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ClinicalTrials.gov public records Last synced Oct 14, 2026, 9:51 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 433–456 of 475 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee arthroplasty patients Clear all
Completed Not applicable Interventional

Resiliency in Total Joint Arthroplasty

NCT04357262
View directory record Official record
Conditions
Osteoarthritis
Interventions
StreaMD
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 15, 2022 · Synced Oct 14, 2026, 9:51 PM EDT
Not yet recruiting Not applicable Interventional

Knee Positioning After Total Knee Replacement

NCT07747116
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Knee Flexion, Standard Care
Other · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Not applicable Interventional Results available

Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation

NCT04269239
View directory record Official record
Conditions
Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Healthy Habits, Sleep Habits
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
40 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Galveston, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Completed No phase listed Observational

Study of Patient Outcomes 5 Years After Partial Knee Replacement

NCT01620892
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
Athens Orthopedic Clinic, P.A.
Other
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 10, 2019 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Not applicable Interventional

Regenexx™ SD Versus Exercise Therapy for Treatment of Knee Osteoarthritis With Historical Comparison to TKA

NCT02034032
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Regenexx SD, Exercise Therapy
Procedure · Behavioral
Lead sponsor
Regenexx, LLC
Industry
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Des Plaines, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 4, 2019 · Synced Oct 14, 2026, 9:51 PM EDT
Active, not recruiting Not applicable Interventional

Survivorship of Attune Primary Total Knee Prosthesis

NCT01754363
View directory record Official record
Conditions
Noninflammatory Degenerative Joint Disease
Interventions
Attune Primary Total Knee Replacement
Device
Lead sponsor
DePuy International
Industry
Eligibility
22 Years to 75 Years
Enrollment
1,542 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2030
U.S. locations
9
States / cities
Scottsdale, Arizona • Orange, California • DeLand, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Not applicable Interventional

Three Different Approaches for Ultrasound Guided Femoral Nerve Block for Patients Undergoing Total Knee Arthroplasty

NCT01763814
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Femoral nerve block, Femoral nerve block non stimulating catheter, Femoral nerve block stimulating catheter
Procedure
Lead sponsor
Chicago Anesthesia Pain Specialists
Other
Eligibility
18 Years to 90 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 7, 2019 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Phase 4 Interventional Results available

Dexamethasone and Pain Following Total Knee Arthroplasty

NCT02271698
View directory record Official record
Conditions
Acute Pain, Chronic Pain
Interventions
Dexamethasone, Placebo
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
55 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 14, 2026, 9:51 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Continuous Femoral and Tibial Nerve Blocks in TKA Patients

NCT01680692
View directory record Official record
Conditions
Analgesia in Total Knee Arthroplasty
Interventions
Ropivicaine, Continuous Femoral Nerve Catheter, Continuous Tibial Nerve Catheter
Drug · Device
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Oct 14, 2026, 9:51 PM EDT
Completed No phase listed Observational

Novel Strategies for Personalized Clinical Decisions in Knee Arthroplasty

NCT05900453
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Clinical decision support (CDS) tool
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
40 Years and older
Enrollment
675 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Oct 14, 2026, 9:51 PM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 14, 2026, 9:51 PM EDT
Active, not recruiting No phase listed Observational

A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory Arthritis

NCT05197036
View directory record Official record
Conditions
Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2033
U.S. locations
12
States / cities
Atlanta, Georgia • Boston, Massachusetts • Novi, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Duloxetine RCT on Postop TKA Outcomes

NCT05086393
View directory record Official record
Conditions
Pain, Postoperative, Total Knee Arthroplasty
Interventions
Duloxetine, Placebos
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 14, 2025 · Synced Oct 14, 2026, 9:51 PM EDT
Not listed No phase listed Observational

Knee Arthroplasty Registry

NCT01132365
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
any knee joint arthroplasty device
Device
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 93 Years
Enrollment
7,793 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 26, 2016 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Not applicable Interventional Results available

Nurse Initiated Acupressure for Pain Management

NCT04044716
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute
Interventions
Auricular acupressure, Standard of care pain management
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bermuda Run, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Phase 2 Interventional

Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty

NCT06716749
View directory record Official record
Conditions
Primary Total Knee Arthroplasty, Intraosseous Morphine Injection, Knee Osteoarthritis
Interventions
Morphine, Vancomycin
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Oct 14, 2026, 9:51 PM EDT
Recruiting Not applicable Interventional

Hinge vs CCK Implants

NCT07818343
View directory record Official record
Conditions
Revision Arthroplasty, Knee
Interventions
Condylar Constrained knee system. ( NexGen Legacy Condylar Constrained Knee by Zimmer Biomet), Rotating Hinge Knee ( NexGen Rotating Hinge Knee by Zimmer Biomet)
Device
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2037
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Olney, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Ipack Block and Surgeon's Joint Infiltration in Total Knee Arthroplasty

NCT03653416
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Ipack, Bupivacaine, Peri Articular Infiltration
Device · Drug · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 14, 2026, 9:51 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

NCT04146649
View directory record Official record
Conditions
Effusion Joint
Interventions
Arthrocentesis
Procedure
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 31, 2023 · Synced Oct 14, 2026, 9:51 PM EDT
Completed Not applicable Interventional

Telemedicine in Total Hip Arthroplasty and Total Knee Arthroplasty

NCT03961711
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Telemedicine, In-Person Clinic Visit
Procedure
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 4, 2020 · Synced Oct 14, 2026, 9:51 PM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Oct 14, 2026, 9:51 PM EDT
Recruiting Not applicable Interventional

Stiffness and Low Dose Irradiation RCT

NCT07767097
View directory record Official record
Conditions
Arthrofibrosis of Knee
Interventions
Low-Dose External Beam Irradiation, Hinged Revision Total Knee Arthroplasty
Radiation · Procedure
Lead sponsor
Mount Sinai Hospital, Canada
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Los Angeles, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 14, 2026, 9:51 PM EDT
Terminated No phase listed Observational

TKA Operating Room Efficiency for TKA Using Customized Implant Techniques

NCT04180423
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Off-the-Shelf Implant Total Knee Replacement, Customized Implant Total Knee Replacement
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
59 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Kettering, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 14, 2026, 9:51 PM EDT
Completed No phase listed Observational

Stated-Preferences in Knee Arthroplasty

NCT03058380
View directory record Official record
Conditions
Arthritis, Knee Osteoarthritis, Arthropathy of Knee
Interventions
Stated-Preferences Evaluation Instrument
Other
Lead sponsor
Duke University
Other
Eligibility
40 Years to 80 Years
Enrollment
348 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 14, 2026, 9:51 PM EDT