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ClinicalTrials.gov public records Last synced Sep 30, 2026, 6:47 PM EDT

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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Trauma-Focused CBT (TF-CBT) Clear all
Active, not recruiting Not applicable Interventional

Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

NCT05384223
View directory record Official record
Conditions
Substance Use Disorders, PTSD
Interventions
RRFT (Risk Reduction through Family Therapy), ENCOMPASS (Integrated Treatment for Adolescents and Young Adults)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 75 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional

Neural Connectivity During Therapy for Adolescent PTSD

NCT05423444
View directory record Official record
Conditions
PTSD, Adolescent, Psychological Trauma
Interventions
TF-CBT, TAU
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
12 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Technology-Based Tools to Enhance Quality of Care in Mental Health Treatment

NCT01915160
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
eTF-CBT, TF-CBT
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
8 Years to 15 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2016 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Results available

Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya

NCT01822366
View directory record Official record
Conditions
Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms, Behavioral Problems, Child Overall Daily Functioning, Child and Guardian Relationship
Interventions
Trauma-focused Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Duke University
Other
Eligibility
7 Years to 13 Years
Enrollment
1,280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 5, 2021 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Stepped Care for Children After Trauma: Optimizing Treatment

NCT02537678
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Stepped Care TF-CBT, Standard TF-CBT
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
4 Years to 70 Years
Enrollment
183 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
6
States / cities
Jacksonville, Florida • Largo, Florida • New Port Richey, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated May 6, 2022 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Results available

Integrating Animal-Assisted Therapy Into Trauma-Focused Cognitive-Behavioral Therapy for Maltreated Youth

NCT03135119
View directory record Official record
Conditions
Child Abuse, Posttraumatic Stress
Interventions
TF-CBT, TF-CBT+AAT
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
6 Years to 17 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Harrisburg, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Response to Treatment for Pediatric PTSD

NCT01806701
View directory record Official record
Conditions
Emotions, Memory Deficits, Post-traumatic Syndrome
Interventions
Trauma-focused cognitive behavioral therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
9 Years to 17 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2016 · Synced Sep 30, 2026, 6:47 PM EDT
Active, not recruiting Not applicable Interventional

Examining Written Exposure Therapy Delivered to Adolescents

NCT07498257
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD)
Interventions
Written Exposure Therapy, Trauma-focused Cognitive Behavior Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 18 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy

NCT04451161
View directory record Official record
Conditions
Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
Interventions
Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual, Attention Control
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
7 Years to 85 Years
Enrollment
292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 12, 2025 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional

Trauma Informed Prevention for Substance Use and Risky Sex

NCT03710720
View directory record Official record
Conditions
Substance Use, HIV/AIDS
Interventions
TIPS app, Trauma Focused-Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 18 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Resilient Roots: Supporting Youth and Families

NCT06535516
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Socialization (S)
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
10 Years to 15 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Improving Quality of Care in Child Mental Health Service Settings

NCT03305458
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Technology, Child Abuse
Interventions
TFCBT, eTFCBT
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
8 Years to 16 Years
Enrollment
713 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional Results available

Child Characteristics, Neuromarkers, and Intervention Components Impacting Treatment Outcome: CCT, TF-CBT, TAU

NCT02926677
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Cue-Centered Treatment (CCT), Trauma-Focused CBT (TF-CBT), Treatment as Usual, NIRScout
Behavioral · Device
Lead sponsor
Stanford University
Other
Eligibility
7 Years to 18 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
Sacramento, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional

Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence

NCT00183326
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Anxiety, Depression
Interventions
Trauma-focused cognitive behavioral therapy (TF-CBT), Child-centered supportive therapy (CCT)
Behavioral
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
7 Years to 14 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Phase 3 Interventional Results available

Pharmacologic Treatment of PTSD in Sexually Abused Children

NCT00078767
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma-Focused Cognitive Behavioral Therapy, Sertraline Pill, Placebo Oral Tablet
Behavioral · Drug
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
10 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Phase 1Phase 2 Interventional

Stepped Care for Young Children After Trauma

NCT01603563
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Stepped Care TF-CBT, Standard TF-CBT
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
3 Years to 7 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2015 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional

Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)

NCT06941428
View directory record Official record
Conditions
Trauma, Psychological, Trauma and Stressor Related Disorders
Interventions
Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), School-Adapted TF-CBT (S-TF)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
7 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 27, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Not applicable Interventional

Treatment of Post-Traumatic Stress Disorder (PTSD) in Sexually Abused Children

NCT00000383
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma-Focused CBT, Child-Centered Therapy
Behavioral
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
8 Years to 14 Years
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
3
States / cities
Stratford, New Jersey • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 30, 2015 · Synced Sep 30, 2026, 6:47 PM EDT
Not yet recruiting Not applicable Interventional

Using a Primary Care- Based Stepped-Care Model of Trauma Focused Cognitive Behavioral Therapy (PSC-TF-CBT)to Reduce Trauma Symptoms and Negative Mental Health Sequelae

NCT07797400
View directory record Official record
Conditions
Trauma Patients
Interventions
PSC-TF-CBT
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
8 Years to 14 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (RCT)

NCT07396974
View directory record Official record
Conditions
Trauma, Posttraumatic Stress Disorder
Interventions
Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT), Treatment as Usual (TAU)
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
7 Years to 14 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional

Considering Racial and Acculturation Stress in Addressing Trauma

NCT05974176
View directory record Official record
Conditions
Trauma-related PTSD
Interventions
Trauma Focused CBT (TF-CBT), Trauma Systems therapy (TST)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
5 Years to 17 Years
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional

TF-CBT for Autistic Youth Pilot Implementation - Open Pilot

NCT07420478
View directory record Official record
Conditions
Autism Spectrum Disorder, PTSD and Trauma-related Symptoms, Autism, Trauma and Stressor Related Disorders, Mental Health Services
Interventions
Trauma-Focused Cognitive Behavioral Therapy, modified for autistic youth
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
6 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 30, 2026, 6:47 PM EDT
Completed Phase 3 Interventional

Optimal Treatment Strategies for Sexually Abused Children

NCT00073684
View directory record Official record
Conditions
Child Abuse, Sexual
Interventions
Trauma focused cognitive behavioral therapy (TF-CBT), Brief abuse-focused treatment, Brief coping skills treatment, Extended abuse-focused treatment, Extended coping skills treatment
Behavioral
Lead sponsor
Rowan University
Other
Eligibility
4 Years to 11 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Stratford, New Jersey
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Sep 30, 2026, 6:47 PM EDT
Recruiting Not applicable Interventional

Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

NCT06332209
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Trauma Focused Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
7 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 30, 2026, 6:47 PM EDT