Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 6, 2026, 12:51 AM EST

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Showing 1–24 of 853 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Total knee arthroplasty Clear all

Conditions: Osteoarthritis, Postoperative Pain
Interventions: Whole blood for genotyping; Genetic
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Total Knee Replacement
Interventions: hand mixed vancomycin, hand mixed tobramycin, pre-mixed tobramycin; Drug · Device
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Total Knee Arthroplasty
Interventions: DepoTXA, Tranexamic Acid; Drug
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 5
States / cities: Gilbert, Arizona • Miami, Florida • Columbus, Ohio + 1 more

Conditions: Osteoarthritis
Interventions: Visionaire system (Knee MRI), No Knee MRI; Other
Lead sponsor: The Hawkins Foundation; Other
Eligibility: 18 Years to 100 Years
Enrollment: 149 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Greenville, South Carolina

Conditions: Arthroplasty, Replacement, Knee
Interventions: Not listed
Lead sponsor: Colorado Joint Replacement; Other
Eligibility: Not listed
Enrollment: 340 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Osteoarthritis
Interventions: Total knee; Procedure
Lead sponsor: Heekin Orthopedic Research Institute; Other
Eligibility: 21 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Osteo Arthritis Knee
Interventions: Unicompartmental knee arthroplasty, Total knee arthroplasty; Procedure
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: 18 Years to 75 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 2
States / cities: Chicago, Illinois • Alexandria, Virginia

Conditions: Osteoarthritis
Interventions: Topical Tranexamic Acid, Intravenous Tranexamic Acid; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 100 Years
Enrollment: 640 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 2
States / cities: Rochester, Minnesota • New York, New York

Conditions: Total Knee Arthroplasty, Osteoarthritis
Interventions: Physical Activity Behavior Intervention, Attention Control; Behavioral · Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 85 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions: POPOP (preoperative patient optimization program), SOC (standard of care); Other
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years to 80 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Knee Arthritis, Knee Osteoarthritis
Interventions: Suzetrigine; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 95 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 3
States / cities: Atlanta, Georgia

Conditions: Knee Pain After Total Knee Arthroplasty, Osteoarthritis Pain
Interventions: Open-label flexibly dosed milnacipran; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Osteo Arthritis Knee
Interventions: Isotonic saline, Ketamine Injectable Solution; Drug
Lead sponsor: Rothman Institute Orthopaedics; Other
Eligibility: Not listed
Enrollment: 75 participants
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Arthritis of the Knee
Interventions: iovera°, iovera° Sham; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 22 Years to 79 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 8
States / cities: San Diego, California • Englewood, Colorado • Fort Lauderdale, Florida + 5 more

Conditions: Anemia, Arthritis, Total Knee Arthroplasty, Total Hip Arthroplasty
Interventions: Conventional Oral TXA (Tranexamic Acid), Multi-Dose Oral TXA (Tranexamic Acid); Drug
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Postoperative Recovery
Interventions: GRF6021, Placebo; Biological · Other
Lead sponsor: Alkahest, Inc.; Industry
Eligibility: 50 Years to 85 Years
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Osteoarthritis, Pain, Postoperative
Interventions: Liposomal bupivacaine, Bupivacaine plus dexamethasone; Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 40 Years to 70 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Albany, New York

Conditions: Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
Interventions: Tryptase, Serum test; Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 20 Years to 100 Years
Enrollment: 219 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Pain, Osteoarthritis
Interventions: Canal Block and Capsular Injection, Femoral with Tibial Nerve Block; Procedure
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 80 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Knee Osteoarthritis, Knee Arthropathy
Interventions: Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 21 Years to 79 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Total Knee Arthroplasty, Knee Pain
Interventions: 0.1% and 0.4% perineural ropivicaine; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Degenerative Joint Disease
Interventions: Sigma Knee System, Sigma Pressfit Condylar Posterior Cruciate Substituting System with a metal back tibial tray, Sigma Pressfit Condylar Posterior Cruciate Substituting System all polyethylene tray; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 40 Years to 75 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2011
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions: Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus; Procedure
Lead sponsor: West Virginia University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Morgantown, West Virginia

Conditions: Arthroplasty, Replacement, Knee
Interventions: Pre Operative Oral Fluids; Other
Lead sponsor: Colorado Joint Replacement; Other
Eligibility: 18 Years to 75 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: Denver, Colorado

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Acute Pain Genomic Study

Antibiotic Elution in Total Knee Arthroplasty

Study of Local Administration of DepoTXA for Reduced Postsurgical Bleeding in Subjects Undergoing TKA

Visionaire: A Prospective Study

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty

Trial of Unicompartmental Versus Total Knee Arthroplasty

Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical

Optimizing Physical Activity Outcomes After Total Knee Arthroplasty

Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty

Open-label Milnacipran for Persistent Knee Pain One Year After Total Knee Arthroplasty (TKA)

Post-op Ketamine Study

A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty

Single Versus Multi-Dose Oral Tranexamic Acid in Patients at High Risk for Blood Transfusion After Total Joint Arthroplasty

A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty

Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty

A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients

Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

Optimizing Local Anesthetic Concentration for Continuous Femoral Nerve Blocks

Comparison of A Mobile-Bearing Total Knee System With A Fixed-Bearing Total Knee System In Cemented Total Knee Arthroplasty

Rate of Allergic Contact Dermatitis and Cosmetic Outcomes

Traditional vs Oral Fluid Management in Total Knee Arthroplasty