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ClinicalTrials.gov public records Last synced Nov 8, 2026, 12:44 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2665–2688 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Major Depressive Disorder
Interventions: Tocilizumab; Drug
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 70 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: New York, New York

Conditions: Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia, Attention Deficit Hyperactivity Disorder, Borderline Personality Disorder, Substance Use Disorders
Interventions: Transcranial Direct Current Stimulation; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 600 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Post Partum Depression
Interventions: Bright Light Therapy, Dim Light Therapy; Device
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years and older · Female only
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Major Depressive Disorder
Interventions: Transcranial Photobiomodulator, Sham; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 3
States / cities: Charlestown, Massachusetts • New York, New York • Orangeburg, New York

Conditions: Major Depressive Disorder, Irritability
Interventions: Brexpiprazole; Drug
Lead sponsor: H. Lundbeck A/S; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2013
U.S. locations: 15
States / cities: Tucson, Arizona • Glendale, California • Oakland, California + 12 more

Conditions: Panic Disorder
Interventions: Paroxetine, Clozapine; Drug
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Not listed
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Bipolar Disorder
Interventions: Continuous Theta Burst Stimulation (cTBS), Sham Continuous Theta Burst Stimulation (Sham cTBS); Device
Lead sponsor: Mary Phillips, MD MD (Cantab); Other
Eligibility: 18 Years to 35 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depression
Interventions: Guideline-Based Medical Management, Motivational Interviewing for Depression; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years and older
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Cognitive Behavioral Therapy, Therapy
Interventions: LyssnCBT; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 448 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: POTS - Postural Orthostatic Tachycardia Syndrome
Interventions: Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events, Will wear an activity monitor, Periodic 24-hour urine sodium check, A fMRI scan, A bedside tilt test will be performed, IV placed to collect blood samples, Stool Sample; Behavioral · Device · Other + 1 more
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 12 Years to 21 Years · Female only
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Maternal Care Patterns
Interventions: Mom-Net, Coach-facilitated Treatment as Usual; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: Female only
Enrollment: 266 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Eugene, Oregon

Conditions: Depression
Interventions: Hatha Yoga; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 13 Years to 18 Years
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Parkinson's Disease
Interventions: High-Frequency Repetitive Transcranial Magnetic Stimulation, Sham Repetitive Transcranial Magnetic Stimulation; Device
Lead sponsor: University of Florida; Other
Eligibility: 30 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Depression
Interventions: Apimostinel Infusion, Intravenous, Cognitive Training, Sham Training, Isotonic Solution, Intravenous; Drug · Behavioral
Lead sponsor: Rebecca Price; Other
Eligibility: 18 Years to 60 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depression, Temporal Lobe Epilepsy
Interventions: escitalopram, placebo; Drug
Lead sponsor: Conrad, Erich J., M.D.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Major Depressive Disorder (MDD)
Interventions: Ketamine only; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 25 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Treatment Resistant Depression (TRD), Chronic Pain
Interventions: Ketamine hydrochloride injection; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Epilepsy, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression
Interventions: TIME; Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depression Severe
Interventions: INTRACALVARIAL PREFRONTAL CORTICAL STIMULATION (IpCS) IN SEVERE TREATMENT-RESISTANT DEPRESSION; Device
Lead sponsor: Inner Cosmos Inc; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: Boston, Massachusetts • St Louis, Missouri

Conditions: Depression
Interventions: Limbix Spark; Other
Lead sponsor: Limbix Health, Inc.; Industry
Eligibility: 12 Years to 21 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Perinatal Depression
Interventions: Mothers and Babies Online (eMB); Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 16 Years and older · Female only
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 6
States / cities: Chicago, Illinois • Joliet, Illinois • Chariton, Iowa + 3 more

Conditions: Traumatic Brain Injury, Recidivism
Interventions: Reentry Continuum for Brain Injury (RCBI); Behavioral
Lead sponsor: Rehabilitation Hospital of Indiana; Other
Eligibility: 18 Years and older · Male only
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Greencastle, Indiana

Conditions: Depression, Depression in Old Age
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 60 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Respiratory Complications, Opioid Induced Respiratory Depression, Postoperative Respiratory Complications
Interventions: Respiratory volume monitoring; Diagnostic Test
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Detroit, Michigan

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Neutralizing Interleukin (IL)-6

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

A Wearable Morning Light Treatment for Postpartum Depression

Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression

Study of Brexpiprazole as Adjunctive Treatment of Irritability in Patients With Major Depressive Disorder and an Inadequate Response to Antidepressant Therapy

Evaluation of Clonazepam and Paroxetine for Panic Disorder With Depression

Effects of Theta Burst Stimulation on the Brain, Behavior, and Clinical Symptoms in Adults With Bipolar Disorder

Motivational Interviews for Depression in Primary Care

AI-Based Fidelity Feedback to Enhance CBT

Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?

Depressed Mothers in Rural Areas: Web-Facilitated Cognitive Behavioral Treatment

Treatments for Improving Mood in Depressed Teens-2

Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Apathy in Parkinson's Disease

Apimostinel + Automated Neurocognitive Training for Depression

Escitalopram Treatment of Major Depression in Patients With Temporal Lobe Epilepsy

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

Targeted Self-Management for Epilepsy and Serious Mental Illness (TIME)

Brain Stimulation for Severe Depression

A Mobile and Virtual Reality Intervention for Adolescent Depression

Pilot Study of Mothers and Babies Online in Home Visiting

Re-entry Continuum for Brain Injury

Technology-enabled Task-sharing for Depression in Primary Care

Timing of Opioid Administration and Postoperative Respiratory Depression.