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Showing 1–24 of 139 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Transdermal Nicotine Patch Clear all
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers

NCT01907594
View directory record Official record
Conditions
Cigarette Smoking
Interventions
D-cycloserine, Nicotine Replacement Therapy (patch), Smoking Cue Exposure, Progressive Muscle Relaxation, Placebo
Drug · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 55 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced Sep 2, 2026, 1:17 AM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.

NCT06053567
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Aerobic Exercise, Counseling, Nicotine patch
Behavioral · Drug
Lead sponsor
Jasper A. Smits
Other
Eligibility
18 Years and older
Enrollment
360 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 3 Interventional Results available

Behavioral Activation Intervention, Reward Processing, and Youth Smoking Cessation

NCT01351766
View directory record Official record
Conditions
Smoking
Interventions
Transdermal Nicotine Patch
Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 21 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 3 Interventional Results available

Pharmacogenetics of Nicotine Addiction Treatment

NCT01314001
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Varenicline, Placebo, Transdermal Nicotine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
1,246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
3
States / cities
Buffalo, New York • Philadelphia, Pennsylvania • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Sep 2, 2026, 1:17 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Physical Activity in Promoting Smoking Cessation in African Americans

NCT01915810
View directory record Official record
Conditions
Current Smoker, Healthy Subject
Interventions
Exercise Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 2, 2026, 1:17 AM EDT
Terminated Not applicable Interventional Results available

Analysis of Lipid Biomarkers of Exposure and Host Response

NCT00493831
View directory record Official record
Conditions
Cigarette Smoking
Interventions
nicotine polacrilex, transdermal system or inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

UW-CTRI Triple Medication Smoking Cessation Study

NCT02681510
View directory record Official record
Conditions
Smoking
Interventions
Varenicline, Nicotine Transdermal Patch, Nicotine Mini
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment

NCT01372254
View directory record Official record
Conditions
Cigarette Smoking, Drug Use
Interventions
Standard Treatment, BAD-AS, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 17, 2022 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Contingency Management for Smoking Cessation in the Homeless

NCT01736982
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Contingency Management, Standard of Care
Behavioral · Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
New Britain, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Results available

Progesterone Augmentation of Nicotine Replacement Therapy Study

NCT02685072
View directory record Official record
Conditions
Smoking Cessation
Interventions
Progesterone (200 mgs BID), Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Strategies to Help Adult ED Patients Quit Smoking

NCT00297466
View directory record Official record
Conditions
Tobacco Use
Interventions
transdermal nicotine patches, Motivational interview
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation Intervention in Public Housing

NCT01035151
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Experimental, Control
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Female only
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
2
States / cities
Augusta, Georgia • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Sep 2, 2026, 1:17 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Naltrexone and Patch for Smokers

NCT00018213
View directory record Official record
Conditions
Smoking
Interventions
Naltrexone Hydrochloride, Transdermal Nicotine
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2001
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional Results available

Smoking Treatment and Exercise Program for Underserved Populations (STEP UP)

NCT02873754
View directory record Official record
Conditions
Smoking
Interventions
Cognitive Behavioral Counseling, Mobile Contingency Management, Bupropion, Transdermal nicotine patch, Nicotine polacrilex, Nicotine lozenge
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 70 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2018 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Smoking Cessation in Women With Gynecological Conditions

NCT01989923
View directory record Official record
Conditions
Cervical Dysplasia
Interventions
Nicotine Replacement Therapy, Electronic Cigarettes
Other · Device
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Results available

Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking

NCT02995915
View directory record Official record
Conditions
Smoking Cessation, Alcohol Drinking
Interventions
Nicotine Replacement Therapy, Bupropion, Cognitive Behavioral Treatment, Mobile Contingency Management, Mobile Monitoring
Other · Drug · Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 80 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Sep 2, 2026, 1:17 AM EDT
Active, not recruiting Not applicable Interventional

Smoking Cessation Intervention for Cancer Patients

NCT00575718
View directory record Official record
Conditions
Newly Diagnosed Cancer Patients
Interventions
Hospital Counseling + Nicotine Replacement Therapy. questionaires, Hospital Counseling + Nicotine Replacement + Presurgical Scheduled Reduced Smoking, questionaires
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 1 Interventional

Smoking Termination / Anxiety Reduction Treatment (ST/ART)

NCT01789125
View directory record Official record
Conditions
Smoking, Anxiety Disorders
Interventions
Nicotine Patch, Smoking Termination and Anxiety Reduction Treatment, Education-Supportive Psychotherapy
Drug · Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Patch, Blood Flow and Oxidative Stress Study

NCT00954096
View directory record Official record
Conditions
Healthy
Interventions
transdermal nicotine patch (7mg)
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2009 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Results available

Tobacco Treatment Comparison for Cancer Care

NCT06218823
View directory record Official record
Conditions
Smoking Cessation, Cancer
Interventions
Transdermal Nicotine Patch, Standard Telephone Counseling, Varenicline, Cancer-Targeted Telephone Counseling, Mailed Information about Standard Care Resources
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia

NCT00373126
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder
Interventions
transdermal nicotine patch
Drug
Lead sponsor
North Suffolk Mental Health Association
Other
Eligibility
18 Years to 60 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2005
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2009 · Synced Sep 2, 2026, 1:17 AM EDT
Completed Not applicable Interventional

Women Engaging in Quitting Smoking Together

NCT02453659
View directory record Official record
Conditions
Smoking Cessation
Interventions
Distress Tolerance Treatment for Weight Concern (DT-W), Health Education (HE), Smoking Cessation counseling, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Sep 2, 2026, 1:17 AM EDT
Terminated Not applicable Interventional Results available

Analysis of Aldehyde Biomarkers of Exposure and Host Response

NCT00482690
View directory record Official record
Conditions
Smoking Cessation
Interventions
nicotine polacrilex, nicotine transdermal system, nicotine inhaler
Drug
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Sep 2, 2026, 1:17 AM EDT