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ClinicalTrials.gov public records Last synced Oct 30, 2026, 7:20 PM EDT

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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Traditional Total Knee Replacement Clear all
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty

NCT03133481
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
Adductor Canal Nerve Block, Femoral Nerve Block
Procedure · Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Phase 4 Interventional Results available

Knee Arthroplasty Performed With Conventional and Customized Instrumentation

NCT01124305
View directory record Official record
Conditions
Knee Arthritis
Interventions
Customized Patient Instrumentation, Traditional Instrumentation
Device
Lead sponsor
Anderson Orthopaedic Research Institute
Other
Eligibility
Not listed
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Alexandria, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 18, 2013 · Synced Oct 30, 2026, 7:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study of the KinexConnect Telerehabilitation System (KCTRS)

NCT04191798
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
Behavioral
Lead sponsor
Kinex Medical Company, LLC
Industry
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Des Moines, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 22, 2022 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional Results available

Virtual vs. Traditional Physical Therapy Following Total Knee Replacement

NCT02914210
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Virtual physical therapy rehabilitation program, No intervention
Device · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
306 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Greensboro, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2021 · Synced Oct 30, 2026, 7:20 PM EDT
Terminated Not applicable Interventional

Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty

NCT06617338
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
CT scan unilateral knee, CT scan bilateral knee
Diagnostic Test
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 30, 2026, 7:20 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Prospective Study to Evaluate Robot Assisted Total Knee Replacement Outcomes

NCT03523897
View directory record Official record
Conditions
Primary Osteoarthritis of Knee Nos
Interventions
Robot Assisted Total Knee Replacement, Traditional Total Knee Replacement
Procedure
Lead sponsor
Virtua Health, Inc.
Other
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional

Minimally Invasive Surgical Approaches In Total Knee Arthroplasty

NCT01461356
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Minimally invasive total knee replacement, Standard approach total knee replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 28, 2011 · Synced Oct 30, 2026, 7:20 PM EDT
Not listed Not applicable Interventional

Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement

NCT04732962
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
AposHealth, Total Knee Replacement (TKR)
Device · Procedure
Lead sponsor
Geisinger Clinic
Other
Eligibility
45 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Danville, Pennsylvania • Wilkes-Barre, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Oct 30, 2026, 7:20 PM EDT
Not listed No phase listed Observational

Intraoperative Soft Tissue Balance in TKA

NCT05006274
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Persona Trabecular Metal Tibia, Verasense technology, MUVR
Device
Lead sponsor
Washington Hospital Healthcare System
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Fremont, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Traditional vs Oral Fluid Management in Total Knee Arthroplasty

NCT03719378
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Pre Operative Oral Fluids
Other
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Oct 30, 2026, 7:20 PM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional

Pain Neuroscience Education in Total Knee Arthroplasty

NCT03231566
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 27, 2017 · Synced Oct 30, 2026, 7:20 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analysis of Standard Versus Barbed Sutures in Primary Total Knee Arthroplasty.

NCT01320371
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 80 Years
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
4
States / cities
Durham, North Carolina • New Albany, Ohio • Temple, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2014 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Medacta GMK Sphere® Multicenter Post-Market Outcomes Study

NCT02501733
View directory record Official record
Conditions
Osteoarthritis
Interventions
Medacta GMK Sphere® Medial Knee Prosthesis
Device
Lead sponsor
Medacta USA
Industry
Eligibility
21 Years to 80 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
5
States / cities
Chicago, Illinois • New Orleans, Louisiana • Oklahoma City, Oklahoma + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 30, 2026, 7:20 PM EDT
Withdrawn Not applicable Interventional

Comparison of Implant Positioning With Robotic Aided Surgery and Traditional Jig Positioning in Total Knee Arthroplasty

NCT03052790
View directory record Official record
Conditions
Knee Arthritis
Interventions
manually instrumented total knee arthroplasty, robotic assisted total knee arthroplasty
Procedure · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
25 Years to 95 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional

A Randomized Prospective Trial of Total Knee Arthroplasty Options Comparing Standard Knee Cutting Guides and MRI Generated Patient Specific Custom Cutting Guides

NCT01072019
View directory record Official record
Conditions
Osteoarthritis of the Knee
Interventions
Instrument
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Oct 30, 2026, 7:20 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial for Partial Knee Arthroplasty

NCT05037734
View directory record Official record
Conditions
Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic
Interventions
Persona Partial Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional

Progressive Rehabilitation Following Total Knee Arthroplasty

NCT01537328
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total knee replacement rehabilitation
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 30, 2026, 7:20 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Using a Smartphone App to Aid in Functional Mobility Return Following Total Knee Arthroplasty

NCT03607461
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Smartphone App, Control Group
Device · Combination Product
Lead sponsor
Lagniappe Physical Therapy
Other
Eligibility
45 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Shreveport, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2018 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional Results available

Evaluating Advantages of Prevena After Hip and Knee Arthroplasty

NCT01854138
View directory record Official record
Conditions
Infection of Total Hip Joint Prosthesis
Interventions
Prevena Incision Management System
Device
Lead sponsor
ProMedica Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Oct 30, 2026, 7:20 PM EDT
Terminated Not applicable Interventional Results available

PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

NCT01081886
View directory record Official record
Conditions
Degenerative Joint Disease, Osteoarthritis
Interventions
PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
Device
Lead sponsor
Medtronic Surgical Technologies
Industry
Eligibility
21 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Rochester Hills, Michigan • Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique

NCT03148379
View directory record Official record
Conditions
Osteoarthritis
Interventions
Customized patient instruments, Traditional Metal Instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
5
States / cities
Marrero, Louisiana • Billings, Montana • Meadville, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Oct 30, 2026, 7:20 PM EDT
Completed No phase listed Observational

In Vivo Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant

NCT01882751
View directory record Official record
Conditions
Complications; Arthroplasty
Interventions
Conformis CR Total Knee Replacement, Off the Shelf
Device
Lead sponsor
Restor3D
Industry
Eligibility
40 Years to 70 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Oct 30, 2026, 7:20 PM EDT
Completed Phase 2 Interventional Results available

Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

NCT00710840
View directory record Official record
Conditions
Osteoarthritis
Interventions
Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Boulder, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 10, 2015 · Synced Oct 30, 2026, 7:20 PM EDT