Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 7, 2026, 9:37 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2473–2496 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Depression
Interventions: 6(S)-5-MTHF(Deplin), Placebo; Other
Lead sponsor: George I. Papakostas; Other
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 6
States / cities: San Diego, California • Chicago, Illinois • Boston, Massachusetts + 3 more

Conditions: Bipolar Disorder Depression
Interventions: ABX-002; Drug
Lead sponsor: Autobahn Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 14
States / cities: Walnut Creek, California • Cromwell, Connecticut • Hartford, Connecticut + 10 more

Conditions: Depression, Other Diagnoses, Comorbidities, and Complications
Interventions: No treatment; Other
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 10 Years to 89 Years
Enrollment: 447 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Depression
Interventions: Not listed
Lead sponsor: Center for Psychological Research, Madison, WI; Other
Eligibility: 18 Years to 80 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: Boston, Massachusetts

Conditions: Cellulite
Interventions: cyrolipolysis (CoolSculpting device), subcision; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Depressive Disorder, Major
Interventions: BI 1358894, Placebo, Quetiapine; Drug
Lead sponsor: Boehringer Ingelheim; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 389 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 29
States / cities: Birmingham, Alabama • Garden Grove, California • Long Beach, California + 23 more

Conditions: Alcohol Dependence
Interventions: LPA+Fitbit, HEC; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Acceptance and Commitment Therapy
Interventions: Acceptance and Commitment Therapy; Other
Lead sponsor: Southern Methodist University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Neurological Disorder
Interventions: Psychosocial Skills-Based Intervention; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder, Post Traumatic Stress Disorder
Interventions: Positive Processes and Transition to Health (PATH); Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 3
States / cities: Newark, Delaware • Cleveland, Ohio • Seattle, Washington

Conditions: Maternal Psychological Distress, Prenatal Stress, Infant Development, Functional Neuroimaging, Pregnancy Related
Interventions: Mindfulness Based Cognitive Therapy; Behavioral
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 3 Days to 45 Years · Female only
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Major Depressive Disorder
Interventions: Not listed
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 70 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Seasonal Affective Disorder
Interventions: Cognitive-Behavioral Therapy (CBT-SAD), Light Therapy; Behavioral · Other
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 141 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Depression
Interventions: Interpersonal Psychotherapy for Adolescents, Treatment as usual; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 12 Years to 18 Years
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Treatment-resistant Depression
Interventions: Esketamine (Intranasal Spray), Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant), Sertraline (Oral Antidepressant), Venlafaxine Extended Release (XR) (Oral Antidepressant); Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 802 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 16
States / cities: New Haven, Connecticut • Miami, Florida • Marietta, Georgia + 13 more

Conditions: Arthrogryposis, Craniofacial Abnormalities, Posttraumatic Stress Disorder, Depressive Disorder
Interventions: PTSD Checklist-Specific, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale, Functional Enquiry Form, Strength, Joint ROM, Girth and Length Measurements, Study Physical Examination, PTSD, Depression, and FSS-Focused Examination, Freeman-Sheldon Specific Quality of Life Survey, Lactate, Glucose, and Adenosine Triphosphate Blood Levels; Other
Lead sponsor: Freeman-Sheldon Research Group, Inc.; Other
Eligibility: Not listed
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Buckhannon, West Virginia

Conditions: Parkinson's Disease
Interventions: Deep Brain Stimulation; Procedure
Lead sponsor: Vanderbilt University; Other
Eligibility: 50 Years to 85 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Pelvic Floor Disorder, Loneliness, Postpartum, Mental Health, Depression, Peritraumatic Distress, Women, Artificial Intelligence (AI), Chatbot
Interventions: Generative artificial intelligence (genAI) postpartum chatbot, Standard of Care (SOC); Other
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older · Female only
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Depression
Interventions: Cognitive Training, Sham Training; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: MRI scan, Behavioral testing; Other · Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 260 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 4
States / cities: Boston, Massachusetts • Providence, Rhode Island

Conditions: Major Depressive Disorder
Interventions: AGN-241751, Placebo; Drug
Lead sponsor: Syndeio Biosciences, Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 226 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 5
States / cities: Phoenix, Arizona • Garden Grove, California • Atlanta, Georgia + 2 more

Conditions: Major Depressive Disorder
Interventions: Open-label Placebo; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder (MDD)
Interventions: Rejoyn, Cognitive Behavioral Therapy (CBT) exercises; Device · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 22 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Greenwich, Connecticut • New Haven, Connecticut

Conditions: Depression
Interventions: Cognitive behavioral therapy (CBT), Drug therapy; Behavioral · Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 11 Years to 18 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Dallas, Texas

Search by objective public record fields.

Study of 6(S)-5-MTHF Among Selective Serotonin Reuptake Inhibitor-Resistant Outpatients With Major Depressive Disorder

Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Disorder in Adults

UTSW Depression Cohort: A Longitudinal Study of Depression

Vocal Acoustic Biomarkers in Depression

Cyrolipolysis vs Cyrolipolysis and Subcision for Cellulite

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women

ACT for High-risk Pregnancy

Preventing Chronic Depression and PTSD in Stroke Patients Admitted to the Neuroscience Intensive Care Unit (NICU) and Their Family Caregivers

Positive Processes and Transition to Health

Roo Study on Mom and Baby Well-Being

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy

Strong Connections

A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression

Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions

Effect of Deep Brain Stimulation on Depression and Quality of Life in Parkinson's Patients

Postpartum Education Via Artificial Intelligence for Recovery and Loneliness: A Randomized Controlled Trial

Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

Brain Connectivity in Depression

Zelquistinel in the Treatment of Adults With Major Depressive Disorder

Pilot Study of Open-label Placebo to Treat Major Depressive Disorder

REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness

Cognitive Behavioral Therapy for Depression Relapse Prevention in Children and Adolescents