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ClinicalTrials.gov public records Last synced Sep 30, 2026, 5:44 PM EDT

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Showing 25–48 of 940 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee Clear all
Terminated Not applicable Interventional

Manual Lymph Drainage

NCT02360735
View directory record Official record
Conditions
Total Knee Arthroplasty, Post-operative Edema
Interventions
Manual Lymphatic Drainage, Physical Therapy
Other
Lead sponsor
Anne Arundel Health System Research Institute
Other
Eligibility
45 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Annapolis, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 9, 2018 · Synced Sep 30, 2026, 5:44 PM EDT
Not listed Phase 4 Interventional

EXPAREL IPSA Block in Knee Arthroplasty

NCT06619340
View directory record Official record
Conditions
Pain, Postoperative, Osteo Arthritis Knee
Interventions
Exparel
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 30, 2026, 5:44 PM EDT
Completed No phase listed Observational

Impact of Component Design and Fixation in Total Knee Arthroplasty

NCT03272178
View directory record Official record
Conditions
Arthroplasties, Knee Replacement
Interventions
Depuy total knee implant, Triathlon total knee implant
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 1, 2021 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Not applicable Interventional Results available

iTotal Pilot Study of ConforMIS Custom Total Knee Implant

NCT02186587
View directory record Official record
Conditions
Knee Arthroplasty, Total
Interventions
ConforMIS custom total knee
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 23, 2023 · Synced Sep 30, 2026, 5:44 PM EDT
Enrolling by invitation No phase listed Observational

Genetic Markers of Patients With History of Pulmonary Embolism Post Total Joint Arthroplasty

NCT03275610
View directory record Official record
Conditions
Pulmonary Embolism
Interventions
Blood sample
Genetic
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2035
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Phase 4 Interventional Results available

Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)

NCT01780389
View directory record Official record
Conditions
Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain
Interventions
Open-label flexibly dosed milnacipran
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2015 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Not applicable Interventional Results available

Comparison of Three Surgical Techniques to Achieve Patella Symmetry During Resection

NCT01822574
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Injuries, Knee
Interventions
Cutting Guide Technique, Haptic Feedback Technique, Four Quadrant Technique
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Sep 30, 2026, 5:44 PM EDT
Completed No phase listed Observational

Evaluating Bactisure Wound Lavage in Orthopedic Wounds

NCT03192124
View directory record Official record
Conditions
Infection of Total Knee Joint Prosthesis
Interventions
Bactisure
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
5
States / cities
Los Angeles, California • Lexington, Kentucky • Louisville, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2020 · Synced Sep 30, 2026, 5:44 PM EDT
Recruiting Phase 2 Interventional

The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis

NCT06911359
View directory record Official record
Conditions
Knee Osteoarthritis (OA)
Interventions
Participants are given Ibuprofen 400 mg to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times., Participants are given a placebo to take for 7 days on the day they receive a dextrose prolotherapy (DPT) injection. These procedures are repeated every 3-5 weeks for a total of 3 times.
Drug
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years to 75 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Travis AFB, California
Source: ClinicalTrials.gov public record
Updated Nov 24, 2025 · Synced Sep 30, 2026, 5:44 PM EDT
Recruiting Not applicable Interventional

NT-II™ Collagen for Joint Discomfort and Function

NCT07119645
View directory record Official record
Conditions
Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain, Knee Acute and Chronic Pain
Interventions
NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
Dietary Supplement
Lead sponsor
Hofseth Biocare ASA
Industry
Eligibility
20 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Not applicable Interventional

Opioid Education in Total Knee Arthroplasty

NCT05593341
View directory record Official record
Conditions
Arthropathy of Knee, Post Operative Pain, Opioid Use, Opioid Abuse, Opioid Misuse
Interventions
Opioid education in person, Opioid education via video
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Phase 3 Interventional Results available

Study of Apixaban for the Prevention of Thrombosis-related Events Following Knee Replacement Surgery

NCT00371683
View directory record Official record
Conditions
Deep Vein Thrombosis, Pulmonary Embolism
Interventions
Enoxaparin + Placebo, Apixaban + Placebo
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years and older
Enrollment
3,608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
25
States / cities
Birmingham, Alabama • Tuscaloosa, Alabama • Little Rock, Arkansas + 17 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2015 · Synced Sep 30, 2026, 5:44 PM EDT
Terminated Not applicable Interventional Results available

Vitagel Revision Total Knee Arthroplasty

NCT01923805
View directory record Official record
Conditions
Failed Total Knee Arthroplasty
Interventions
Vitagel
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Intraarticular Antibiotic in TKA

NCT04297631
View directory record Official record
Conditions
Antibotics in Cementless Knees
Interventions
Tobramycin Powder, Vancomyscin
Drug · Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Phase 4 Interventional

Computer Assisted Total Knee Replacement

NCT00279838
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Computer Assisted Navigation Knee Replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 23, 2011 · Synced Sep 30, 2026, 5:44 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

MR Imaging of Knee Osteoarthritis and Acute Knee Injuries

NCT00504114
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
ACL Reconstruction Surgery, Cartilage Resurfacing Surgery, Total Knee Replacement
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2013 · Synced Sep 30, 2026, 5:44 PM EDT
Completed Not applicable Interventional Results available

Early Postoperative Compex Rehab NMES Use for Total Knee Arthroplasty Patients

NCT01844193
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Compex Rehab
Device
Lead sponsor
Orthopaedic Research Foundation
Other
Eligibility
45 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Greenwood, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Sep 30, 2026, 5:44 PM EDT
Not listed Not applicable Interventional

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

NCT04732962
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AposHealth, Total Knee Replacement (TKR)
Device · Procedure
Lead sponsor
Geisinger Clinic
Other
Eligibility
45 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 30, 2026, 5:44 PM EDT
Withdrawn Not applicable Interventional

Pain Control With Pre-operative Cryoneurolysis Following TKA

NCT03818022
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Cryoneurolysis (Iovera)
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 23, 2024 · Synced Sep 30, 2026, 5:44 PM EDT
Withdrawn No phase listed Observational

In Vivo Kinematics for Subjects Having a MicroPort Medial Pivot or DePuy Attune PCR TKA

NCT04103502
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Injuries, Knee Imlant
Interventions
MicroPort Medial Pivot TKA, DePuy Attune PCR TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
3
States / cities
Las Vegas, Nevada • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 30, 2026, 5:44 PM EDT
Active, not recruiting Not applicable Interventional

Persona Ti-Nidium Post-Market Clinical Follow-up

NCT04817969
View directory record Official record
Conditions
Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis
Interventions
Zimmer Biomet Persona Ti-Nidium Total Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2034
U.S. locations
7
States / cities
Parker, Colorado • Hyattsville, Maryland • Jackson, Mississippi + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Sep 30, 2026, 5:44 PM EDT
Recruiting Phase 2 Interventional

A Study on TLC590 for Managing Postsurgical Pain

NCT06574269
View directory record Official record
Conditions
Postsurgical Pain Management
Interventions
TLC590, Ropivacaine
Drug
Lead sponsor
TLC Biopharmaceuticals, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Bellaire, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 30, 2026, 5:44 PM EDT
Not listed Phase 1 Interventional

Electrical Stimulation After Total Knee Arthroplasty

NCT00224913
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
Neuromuscular electrical stimulation, Voluntary exercise
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
45 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 12, 2005 · Synced Sep 30, 2026, 5:44 PM EDT