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Showing 1–24 of 89 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Trauma-focused psychotherapy Clear all
Recruiting Not applicable Interventional

Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD

NCT07069517
View directory record Official record
Conditions
Insomnia, PTSD - Post Traumatic Stress Disorder, Nightmares
Interventions
Cognitive-Behavioral Therapy for Insomnia (CBTi), Cognitive Behavioral Therapy for Nightmares (CBTn), Written Exposure Therapy (WET), Sleep Hygiene
Behavioral
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years to 65 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Kileen, Texas
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Phase 4 Interventional Results available

Sequenced Treatment Effectiveness for Posttraumatic Stress

NCT04597190
View directory record Official record
Conditions
PTSD
Interventions
Selective serotonin reuptake inhibitor, Serotonin-norepinephrine reuptake inhibitor, Written Exposure Therapy
Drug · Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
15
States / cities
North Little Rock, Arkansas • West Memphis, Arkansas • San Diego, California + 11 more
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Sep 10, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Post-Traumatic Stress Disorder Focused Psychodynamic Psychotherapy

NCT03755401
View directory record Official record
Conditions
PTSD
Interventions
TFPP, TAU
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Disseminating Organizational SBI Services at Trauma Centers

NCT00607620
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Dependence
Interventions
Brief Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
878 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Sep 10, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Multifaceted Intervention to Restore Resilience and Overcome Risk

NCT06988787
View directory record Official record
Conditions
Military Sexual Trauma, Intimate Partner Violence, Brain Injury, Post Traumatic Stress Disorder
Interventions
webSTAIR, ExpoTx, PsychoEd
Behavioral · Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Female only
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 10, 2026, 4:22 PM EDT
Not yet recruiting Not applicable Interventional

Comparing Two Moral Injury Treatments

NCT07710521
View directory record Official record
Conditions
Moral Injury
Interventions
Acceptance and Commitment Therapy for Moral Injury (ACT-MI), Present Centered Therapy for Moral Injury (PCT-MI)
Behavioral
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 89 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed No phase listed Observational

Chronic Pain and Brain Activity in Spinal Cord Injury

NCT01012635
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Hypnosis, Meditation, Neurofeedback training, Two different levels of tDCS
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 15, 2013 · Synced Sep 10, 2026, 4:22 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Optimizing a Technology-based Body and Mind Intervention

NCT05778604
View directory record Official record
Conditions
Fall, Fear of Falling, Physical Inactivity, Sedentary Behavior
Interventions
Physio-feedback, Cognitive reframing, Peer-led exercises, CDC older adults fall prevention
Behavioral
Lead sponsor
University of Central Florida
Other
Eligibility
60 Years and older
Enrollment
340 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Phase 4 Interventional Results available

CPT-SMART for Treatment of PTSD and Cigarette Smoking

NCT03978442
View directory record Official record
Conditions
Smoking, Stress Disorders, Post-Traumatic
Interventions
Smoking Cessation Cognitive Behavioral Therapy (CBT), Bupropion, Cognitive Processing Therapy, Smoking Abstinence Reinforcement Therapy, Yoked Contingency Management
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Trauma Informed Guilt Reduction Therapy

NCT02512445
View directory record Official record
Conditions
Guilt, Shame, Post-traumatic Stress Disorders
Interventions
Trauma Informed Guilt Reduction Therapy, Supportive Care Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
3
States / cities
San Diego, California • Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Sep 10, 2026, 4:22 PM EDT
Recruiting Not applicable Interventional

Neural Connectivity During Therapy for Adolescent PTSD

NCT05423444
View directory record Official record
Conditions
PTSD, Adolescent, Psychological Trauma
Interventions
TF-CBT, TAU
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
12 Years to 17 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Phase 3 Interventional

Maximizing Treatment Outcome and Examining Sleep in Post-traumatic Stress Disorder (PTSD)

NCT01199107
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Prolonged Exposure, Exercise, Wellness Intervention
Behavioral
Lead sponsor
Southern Methodist University
Other
Eligibility
18 Years to 54 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional

