCT06291727
View directory record Official record
Conditions
Anesthesia, Spinal, Arthroplasty, Replacement, Knee
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 12, 2026, 11:42 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty

NCT00620828
View directory record Official record
Conditions
Osteoarthritis
Interventions
Placebo saline injection, Ropivicaine 0.5%
Other · Drug
Lead sponsor
Duke University
Other
Eligibility
Not listed
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2015 · Synced Oct 12, 2026, 11:42 AM EDT