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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:36 PM EDT

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Showing 1–24 of 124 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Transcranial Ultrasound Clear all
Withdrawn Not applicable Interventional

The Effect of Atrial Fibrillation Hemodynamics on Regulation of Cerebral Blood Flow

NCT00745602
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
non-invasive testing
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuromodulation of Conscious Perception: Investigating Thalamic Roles Through Ultrasonic Stimulation

NCT06083493
View directory record Official record
Conditions
Thalamus
Interventions
LIFUP excitation, LIFUP inhibition
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 40 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 19, 2024 · Synced Oct 23, 2026, 5:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Blood Flow: Age and Gender

NCT02840851
View directory record Official record
Conditions
Healthy, Aging
Interventions
MRI, TCD
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
20 Years to 64 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Oct 23, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

NCT06518785
View directory record Official record
Conditions
Alcohol Use Disorder
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Completed No phase listed Observational

NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients

NCT04548596
View directory record Official record
Conditions
Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure, Ischemic Stroke
Interventions
Transcranial Doppler
Diagnostic Test
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
3
States / cities
Davis, California • San Francisco, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Non-invasive Neurostimulation in Parkinson's Disease

NCT01615718
View directory record Official record
Conditions
Parkinson's Disease
Interventions
low-intensity transcranial electrical stimulation, transcranial ultrasound
Procedure
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
40 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

CLOTBUST Hands-Free: A Phase I/II Pilot Safety Trial

NCT01240356
View directory record Official record
Conditions
Stroke
Interventions
2-MHz transcranial Doppler ultrasound, 2-MHz transcranial Doppler ultrasound insonation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 23, 2016 · Synced Oct 23, 2026, 5:36 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Functional Roles of Dorsolateral Prefrontal Cortex

NCT03882931
View directory record Official record
Conditions
Healthy Participants
Interventions
Theta Burst Transcranial Magnetic Stimulation, Focused Ultrasound, Sham
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 35 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2019 · Synced Oct 23, 2026, 5:36 PM EDT
Not yet recruiting No phase listed Observational

Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury

NCT07772323
View directory record Official record
Conditions
Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus, Stroke, Brain Neoplasm, Hypoxia-Ischemia, Brain
Interventions
Not listed
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
2 Years to 17 Years
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee

NCT01404052
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 23, 2026, 5:36 PM EDT
Active, not recruiting Not applicable Interventional

Optimization of NIBS for Diabetic Neuropathy Neuropathic Pain

NCT03625752
View directory record Official record
Conditions
Diabetic Neuropathies, Chronic Pain
Interventions
Active Comparator: Active tDCS + Active TUS, Sham
Device
Lead sponsor
Case Western Reserve University
Other
Eligibility
40 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Transcranial Doppler(TCD) Evaluation of High Intensity Transient Signals and Carotid Disease

NCT05829200
View directory record Official record
Conditions
Asymptomatic Carotid Stenosis, Symptomatic Carotid Stenosis, TCD, HITS
Interventions
Transcranial Doppler (TCD)
Device
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Not applicable Interventional

Effects of tDCS and tUS on Pain Perception in OA of the Knee

NCT02330315
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 24, 2020 · Synced Oct 23, 2026, 5:36 PM EDT
Not listed Not applicable Interventional Results available

Feasibility Study of ExAblate Thalamotomy for Treatment of Chronic Trigeminal Neuropathic Pain

NCT03309813
View directory record Official record
Conditions
Trigeminal Neuropathic Pain
Interventions
Transcranial ExAblate, Sham Transcranial ExAblate, Crossover Transcranial Exablate
Device
Lead sponsor
InSightec
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Oct 23, 2026, 5:36 PM EDT
Recruiting Not applicable Interventional

Transcranial Ultrasound Via Sonolucent Cranioplasty After Minimally Invasive Intracerebral Hemorrhage Evacuation

NCT05538286
View directory record Official record
Conditions
Transcranial Ultrasound With Sonolucent Cranioplasty, TUSC
Interventions
ClearFit implant, transcranial ultrasonography through sonolucent cranioplasty
Device · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Terminated Phase 1Phase 2 Interventional

Transcranial Ultrasound in Clinical SONothrombolysis

NCT00504842
View directory record Official record
Conditions
Acute Ischemic Stroke
Interventions
MRX-801, Placebo
Drug
Lead sponsor
ImaRx Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
13
States / cities
Birmingham, Alabama • Phoenix, Arizona • Newport Beach, California + 9 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2008 · Synced Oct 23, 2026, 5:36 PM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease

NCT04218084
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Voxelotor, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
2 Years to 14 Years
Enrollment
236 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
13
States / cities
Washington D.C., District of Columbia • Miami, Florida • Atlanta, Georgia + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Not yet recruiting Early Phase 1 Interventional

Causal Mechanisms of Odor-Guided Behavior in Humans

NCT07099092
View directory record Official record
Conditions
Normal Physiology
Interventions
TUS PirC, TUS Amy, TUS Sham
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2035
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Completed Not applicable Interventional Results available

Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors

NCT02289560
View directory record Official record
Conditions
Essential Tremor
Interventions
Transcranial ExAblate
Device
Lead sponsor
InSightec
Industry
Eligibility
22 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
7
States / cities
Stanford, California • Baltimore, Maryland • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 23, 2026, 5:36 PM EDT
Enrolling by invitation Not applicable Interventional

Mapping LIFU Responses Using iEEG Recordings

NCT07518927
View directory record Official record
Conditions
Low Intensity Focussed Ultrasound, Electrodes, Implanted
Interventions
Low Intensity Focused Ultrasound
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Terminated No phase listed Observational

BRAIN-HEART Ultrasound Study Normative Values for Transcranial Doppler Based Cerebral Blood Flow Assessment

NCT05924503
View directory record Official record
Conditions
Mechanical Circulatory Support
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Suspended Not applicable Interventional

Low-Intensity Focused Ultrasound Neuromodulation of the Mediodorsal Thalamus for Treatment-Resistant Schizophrenia

NCT05259306
View directory record Official record
Conditions
Treatment-resistant Schizophrenia
Interventions
Insightec Exablate Neuro MR-guided focused ultrasound transducer
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 23, 2026, 5:36 PM EDT
Active, not recruiting No phase listed Interventional Results available

Effects of tDCS and tUS on Pain Perception in OA of the Knee

NCT02723929
View directory record Official record
Conditions
Chronic Pain, Osteoarthritis
Interventions
active low-intensity transcranial electrical stimulation/active transcranial ultrasound, Sham low-intensity transcranial electrical stimulation/sham transcranial ultrasound
Device
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 23, 2026, 5:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury

NCT04242602
View directory record Official record
Conditions
Traumatic Brain Injury, Brain Injuries, Brain Injury, Vascular
Interventions
Transcranial Doppler
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
28 Days to 18 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 23, 2026, 5:36 PM EDT