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Conditions: Hereditary Hemorrhagic Telangiectasia (HHT)
Interventions: Transthoracic Contrast Echocardiogram; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 89 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Heart Diseases, Lung Diseases
Interventions: Integrated CardioRespiratory System, Transthoracic Echocardiography (TTE), Electrocardiography; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Coronary Artery Disease
Interventions: MyoVista device, Computed tomographic coronary angiography, Transthoracic Echocardiography; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Ventricular Dysfunction, Left, Ventricular Function, Left, Echocardiography, Ultrasonography, Point-of-Care Systems, Heart Function Tests, Stroke Volume, Federated Learning, Machine Learning, Artificial Intelligence (AI), Deep Learning, Neural Networks, Computer, Image Interpretation, Computer-Assisted, Diagnosis, Computer-Assisted, Sensitivity and Specificity, ROC Curve
Interventions: Focused Cardiac Point-of-Care Ultrasonography, FL-POCUS Federated Machine-Learning Analysis System; Diagnostic Test · Device
Lead sponsor: Truway Health, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2037
U.S. locations: 1
States / cities: New York, New York

Conditions: Amyloidosis Cardiac, Healthy Adults
Interventions: Cardiac magnetic resonance image (CMR), Transthoracic Echocardiogram (TTE), Six-minute Walk Test; Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 40 Years and older
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Heart Failure and Reduced Ejection Fraction, Functional Mitral Regurgitation
Interventions: Cardiac MRI; Diagnostic Test
Lead sponsor: Minneapolis Heart Institute Foundation; Other
Eligibility: 18 Years and older
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 5
States / cities: Minneapolis, Minnesota • Charlotte, North Carolina • Cincinnati, Ohio + 2 more

Conditions: Preeclampsia
Interventions: Transthoracic Echocardiography; Diagnostic Test
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 55 Years · Female only
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Pulmonary Hypertension, Interstitial Lung Disease (ILD)
Interventions: ECG-based AI Device - Results Returned to Investigator, Echocardiogram and Right Heart Catheterization, ECG-based AI Device - Results Not Returned to Investigator; Device · Procedure
Lead sponsor: Tempus AI; Industry
Eligibility: 18 Years and older
Enrollment: 900 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 37
States / cities: Birmingham, Alabama • Phoenix, Arizona • Riverside, California + 29 more

Conditions: Pulmonary Hypertension, Pulmonary Vascular Disease, Left Heart Disease
Interventions: Transthoracic Echocardiography (TTE), Lung ultrasound; Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Ventricular Cardiomyopathy, Arrhythmogenic Cardiomyopathy, Ventricular Tachycardia, Sudden Cardiac Death
Interventions: ECG, Echocardiography, Cardiac MRI, Ambulatory ECG recording, Cardiac EP study, All study subjects will undergo sample collection for genetic testing.; Diagnostic Test · Genetic
Lead sponsor: Sheri Kashmir Institute of Medical Sciences; Other
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Ventricular Dysfunction, Pericardial Effusion, Valvular Disease, Septal Defect
Interventions: Philips EPIQ 7 ultrasound machine, Philips Lumify Broadband sector array transducer; Device
Lead sponsor: University of Miami; Other
Eligibility: Not listed
Enrollment: 47 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Maternity, Pregnancy, Labor and Delivery, Hemodynamic Changes
Interventions: ClearSight™ System, Transthoracic Echocardiography, Passive Leg Raising (PLR) Maneuver; Device · Procedure
Lead sponsor: Ayse Zeynep Turan Civraz; Government
Eligibility: 18 Years to 45 Years · Female only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Cardiomyopathy, Ischemic Heart Disease, Cardiac Amyloidosis
Interventions: Transthoracic Echocardiography (TTE); Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 10,040,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Ventricular Function, Right, Echocardiography, Transesophageal
Interventions: Transesophageal Echocardiography, Transthoracic Echocardiography; Diagnostic Test
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 126 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Critical Illness, Pediatrics
Interventions: Ultrasonic Cardiac Output Monitor (USCOM).; Device
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 1 Day to 17 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Her 2 Positive Breast Cancer
Interventions: Transthoracic echocardiogram (ultrasound); Procedure
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Obstetric Anesthesia, Cardiac Monitoring
Interventions: TTE / NICOM; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Hypotension
Interventions: Not listed
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2026
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Myocardial Stiffness
Interventions: Stress Echocardiogram, Cardiovascular Magnetic Imaging (cMRI), Cardiac Magnetic Resonance Elastography (cMRE); Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 40 Years to 70 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Hypertrophic Cardiomyopathy (HCM), Cardiac Imaging, Echocardiography, Mavacamten, Obstructive Cardiomyopathy, Hypertrophic
Interventions: Not listed
Lead sponsor: UltraSight; Industry
Eligibility: 18 Years and older
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Prostate Cancer
Interventions: Transthoracic Echocardiography, Arterial blood pressure, Submaximal Exercise; Diagnostic Test
Lead sponsor: Kansas State University; Other
Eligibility: 21 Years to 80 Years · Male only
Enrollment: 18 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Manhattan, Kansas

Conditions: Echocardiography
Interventions: Investigational ultrasound exam; Device
Lead sponsor: GE Healthcare; Industry
Eligibility: Not listed
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: 3D Transesophageal and Transthoracic Echocardiogram
Interventions: transesophageal echocardiography (TEE), thermodilution, transthoracic echocardiography (TTE); Procedure
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Transthyretin (TTR) Amyloid Cardiomyopathy
Interventions: AI Toolkit for ATTR-CM Diagnosis; Diagnostic Test
Lead sponsor: Yale University; Other
Eligibility: 50 Years to 95 Years
Enrollment: 1,500,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 12
States / cities: San Francisco, California • New Haven, Connecticut • Chicago, Illinois + 9 more

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Graded TTCE for Post-Embolization PAVM Monitoring

Heart and Lung Function Monitoring System

Analysis of Surface EKG Signals to Identify Myocardial Dysfunction in Patients at Risk for Coronary Artery Disease

Federated Learning for Point-of-Care Cardiac Ultrasound

Intracardiac Flow Assessment in Cardiac Amyloidosis

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Pulmonary Hypertension in Left Heart Disease

South Asian Arrhythmogenic Cardiomyopathy Registry

Focused Cardiac Ultrasound

Passive Leg Raising in Term Pregnancy on Hemodynamic Monitoring - Validating With Transthoracic ECHO (LG-ECHO)

A Study Of Deep Learning For Echo Analysis, Tracking, And Evaluation

Validating TEE Measurements of Right Ventricular Function

Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO

Strain Imaging in Breast Cancer Patients Receiving Trastuzumab

Cardiac Output Changes With Uterine Displacement

Use of Ultrasonography to Determine Fluid-responsiveness for Shock in a Population of Intensive Care Unit Patients

The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.

ENABLE-HCM - AI-ENabled Echocardiography With Ultrasound Beyond the Echo Lab for Better HCM Imaging and Expanded Access

Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer

GE CVUS Device Evaluation

Left Ventricular Volume and Ejection Fraction: Validation of Real Time 3 Dimensional Transesophageal Echocardiography

An Observational Study Using Artificial Intelligence (AI) Algorithms on Electrocardiography (ECG), Point-of-care Ultrasound (POCUS), and Transthoracic Echocardiophy (TTE) to Estimate the Under-diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Across a Diverse Range of US Health Systems.