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Conditions: Cardiac Disease
Interventions: Not listed
Lead sponsor: Scripps Translational Science Institute; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Heart Failure
Interventions: Heart Ultrasound; Device
Lead sponsor: Geisinger Clinic; Other
Eligibility: 18 Years to 89 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Wilkes-Barre, Pennsylvania

Conditions: Heart Failure, Cardiovascular Diseases
Interventions: NT-proBNP; Diagnostic Test
Lead sponsor: NHS Greater Glasgow and Clyde; Other
Eligibility: 40 Years and older
Enrollment: 3,904 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2032
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Cardiomyopathy, Ischemic Heart Disease, Cardiac Amyloidosis
Interventions: Transthoracic Echocardiography (TTE); Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 10,040,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Plasma Cell Leukemia
Interventions: Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Carfilzomib, Computed Tomography, Daratumumab and Recombinant Human Hyaluronidase, Dexamethasone, Fludeoxyglucose F-18, Lenalidomide, Magnetic Resonance Imaging, Melphalan, Plerixafor, Positron Emission Tomography, Recombinant Granulocyte Colony-Stimulating Factor, Stem Cell Isolation, Teclistamab, Transthoracic Echocardiography Test; Procedure · Drug · Other + 1 more
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 18 Years to 80 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2032
U.S. locations: 8
States / cities: Baton Rouge, Louisiana • Middletown, New Jersey • Montvale, New Jersey + 5 more

Conditions: Obstetric Anesthesia, Cardiac Monitoring
Interventions: TTE / NICOM; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cardiogenic Shock
Interventions: Not listed
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Sickle Cell Disease
Interventions: MRI, Transthoracic Echocardiography, tonometry, EKG; Procedure
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Ventricular Function, Right
Interventions: Concurrent TTE and TEE; Other
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 90 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: COVID-19
Interventions: Caption AI; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 2
States / cities: Durham, North Carolina

Conditions: Valve Heart Disease
Interventions: MRI, Transthoracic echocardiography exam; Other
Lead sponsor: CryoLife, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Embolic Stroke of Undetermined Source, Transient Ischemic Attack, Right-To-Left Atrial Shunt, Patent Foramen Ovale
Interventions: NeuralBot Investigational System, Transthoracic Echocardiography (TTE); Diagnostic Test
Lead sponsor: NeuraSignal Inc dba NovaSignal; Industry
Eligibility: 18 Years and older
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 7
States / cities: Phoenix, Arizona • Portland, Oregon • Chattanooga, Tennessee + 3 more

Conditions: Paroxysmal Atrial Fibrillation
Interventions: Self- Report Evaluation-Duke Activity Status Index, Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire, Cardiopulmonary exercise test (CPET), Transthoracic echocardiogram, Ambulatory cardiac rhythm assessment, Cardiovascular magnetic resonance (CMR); Behavioral · Diagnostic Test
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Right to Left Shunt, Patent Foramen Ovale, Atrial Septal Defect
Interventions: Flow Detection System; Device
Lead sponsor: Cardiox Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 141 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 8
States / cities: Phoenix, Arizona • Los Angeles, California • Aurora, Colorado + 5 more

Conditions: Her 2 Positive Breast Cancer
Interventions: Transthoracic echocardiogram (ultrasound); Procedure
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Transthoracic Echocardiography, Suspected or Known Structural or Functional Cardiac Abnormality
Interventions: Optison; Drug
Lead sponsor: GE Healthcare; Industry
Eligibility: 9 Years to 17 Years
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 8
States / cities: Phoenix, Arizona • Los Angeles, California • Augusta, Georgia + 5 more

Conditions: Pulmonary Hypertension, Pulmonary Vascular Disease, Left Heart Disease
Interventions: Transthoracic Echocardiography (TTE), Lung ultrasound; Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: Lisdexamfetamine; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Myocardial Stiffness
Interventions: Stress Echocardiogram, Cardiovascular Magnetic Imaging (cMRI), Cardiac Magnetic Resonance Elastography (cMRE); Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 40 Years to 70 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Ischemic Stroke, Cryptogenic, Ischemic Stroke, Embolic, Hemorrhagic Stroke, Embolic Stroke of Undetermined Source, Recurrent Ischemic Stroke
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 900 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Heart Failure
Interventions: R Drink; Dietary Supplement
Lead sponsor: Ohio State University; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cardiac Disease
Interventions: MyoVista wavECG Test; Device
Lead sponsor: Heart Test Laboratories, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 575 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 5
States / cities: La Jolla, California • Boston, Massachusetts • The Bronx, New York + 2 more

Conditions: Aortic Stenosis
Interventions: Tranthoracic Echocardiogram, Cardiac Ascultation Recordings with Electronic stethoscope; Other · Device
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: San Diego, California

Conditions: Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions: AI Toolkit for ATTR-CM Diagnosis; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 50 Years to 95 Years
Enrollment: 1,500,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 12
States / cities: San Francisco, California • New Haven, Connecticut • Chicago, Illinois + 9 more

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Comparitive Effectiveness of PME Versus Transthoracic Echocardiogram (TTE)

Intra-procedural Transthoracic EChocardiogram to Facilitate Left Bundle Branch Area Pacing (LBBAP)

Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial

Cardiac Output Changes With Uterine Displacement

Establishing Physiologic Outcomes for Ventricular Unloading on VA ECMO

Cardiovascular Complications of Sickle Cell Disease

Speckle-tracking Tricuspid Annular Plane Systolic Excursion

CAPTION AI to Minimize Risk of COVID Exposure

Post-surgical Aortic Hemodynamics After Aortic Valve Replacement

RoBotic TCD Ultrasound BubbLe Study Compared to Transthoracic Echocardiography for Detection of Right to Left Shunt

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Right to Left Cardiac Shunt Detection

Strain Imaging in Breast Cancer Patients Receiving Trastuzumab

Study to Determine Safety and Dosage of OPTISON in Pediatric Participants

Pulmonary Hypertension in Left Heart Disease

Cardiovascular Study of Lisdexamfetamine in Healthy and Hypertensive Attention Deficit Hyperactivity Disorder Adults

The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.

Left Atrial Strain and Cryptogenic Stroke

Dietary Supplementation in Heart Failure

MyoVista wavECG Clinical Validation Study Versus Low e' on Echocardiogram

Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography

An Observational Study Using Artificial Intelligence (AI) Algorithms on Electrocardiography (ECG), Point-of-care Ultrasound (POCUS), and Transthoracic Echocardiophy (TTE) to Estimate the Under-diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Across a Diverse Range of US Health Systems.