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ClinicalTrials.gov public records Last synced Oct 15, 2026, 10:25 PM EDT

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Showing 841–864 of 942 matching trials from the live ClinicalTrials.gov search.
Conditions
Knee Arthritis
Interventions
manually instrumented total knee arthroplasty, robotic assisted total knee arthroplasty
Procedure · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
25 Years to 95 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Conditions
Anterior Cruciate Ligament Reconstruction, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Hip Arthroscopy
Interventions
Visualization training with neurofeedback, Standard post-surgical rehabilitation therapy
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Total Knee Arthroplasty
Interventions
IO Administration of Cefazolin, IO Administration of Vancomycin, IV Administration of Cefazolin, IV Administration of Vancomycin
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2035
U.S. locations
1
States / cities
Houston, Texas
Completed Not applicable Interventional Results available

Digital Knee Osteoarthritis Mindset Intervention

NCT05698368
Conditions
Knee Osteoarthritis
Interventions
Mindset intervention, Active comparator
Behavioral · Other
Lead sponsor
Stanford University
Other
Eligibility
45 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Stanford, California
Not listed No phase listed Observational

Knee Arthroplasty Registry

NCT01132365
Conditions
Osteoarthritis, Knee
Interventions
any knee joint arthroplasty device
Device
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 93 Years
Enrollment
7,793 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Conditions
Arthroplasty, Replacement, Knee
Interventions
CORI Robotics
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Morrisville, North Carolina • New Albany, Ohio + 1 more
Completed No phase listed Observational

10003 PRO Current Products

NCT01497730
Conditions
Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
11
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 8 more
Conditions
Osteoarthritis (OA) of the Knee
Interventions
CT scan unilateral knee, CT scan bilateral knee
Diagnostic Test
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Louisville, Kentucky
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions
Klassic Knee System
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Surgical and Economical Parameters of Total Knee Replacement.

NCT03427047
Conditions
Osteo Arthritis Knee, Total Knee Arthroplasty
Interventions
MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
16 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Conditions
Stiffness Following Total Knee Arthroplasty
Interventions
Dexamethasone, Celecoxib
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
16
States / cities
Little Rock, Arkansas • Denver, Colorado • Chicago, Illinois + 11 more
Conditions
Knee Injuries
Interventions
Blood Flow Restriction, Standard rehabilitation
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
West Point, New York • Fort Bragg, North Carolina
Terminated Phase 4 Interventional Results available

US Guided GNB vs Saline Injection for TKA

NCT03316118
Conditions
Postoperative Pain, Total Knee Arthroplasty, Nerve Block
Interventions
bupivacaine, saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
40 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Trigger Point Pain, Myofascial
Interventions
Trigger point injection (lidocaine), Sham Comparator
Drug · Other
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, California
Conditions
Pain, Total Knee Arthroplasty
Interventions
Dexamethasone, Ropivacaine
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Albuquerque, New Mexico
Conditions
Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions
Duracon®, Vanguard™
Device
Lead sponsor
Biomet Orthopedics, LLC
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Warsaw, Indiana
Completed Not applicable Interventional Results available

Stability of the Medial Pivot Total Knee Prosthesis

NCT02577978
Conditions
Osteoarthritis of Knee
Interventions
Medacta GMK posterior stabilized prosthesis, Medacta GMK Sphere prosthesis
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 85 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Conditions
Osteoarthritis of the Knee
Interventions
Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery
Procedure
Lead sponsor
Foundation for Southwest Orthopedic Research
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Houston, Texas
Conditions
Diabetic Foot Ulcer, Diabetes Mellitus, Foot Ulcer, Foot Ulcer, Diabetic, Ulcer, Ulcer Foot, Ulcer, Leg, Ankle Ulcer
Interventions
Total Contact Soft Cast, Cam Boot
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Conditions
Bone Sarcoma, Osteosarcoma, Chondrosarcoma, Ewing's Sarcoma, Osseous Sarcoma, Bone Neoplasm
Interventions
Toronto Extremity Salvage Score, Musculoskeletal Tumor Society Score, Timed Get Up and Go Test, Orthogonal Radiographs, Weight Bearing for lower extremities only, Range of Motion
Behavioral · Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
4 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
5
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Harrison, New York + 2 more
Terminated Not applicable Interventional

Health Partner Evaluation at Princeton

NCT03386786
Conditions
Total Knee Arthroplasty; Total Hip Arthroplasty
Interventions
Health Partner, Standard Care
Behavioral
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Plainsboro, New Jersey
Conditions
Opioid Use, Arthropathy of Knee, Pain, Postoperative
Interventions
RelieVRx headset, multi-modality pain management
Device · Drug
Lead sponsor
AppliedVR Inc.
Industry
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania