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ClinicalTrials.gov public records Last synced Oct 14, 2026, 9:52 AM EDT

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Showing 745–768 of 942 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee Clear all
Completed Phase 1 Interventional Results available

Melatonin Use After Primary Total Joint Arthroplasty

NCT04795336
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Melatonin 5 mg, Placebo
Drug · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 95 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2025 · Synced Oct 14, 2026, 9:52 AM EDT
Not listed Not applicable Interventional

Post-Market Study of Robotic-Arm Assisted Total Knee Arthroplasty

NCT03106558
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total Knee Arthroplasty using Manual Instrumentation, Total Knee Arthroplasty using Robotic Arm
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Athens, Georgia • Egg Harbor, New Jersey • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Phase 4 Interventional

Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial

NCT03283878
View directory record Official record
Conditions
Arthropathy of Knee, Antibiotic Prophylaxis
Interventions
Cefazolin
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,770 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
14
States / cities
San Francisco, California • Atlanta, Georgia • Towson, Maryland + 11 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 14, 2026, 9:52 AM EDT
Active, not recruiting Phase 4 Interventional Accepts healthy volunteers

Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)

NCT04082533
View directory record Official record
Conditions
Pain, Arthrofibrosis, Osteoarthritis, Knee
Interventions
Hydrocortisone, Dextrose 5% in water (D5W)
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 83 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Not applicable Interventional

Addressing Patients' Expectations of Total Knee Arthroplasty in a Randomized Trial

NCT00197977
View directory record Official record
Conditions
Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Interventions
Educational program to address patients' expectations
Behavioral
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
40 Years and older
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 23, 2011 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Not applicable Interventional Results available

Triathlon® Posteriorly Stabilized (PS) Total Knee System - Outcomes Study

NCT00957021
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon® PS Total Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 80 Years
Enrollment
409 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
11
States / cities
Columbus, Georgia • Indianapolis, Indiana • Boston, Massachusetts + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced Oct 14, 2026, 9:52 AM EDT
Active, not recruiting Not applicable Interventional

Analysis of Varus Collapse in Obese Patients With Stem and Non-Stem Tibial Components Following Primary Total Knee Arthroplasty

NCT06019832
View directory record Official record
Conditions
Obesity, Aseptic Loosening, Varus Collapse
Interventions
Total Knee Arthroplasty (TKA), Stemmed Tibial Implant, Non-stemmed tibial implant
Procedure · Device
Lead sponsor
Jacob M. Elkins
Other
Eligibility
40 Years to 99 Years · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
1
States / cities
North Liberty, Iowa
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 14, 2026, 9:52 AM EDT
Completed No phase listed Observational

Prediction of Outcomes Following Total Knee Replacement

NCT01370421
View directory record Official record
Conditions
Osteoarthritis
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 14, 2026, 9:52 AM EDT
Withdrawn Phase 4 Interventional

Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty

NCT05157464
View directory record Official record
Conditions
Arthrofibrosis
Interventions
Losartan
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 14, 2026, 9:52 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions

NCT02335710
View directory record Official record
Conditions
Knee Injuries
Interventions
Journey II BCS TKA
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
40 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
3
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Oct 14, 2026, 9:52 AM EDT
Withdrawn Not applicable Interventional

To Determine the Gait and Functional Improvement in Total Knee Arthroplasty

NCT04057885
View directory record Official record
Conditions
Degenerative Arthritis
Interventions
Orthosensor™ VERASENSE™ Knee System
Device
Lead sponsor
LifeBridge Health
Other
Eligibility
45 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2020 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty

NCT03051984
View directory record Official record
Conditions
Knee Osteoarthristis
Interventions
Neuromuscular electrical stimulation
Device
Lead sponsor
University of Vermont
Other
Eligibility
50 Years to 75 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Phase 3 Interventional Results available

Efficacy, Safety, and Pharmacokinetics of Femoral Nerve Block With EXPAREL in Total Knee Arthroplasty

