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Conditions: Substance Use Disorders, PTSD
Interventions: RRFT (Risk Reduction through Family Therapy), ENCOMPASS (Integrated Treatment for Adolescents and Young Adults); Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 13 Years to 75 Years
Enrollment: 212 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Aurora, Colorado • Denver, Colorado

Conditions: Evidence-Based Practices, CBT, School Health Services, Trauma, Psychological
Interventions: Beliefs and Attitudes for Successful Implementation in Schools (BASIS), Trauma-Focused Cognitive-Behavioral Therapy, Treatment as Usual, Attention Control; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 7 Years to 85 Years
Enrollment: 292 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Stress Disorders, Post-Traumatic
Interventions: Trauma-Focused CBT, Child-Centered Therapy; Behavioral
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 8 Years to 14 Years
Enrollment: 229 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1997 – 2002
U.S. locations: 3
States / cities: Stratford, New Jersey • Pittsburgh, Pennsylvania

Conditions: Post-Traumatic Stress Disorder
Interventions: Trauma-focused cognitive behavioral therapy (TF-CBT), Treatment as usual (TAU); Behavioral
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 8 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 8
States / cities: New York, New York

Conditions: Posttraumatic Stress Disorder (PTSD)
Interventions: Written Exposure Therapy, Trauma-focused Cognitive Behavior Therapy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 18 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Trauma-related PTSD
Interventions: Trauma Focused CBT (TF-CBT), Trauma Systems therapy (TST); Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 5 Years to 17 Years
Enrollment: 237 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Emotions, Memory Deficits, Post-traumatic Syndrome
Interventions: Trauma-focused cognitive behavioral therapy; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 9 Years to 17 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Posttraumatic Stress Disorder
Interventions: Trauma-Focused Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Delaware Division of Prevention and Behavioral Health Services; Government
Eligibility: 7 Years to 17 Years
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Wilmington, Delaware

Conditions: Posttraumatic Stress Disorder
Interventions: Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) augmented with Socialization (S); Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 10 Years to 15 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Autism Spectrum Disorder, PTSD and Trauma-related Symptoms, Autism, Trauma and Stressor Related Disorders, Mental Health Services
Interventions: Trauma-Focused Cognitive Behavioral Therapy, modified for autistic youth; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 6 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Trauma, Psychological, Trauma and Stressor Related Disorders
Interventions: Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), School-Adapted TF-CBT (S-TF); Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 7 Years and older
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Posttraumatic Stress Disorder
Interventions: Stepped Care TF-CBT, Standard TF-CBT; Behavioral
Lead sponsor: University of South Florida; Other
Eligibility: 3 Years to 7 Years
Enrollment: 63 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Child Abuse, Sexual
Interventions: Trauma focused cognitive behavioral therapy (TF-CBT), Brief abuse-focused treatment, Brief coping skills treatment, Extended abuse-focused treatment, Extended coping skills treatment; Behavioral
Lead sponsor: Rowan University; Other
Eligibility: 4 Years to 11 Years
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Stratford, New Jersey

Conditions: Post Traumatic Stress, Overall Functioning, Clinician Fidelity, Supervision
Interventions: Supervision Practices of TF-CBT; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 6 Years to 17 Years
Enrollment: 1,280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms, Behavioral Problems, Child Overall Daily Functioning, Child and Guardian Relationship
Interventions: Trauma-focused Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 7 Years to 13 Years
Enrollment: 1,280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Stress Disorders, Post-Traumatic
Interventions: Trauma-Focused Cognitive Behavioral Therapy, Sertraline Pill, Placebo Oral Tablet; Behavioral · Drug
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 10 Years to 17 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Substance Use, HIV/AIDS
Interventions: TIPS app, Trauma Focused-Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 12 Years to 18 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Stress Disorders, Post-Traumatic, Anxiety, Depression
Interventions: Trauma-focused cognitive behavioral therapy (TF-CBT), Child-centered supportive therapy (CCT); Behavioral
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 7 Years to 14 Years
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Psychological Trauma, Mental Health
Interventions: COAST-IS, TF-CBT Learning Collaborative; Other
Lead sponsor: Washington University School of Medicine; Other
Eligibility: Not listed
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Trauma, Posttraumatic Stress Disorder
Interventions: Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT); Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 7 Years to 14 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Post-Traumatic Stress Disorder
Interventions: Trauma Focused Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 7 Years to 18 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Post Traumatic Stress Disorder
Interventions: eTF-CBT, TF-CBT; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 8 Years to 15 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: PTSD, Adolescent, Psychological Trauma
Interventions: TF-CBT, TAU; Behavioral
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 12 Years to 17 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Trauma Patients
Interventions: PSC-TF-CBT; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 8 Years to 14 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

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Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

A Hybrid Type 2 Trial of Trauma-Focused Cognitive Behavioral Therapy and a Pragmatic Individual-Level Implementation Strategy

Treatment of Post-Traumatic Stress Disorder (PTSD) in Sexually Abused Children

Effectiveness of Trauma-Focused Cognitive Behavioral Therapy in Treating Children With Post-Traumatic Stress Disorder

Examining Written Exposure Therapy Delivered to Adolescents

Considering Racial and Acculturation Stress in Addressing Trauma

Brain Response to Treatment for Pediatric PTSD

Trauma-Focused Cognitive Behavior Therapy for Youth: Effectiveness in a Community Setting

Resilient Roots: Supporting Youth and Families

TF-CBT for Autistic Youth Pilot Implementation - Open Pilot

Systematic Redesign of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)

Stepped Care for Young Children After Trauma

Optimal Treatment Strategies for Sexually Abused Children

Randomized Controlled Trial of Supervision Strategies to Improve Clinician Fidelity to Trauma-focused CBT

Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya

Pharmacologic Treatment of PTSD in Sexually Abused Children

Trauma Informed Prevention for Substance Use and Risky Sex

Treating Post Traumatic Stress Disorder in Children Exposed to Domestic Violence

Collaborative Organizational Approach to Selecting and Tailoring Implementation Strategies

Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)

Randomized Trial of Tele Vs. Clinic TF-CBT in Puerto Rico

Technology-Based Tools to Enhance Quality of Care in Mental Health Treatment

Neural Connectivity During Therapy for Adolescent PTSD

Using a Primary Care- Based Stepped-Care Model of Trauma Focused Cognitive Behavioral Therapy (PSC-TF-CBT)to Reduce Trauma Symptoms and Negative Mental Health Sequelae