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ClinicalTrials.gov public records Last synced Oct 9, 2026, 6:46 AM EDT

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Showing 49–72 of 475 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Total knee arthroplasty patients Clear all
Completed No phase listed Observational

A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS

NCT03152357
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Osteoarthritis
Interventions
ConforMIS iUni, iDuo, or iTotal (CR)
Device
Lead sponsor
Restor3D
Industry
Eligibility
18 Years and older
Enrollment
950 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 9, 2026, 6:46 AM EDT
Enrolling by invitation Not applicable Interventional

Rate of Allergic Contact Dermatitis and Cosmetic Outcomes

NCT06957444
View directory record Official record
Conditions
Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty

NCT02166632
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Intracapsular Injection, Periarticular Injection
Procedure
Lead sponsor
Broward Health
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 10, 2016 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)

NCT02223364
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

NCT02638623
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lactated Ringer, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 9, 2026, 6:46 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Peanut Protein Supplementation to Prevent Muscle Atrophy and Improve Recovery Following Total Knee Arthroplasty

NCT04294563
View directory record Official record
Conditions
Surgery
Interventions
Peanut Protein Powder, Standard Care by Surgeon and Physical Therapist
Dietary Supplement · Other
Lead sponsor
Auburn University
Other
Eligibility
60 Years to 75 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Impact of Prehabilitation in Total Knee Replacement

NCT01844934
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Prehabilitation
Other
Lead sponsor
Allina Health System
Other
Eligibility
Not listed
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Fridley, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 9, 2026, 6:46 AM EDT
Withdrawn No phase listed Observational

Preop Cooled Radiofrequency Ablation for Total Knee Replacement

NCT03893292
View directory record Official record
Conditions
Postoperative Pain, Knee Osteoarthritis
Interventions
Total knee replacement, COOLIEF
Procedure · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Phase 4 Interventional Results available

Apixaban Pharmacokinetics in Bariatric Patients (APB)

NCT02406885
View directory record Official record
Conditions
Bariatric Surgery, Obesity
Interventions
Apixaban
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Post-operative Pain Relief and Decrease Opioid Consumption: a Prospective Randomized Controlled Trial

NCT05004636
View directory record Official record
Conditions
Post-operative Pain, Acute
Interventions
Adding Magnesium as an adjuvant to the adductor canal Block (ACB) for same-day discharge total knee arthroplasty
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 100 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Pontiac, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 9, 2026, 6:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Zip Arthroplasty Patient Satisfaction Evaluation

NCT03178266
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Knee Arthroplasty
Device
Lead sponsor
ZipLine Medical Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Norristown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Oct 9, 2026, 6:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Biopsychosocial Impact on Caregivers in Patients Undergoing Joint and Spine Surgery

NCT03059602
View directory record Official record
Conditions
Pain, Postoperative
Interventions
No specific treatment based intervention-health measurement instrument
Other
Lead sponsor
Defense and Veterans Center for Integrative Pain Management
Other
Eligibility
18 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Oct 9, 2026, 6:46 AM EDT
Not listed No phase listed Observational

Survivorship and Outcomes of Robotically Assisted Patellofemoral UKA

NCT01947686
View directory record Official record
Conditions
Patellofemoral Knee Arthroplasty
Interventions
Robotically guided patellofemoral UKA isolated patellofemoral implants
Device
Lead sponsor
St. Helena Hospital Coon Joint Replacement Institute
Other
Eligibility
21 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
2
States / cities
St. Helena, California • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Mindfulness Meditation Intervention Study

NCT06180486
View directory record Official record
Conditions
Total Knee Replacement, Mediation, Feasibility
Interventions
Mindfulness Meditation Intervention
Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional Results available

A Study to Compare the NexGen LPS and LPS-Flex Knee Implants

NCT00763386
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteoarthritis
Interventions
NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 80 Years
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2010
U.S. locations
14
States / cities
Birmingham, Alabama • Decatur, Georgia • Springfield, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2012 · Synced Oct 9, 2026, 6:46 AM EDT
Not yet recruiting Not applicable Interventional

Knee Positioning After Total Knee Replacement

NCT07747116
View directory record Official record
Conditions
Knee Arthroplasty
Interventions
Knee Flexion, Standard Care
Other · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Enrolling by invitation Phase 4 Interventional

Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery

NCT07584915
View directory record Official record
Conditions
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Interventions
Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block), Bupivacaine liposome injectable suspension (LIA)
Procedure · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Completed No phase listed Observational

Intra-articular Volumetric Assessment After Total Knee Arthroplasty

NCT02821325
View directory record Official record
Conditions
Hematoma
Interventions
MRI
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 89 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Phase 4 Interventional

Systemic Lidocaine Versus Ultrasound-guided Adductor Canal Block for Patients Undergoing Total Knee Arthroplasty

NCT04828083
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Total Knee Arthroplasty
Interventions
Lidocaine IV, Saline IV
Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic Consumption

NCT03534102
View directory record Official record
Conditions
Opioid Use, Opioid Dependence, Knee Pain Chronic, Knee Osteoarthritis
Interventions
Improved Opioid-Tapering Instructions, Clinical Patient Educator
Drug · Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 27, 2023 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional Results available

Acute Pain Genomic Study

NCT01557751
View directory record Official record
Conditions
Osteoarthritis, Postoperative Pain
Interventions
Whole blood for genotyping
Genetic
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 12, 2023 · Synced Oct 9, 2026, 6:46 AM EDT
Completed Not applicable Interventional

Thigh Pain After Total Knee Arthroplasty (TKA)

NCT02262988
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total knee replacement
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 9, 2026, 6:46 AM EDT
Not yet recruiting Not applicable Interventional

NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty

NCT07439666
View directory record Official record
Conditions
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
Interventions
NEUROCUPLE™ Patch, Sham patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
Device · Other
Lead sponsor
Jacques E. Chelly
Other
Eligibility
18 Years and older
Enrollment
274 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 9, 2026, 6:46 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Using a Smartphone App to Aid in Functional Mobility Return Following Total Knee Arthroplasty

NCT03607461
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Smartphone App, Control Group
Device · Combination Product
Lead sponsor
Lagniappe Physical Therapy
Other
Eligibility
45 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 9, 2026, 6:46 AM EDT