NCT02713178
View directory record Official record
Conditions
Pain
Interventions
bupivacaine liposome injectable suspension, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
14
States / cities
Mobile, Alabama • Englewood, Colorado • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2020 · Synced Oct 14, 2026, 9:52 AM EDT
Recruiting Phase 1Phase 2 Interventional

Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)

NCT06640491
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin, IV Administration of Vancomycin
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2025 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Not applicable Interventional

Effects of tDCS Combined With CBI on Postsurgical Pain

NCT04199780
View directory record Official record
Conditions
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty (Postoperative Pain)
Interventions
Transcranial Direct Current Stimulation, Cognitive-Behavioral (CB) intervention
Device · Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 90 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Oct 14, 2026, 9:52 AM EDT
Terminated No phase listed Observational

Evaluation of the VEGA Knee System® Range of Motion

NCT01768871
View directory record Official record
Conditions
Patients With Total Knee Arthroplasty Using the VEGA System
Interventions
Not listed
Lead sponsor
Aesculap Implant Systems
Industry
Eligibility
21 Years to 75 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Denver, Colorado • Vero Beach, Florida • Asheville, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Phase 3 Interventional

Acupuncture for Post-Thoracotomy Pain

NCT00142532
View directory record Official record
Conditions
Lung Cancer, Pain
Interventions
Acupuncture and Questionnaires, Placebo Acupuncture, Questionnaires
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2009 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Not applicable Interventional

Amniotic Membrane in Total Knee Replacements to Reduce Scarring

NCT02088567
View directory record Official record
Conditions
Scarring
Interventions
Total Knee Arthroplasty, Application of dHACM
Procedure · Other
Lead sponsor
MiMedx Group, Inc.
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 23, 2015 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Early Phase 1 Interventional

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

NCT02740192
View directory record Official record
Conditions
Pain
Interventions
Adductor Canal Block, Periarticular Injection, Ropivacaine, Bupivacaine
Procedure · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Regional Prophylactic Vancomycin in Revision Total Knee Replacement

NCT02020031
View directory record Official record
Conditions
Arthropathy of Knee Joint
Interventions
Vancomycin
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 25, 2016 · Synced Oct 14, 2026, 9:52 AM EDT
Terminated Not applicable Interventional

Primary TKA Cruciate Retaining vs Cruciate Substituting With Rotating Platform Knee Prostheses

NCT00289081
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Rheumatoid, Avascular Necrosis of Bone, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
399 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
4
States / cities
La Jolla, California • Crystal River, Florida • Melbourne, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated May 13, 2014 · Synced Oct 14, 2026, 9:52 AM EDT
Withdrawn Phase 4 Interventional

Liposomal Bupivacaine in Total Knee Arthroplasty

NCT02426164
View directory record Official record
Conditions
Pain, Postoperative, Arthroplasty, Replacement, Knee, Osteoarthritis
Interventions
Liposomal bupivacaine, bupivacaine HCl, morphine, epinephrine, methylprednisolone
Drug
Lead sponsor
Miller Orthopedic Specialists
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Council Bluffs, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 22, 2016 · Synced Oct 14, 2026, 9:52 AM EDT
Completed No phase listed Observational Results available

Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement

NCT01320150
View directory record Official record
Conditions
Persistent Postsurgical Pain
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
311 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 23, 2021 · Synced Oct 14, 2026, 9:52 AM EDT
Completed Phase 4 Interventional Results available

Management of Postoperative Pain After Total Knee Replacement.

NCT01163214
View directory record Official record
Conditions
Postoperative Pain, Knee Replacement Arthroplasty
Interventions
Nerve Block, Periarticular Injection
Drug
Lead sponsor
Mark J. Spangehl, M.D.
Other
Eligibility
18 Years to 79 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 5, 2014 · Synced Oct 14, 2026, 9:52 AM EDT