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ClinicalTrials.gov public records Last synced Nov 5, 2026, 7:35 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Transdermal Lidocaine Clear all

Conditions: Radial Artery Spasm, Angina, Coronary Artery Disease
Interventions: Topical Nitroglycerine, Topical Lidocaine; Drug
Lead sponsor: Aultman Health Foundation; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Canton, Ohio

Conditions: Tinnitus
Interventions: DMSO-based otic solution with betahistine, dexamethasone, and lidocaine, DMSO-based transdermal cream with levocarnitine and N-acetylcysteine; Drug
Lead sponsor: Leading Edge Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Ithaca, New York

Conditions: Heat Effect
Interventions: Lidocaine patch; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years to 45 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Carpal Tunnel Syndrome
Interventions: Synera (lidocaine 70 mg and tetracaine 70 mg) topical patch; Drug
Lead sponsor: ZARS Pharma Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Overland Park, Kansas

Conditions: Osteoarthritis of the Knee
Interventions: Lidoderm (Lidocaine 5% Patch), Placebo Patch; Drug
Lead sponsor: Endo USA Inc., a Keenova Therapeutics Company; Industry
Eligibility: 37 Years and older
Enrollment: 169 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 20
States / cities: Paradise Valley, Arizona • Phoenix, Arizona • Milford, Connecticut + 16 more

Conditions: Rhytidoplasty
Interventions: clonidine, glycopyrrolate, propofol, ketamine, marcaine, scopolamine, midazolam, ondansetron, metoclopramide, lidocaine, famotidine, desflurane, sevoflurane; Drug · Device
Lead sponsor: Mercy Facial Plastic Surgery Center; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Springfield, Missouri

Conditions: Healthy
Interventions: Lidocaine 5% patch, Lidocaine hydrochloride, Lidoderm 5% patch; Drug
Lead sponsor: Nicole K Brogden; Other
Eligibility: 18 Years to 65 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Needle Phobia
Interventions: Lidocaine patch 4%, Placebo Patch, 1% Lidocaine Skin Wheal; Drug · Other
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Chronic Low Back Pain
Interventions: Lidoderm®, Placebo Topical Patch; Drug
Lead sponsor: Endo USA Inc., a Keenova Therapeutics Company; Industry
Eligibility: 18 Years and older
Enrollment: 215 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 18
States / cities: Birmingham, Alabama • Phoenix, Arizona • Carlsbad, California + 15 more

Conditions: Diabetic Peripheral Neuropathy
Interventions: Skin biopsy, Lidocaine 5% patches; Procedure · Drug
Lead sponsor: Albany Medical College; Other
Eligibility: 18 Years to 70 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2015
U.S. locations: 1
States / cities: Albany, New York

Conditions: Back Pain, Arthritis
Interventions: lidocaine 5% patch, lidocaine 3.6%, menthol 1.25%, Placebo; Drug
Lead sponsor: J.A.R. Laboratories; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Barrington, Illinois

Conditions: Low Back Pain
Interventions: lidocaine 5% patch, standard therapy, Non-medicated patch; Drug
Lead sponsor: Cook County Health; Government
Eligibility: 24 Years to 64 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Tinnitus
Interventions: Transdermal Lidocaine; Drug
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Nonspecific Pain Post Traumatic Injury
Interventions: Acetaminophen IV/PO, Acetaminophen PO, Ketorolac, Celebrex, Naproxen, Tramadol, Pregabalin, Gabapentin, Lidocaine, Opioids, Regional anesthesia; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 16 Years and older
Enrollment: 1,561 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Perioperative Chest Pain
Interventions: Lidoderm 5 % Topical Patch, Placebo patch; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Pain on Propofol IV Injection
Interventions: lidocaine/tetracaine transdermal patch (NDC 43469-864-01), Gebauer's Ethyl Chloride; Device · Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 6 Years to 17 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Shoulder Pain
Interventions: Synera® (lidocaine 70 mg and tetracaine 70 mg) topical patch, Triamcinolone Acetonide; Drug
Lead sponsor: Injury Care Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Pain, Postoperative
Interventions: Lidoderm 5 % Topical Patch, Sham Topical Patch; Drug · Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 18 Years to 89 Years · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Moderate to Severe Acute Lower Back Pain
Interventions: SP-103, Placebo; Drug
Lead sponsor: Scilex Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 10
States / cities: Phoenix, Arizona • Fernandina Beach, Florida • Jacksonville, Florida + 7 more

Conditions: Pain on IV Injection of Propofol.
Interventions: Lidocaine/tetracaine transdermal patch, Saline, Lidocaine; Device · Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 6 Years to 17 Years
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Pain
Interventions: lidocaine 70mg and tetracaine 70mg topical patch; Drug
Lead sponsor: ZARS Pharma Inc.; Industry
Eligibility: Up to 4 Months
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Metabolic Syndrome
Interventions: intravenous glucose tolerance test, testosterone, anastrozole, goserelin acetate implant, aerobic capacity (VO2 Max), MRI, muscle biopsy, measurement of resting metabolic rate (energy expenditure), Dual energy x-ray absorptiometry, Fasting oral glucose tolerance test; Procedure · Drug
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH
Eligibility: 50 Years to 75 Years · Male only
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 2
States / cities: Baltimore, Maryland • Boston, Massachusetts

Conditions: Rib Fractures
Interventions: Placebo Patch, 4% Lidocaine Patch; Other · Drug
Lead sponsor: Medical College of Wisconsin; Other
Eligibility: 65 Years and older
Enrollment: 5 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Milwaukee, Wisconsin

Conditions: Osteoarthritis, Knee
Interventions: Lidoderm, Placebo patch; Drug
Lead sponsor: Endo USA Inc., a Keenova Therapeutics Company; Industry
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 24
States / cities: Birmingham, Alabama • Hueytown, Alabama • Tallassee, Alabama + 21 more

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Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention

DMSO Dual-Route Therapy for Refractory Tinnitus in Long-COVID and Post-COVID-19 Vaccine Injury

PK and DPK of Lidocaine Dermal Products

Open-Label Study Evaluating Synera® in the Treatment of Patients With Carpal Tunnel Syndrome

Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee

Anesthetics in Rhytidoplasty - A Comparison Study

Pharmacokinetics of Lidocaine in Healthy Adults

Lidocaine Patch for Epidural Placement Pain in Laboring Women

A Study Comparing The Efficacy And Safety Of Lidocaine 5% Patch With Placebo In Patients With Chronic Axial Low Back Pain

Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy

Comparison of Prescription Lidocaine Patch to Over the Counter Lidocaine Patch and Placebo for Back Pain and Arthritis

Adjunctive 5% Lidocaine Patches for Acute Non-radicular Low Back Pain in Emergency Department Patients

Commercial Lidocaine Patch as a Treatment for Ear-ringing

MAST Trial: Multi-modal Analgesic Strategies in Trauma

Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery

In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?

Pain Patch Versus Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome

Post-Op Lidocaine Patch

Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain

Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection

Pharmacokinetic Study of Synera™ in Neonates and Infants

Insulin Sensitivity in Men With the Metabolic Syndrome

Lidocaine Patches in Elderly Patients With Traumatic Rib Fractures

Pilot Study of Lidocaine 5% Patch Versus Placebo in Patients With Osteoarthritis Pain of the Knee