A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel

NCT02556645
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders
Interventions
Web-PE Therapy, Therapist-Delivered Present-Centered Therapy
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Atlanta, Georgia • Philadelphia, Pennsylvania • Killeen, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2019 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Peer Social Support During In Vivo Exposure for PTSD

NCT03485391
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Anxiety Disorders, Mental Disorder, Traumatic Disorder
Interventions
Prolonged Exposure
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2024 · Synced Sep 10, 2026, 4:22 PM EDT
Active, not recruiting Phase 1 Interventional

A Study of Psilocybin for PTSD

NCT06407635
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Psilocybin, Trauma-focused psychotherapy, Standard psychological support
Drug · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Not yet recruiting Not applicable Interventional

Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress

NCT07483333
View directory record Official record
Conditions
Trauma Exposure, Trauma, Trauma and Stressor Related Disorder, Mental Health Functioning, Chronic Medical Conditions, Chronic Medical Condition, Chronic Medical Illness, Posttraumatic Stress Disorder PTSD, Posttraumatic Stress Disorders, Posttraumatic Stress Symptoms, Posttraumatic Stress
Interventions
Structured Psychotherapy for Adolescents Responding to Chronic Stress - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Group, Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents - Individual, Structured Psychotherapy for Adolescents Responding to Chronic Stress - Individual
Behavioral
Lead sponsor
Anthony Vesco
Other
Eligibility
8 Years to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel

NCT01049516
View directory record Official record
Conditions
Posttraumatic Stress Disorders, Combat Disorders
Interventions
Prolonged Exposure Therapy - Massed, Prolonged Exposure Therapy - Spaced, Minimal Contact Control, Present-Centered Therapy
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years
Enrollment
366 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Killeen, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Nov 26, 2018 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Phase 2 Interventional Results available

Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth

NCT01157416
View directory record Official record
Conditions
Posttraumatic Stress Disorders, PTSD
Interventions
D-cycloserine, Placebo pill, CBT
Drug · Behavioral
Lead sponsor
Tulane University School of Medicine
Other
Eligibility
7 Years to 12 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Brain Response to Treatment for Pediatric PTSD

NCT01806701
View directory record Official record
Conditions
Emotions, Memory Deficits, Post-traumatic Syndrome
Interventions
Trauma-focused cognitive behavioral therapy
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
9 Years to 17 Years
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 12, 2016 · Synced Sep 10, 2026, 4:22 PM EDT
Active, not recruiting Not applicable Interventional

Open Pilot Trial of Adapted Cognitive Processing Therapy for Comorbid PTSD and Opioid Use Disorder

NCT06872164
View directory record Official record
Conditions
Posttraumatic Stress Disorder (PTSD), Opioid Use Disorder
Interventions
Cognitive Processing Therapy
Behavioral
Lead sponsor
The City College of New York
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Somatic Yoga and Meditation for Cancer Survivors With Pain From Neuropathy

NCT03786055
View directory record Official record
Conditions
Cancer Survivor, Pain, Chemotherapy Induced Peripheral Neuropathy, Function, Fall Risk, Balance, Quality of Life
Interventions
Somatic Yoga and Meditation (SYM)
Behavioral
Lead sponsor
Stockton University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
2
States / cities
Atlantic City, New Jersey • Pomona, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional

Outcomes After Spinal Cord Injury (OASIS)

NCT03624218
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Spinal Cord Injuries
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 10, 2026, 4:22 PM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness of Two Treatments for Veterans With PTSD

NCT02586064
View directory record Official record
Conditions
Posttraumatic Stress Disorder
Interventions
Interpersonal Therapy for PTSD, Prolonged Exposure
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
2
States / cities
New Orleans, Louisiana • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 6, 2021 · Synced Sep 10, 2026, 4:22 PM EDT
Not yet recruiting Not applicable Interventional

Recovery-oriented Group Therapy for Veteran Men With Military Sexual Trauma

NCT06741202
View directory record Official record
Conditions
Sexual Trauma
Interventions
Men's MST Group, Present-Centered Group Therapy
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Male only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 10, 2026, 4:22 PM EDT