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ClinicalTrials.gov public records Last synced Oct 15, 2026, 9:23 PM EDT

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Showing 529–552 of 3,100 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tailored Health Self-Management Interventions for Highly Distressed Family Caregivers

NCT03023332
View directory record Official record
Conditions
Distress, Caregiver
Interventions
Resourcefulness Training, Biofeedback training, Bipolar Education
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 120 Years
Enrollment
310 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 15, 2023 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interpersonal Therapy-Based Treatment to Prevent Postpartum Depression in Adolescent Mothers

NCT01482832
View directory record Official record
Conditions
Postpartum Depression
Interventions
Interpersonal therapy-based treatment
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
12 Years to 19 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Implementation Science Approach to Enhancing Depression Treatment in Collaborative Depression Care Settings ( DepCare )

NCT05085886
View directory record Official record
Conditions
Depressive Symptoms
Interventions
DepCare, Enhanced Usual Care
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
605 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 14, 2025 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional Results available

The PACE/PACENET Behavioral Health Laboratory Project

NCT02440594
View directory record Official record
Conditions
Depression
Interventions
Enhanced BHL Program Services, Standard BHL Program Services
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
65 Years and older
Enrollment
2,432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 3 Interventional

Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression

NCT01685294
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Group IPT for Depression + TAU
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
5
States / cities
Bridgewater, Massachusetts • Framingham, Massachusetts • Norfolk, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Behavioral Activation Teletherapy to Increase Physical Activity

NCT04990401
View directory record Official record
Conditions
Depression, Depressive Disorder, Depressive Symptoms, Depressive Episode
Interventions
Behavioral Activation Teletherapy
Behavioral
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 64 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Depression Prevention for Pregnant Women on Public Assistance

NCT00601757
View directory record Official record
Conditions
Depression, Postpartum, Depression
Interventions
The Postpartum Prevention Program (PPP), Enhanced care as usual (ECU)
Behavioral
Lead sponsor
Women and Infants Hospital of Rhode Island
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
3
States / cities
Providence, Rhode Island • Woonsocket, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 31, 2014 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Results available

Ketamine Infusion for Adolescent Depression and Anxiety

NCT02579928
View directory record Official record
Conditions
Major Depressive Disorder, Anxiety Disorder
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Yale University
Other
Eligibility
13 Years to 17 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 14, 2020 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 2 Interventional Results available

Lexapro and Pramipexole and to Treat Major Depression

NCT00086307
View directory record Official record
Conditions
Major Depression
Interventions
Pramipexole, Escitalopram
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 28, 2013 · Synced Oct 15, 2026, 9:23 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression

NCT05966532
View directory record Official record
Conditions
Major Depressive Disorder (MDD), Healthy Adult Volunteer
Interventions
Hot Cognitive Task, Cold cognitive tasks, Structural magnetic resonance imaging (sMRI), Magnetoencephalography imaging (MEG), four self-report forms per the requirement of the NIH Common Data Elements project, Four self-report measures to assess interpersonal functioning, Clinical assessments, ATHF
Behavioral · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 80 Years
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Arlington, Texas • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional

The Use Of L-Methylfolate As A Treatment For Depression

NCT02133898
View directory record Official record
Conditions
Depression
Interventions
L-methylfolate
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 7, 2023 · Synced Oct 15, 2026, 9:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

In Vivo Imaging of Therapeutic Electric Current Flow

NCT02453763
View directory record Official record
Conditions
Parkinson Disease, Epilepsy, Alzheimer's Disease, Stroke, Autism, Depression, Schizophrenia
Interventions
Transcranial direct current stimulation, MRI
Device · Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 30 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 1 Interventional

Cognitive Behavioral Therapy Delivered Over the Internet for Women With Postpartum Depression

NCT00942721
View directory record Official record
Conditions
Postpartum Depression
Interventions
Web-based CBT for PPD
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Iowa City, Iowa • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 25, 2013 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interpersonal Psychotherapy for Adolescent Girls

NCT01534377
View directory record Official record
Conditions
Depression
Interventions
Interpersonal Psychotherapy for Adolescents, Enhanced Care
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
13 Years to 15 Years · Female only
Enrollment
328 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2018 · Synced Oct 15, 2026, 9:23 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)

NCT01369030
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Deplin®
Other
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
554 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
2
States / cities
Greensboro, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 3, 2014 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 2 Interventional

Nitrous Oxide for the Treatment of Major Depressive Disorder

NCT03869736
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
Nitrous Oxide, Placebo
Drug
Lead sponsor
Bayside Health
Government
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional

Emotional Awareness and SElf-regulation for Depression in Patients With Hypertension (EASE) Study

NCT03013907
View directory record Official record
Conditions
Hypertension
Interventions
UPLIFT, Usual care
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2019 · Synced Oct 15, 2026, 9:23 PM EDT
Not yet recruiting Not applicable Interventional

Health-Related Social Needs Food Boxes Delivery Program

NCT07643909
View directory record Official record
Conditions
Food Insecurity
Interventions
Monthly food staples and fresh produce, Standard of care
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Building Caregiver Skills Using a Simulation-based Intervention for Care of Head and Neck Cancer

NCT02577237
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
In-person education sessions, NCI Booklet, Survey, Interview
Behavioral · Other
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 11, 2019 · Synced Oct 15, 2026, 9:23 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

The Effect of Adiposity on Muscle and Microvascular Function in HFpEF

NCT06930495
View directory record Official record
Conditions
Heart Failure With Preserved Ejection Fraction (HFPEF)
Interventions
Weight loss SOC Treatment with second generation anti-diabetic medications
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
95 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 15, 2026, 9:23 PM EDT
Terminated Phase 2 Interventional Results available

The UTHealth Ketamine Project

NCT02882711
View directory record Official record
Conditions
Treatment Resistant Depression, Major Depressive Disorder, Bipolar Disorder
Interventions
Ketamine
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 24, 2020 · Synced Oct 15, 2026, 9:23 PM EDT
Recruiting Phase 2 Interventional

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

NCT07002034
View directory record Official record
Conditions
Adjustment Disorder
Interventions
RE104 for Injection
Drug
Lead sponsor
Reunion Neuroscience Inc
Industry
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
32
States / cities
Birmingham, Alabama • Tucson, Arizona • San Diego, California + 28 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 2 Interventional

Efficacy and Safety of GLYX-13 in Subjects With Inadequate/Partial Response to Antidepressants

NCT01684163
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
GLYX-13 5 mg/kg, GLYX-13 10 mg/kg, Placebo
Drug
Lead sponsor
Naurex, Inc, an affiliate of Allergan plc
Industry
Eligibility
18 Years to 75 Years
Enrollment
369 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
26
States / cities
Birmingham, Alabama • Encino, California • Los Alamitos, California + 21 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Oct 15, 2026, 9:23 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause"

NCT03740009
View directory record Official record
Conditions
Perimenopausal Disorder, Depression
Interventions
Bazedoxifene/Conjugated Estrogen
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
44 Years to 55 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 10, 2022 · Synced Oct 15, 2026, 9:23 PM EDT