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ClinicalTrials.gov public records Last synced Oct 16, 2026, 2:51 AM EDT

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Showing 625–648 of 3,100 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Completed Not applicable Interventional

Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women

NCT00572520
View directory record Official record
Conditions
Depression, Obesity
Interventions
Weight loss treatment, Behavior therapy for depression, Health education counseling
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
161 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 5, 2018 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional

PRISM Neurofeedback Training for MDD Anhedonic Patients

NCT05869708
View directory record Official record
Conditions
Depression, Anhedonia
Interventions
Active RS-EFP, Sham RS-EFP
Device
Lead sponsor
GrayMatters Health Ltd.
Industry
Eligibility
22 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 5, 2025 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Phase 2 Interventional Results available

Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome

NCT00149825
View directory record Official record
Conditions
Major Depressive Disorder, Insomnia
Interventions
Escitalopram, CBTI, CTRL
Drug · Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 16, 2026, 2:51 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease

NCT00208117
View directory record Official record
Conditions
Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
Interventions
Sertraline (Zoloft), Simvastatin (Zocor)
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 31, 2012 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Phase 2 Interventional

Brief CBT for Anxiety and Advanced Cancer

NCT00706290
View directory record Official record
Conditions
Anxiety, Depression, Unspecified Adult Solid Tumor, Protocol Specific, Cancer, Cognitive Behavioral Therapy
Interventions
Brief Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 6, 2014 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Phase 4 Interventional Results available

A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder

NCT04041284
View directory record Official record
Conditions
Migraine, Major Depressive Disorder
Interventions
Fremanezumab, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
353 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
17
States / cities
Little Rock, Arkansas • San Diego, California • Denver, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional

Care Coordination Approaches to Learning Lupus Self-management

NCT04400240
View directory record Official record
Conditions
Systemic Lupus Erythematosus
Interventions
CALLS
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2020 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Results available

Behavioral Activation Therapy for Rural Veterans With Diabetes and Depression

NCT01572389
View directory record Official record
Conditions
Diabetes Mellitus, Depression
Interventions
Healthy Outcomes through Patient Empowerment (HOPE), Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2017 · Synced Oct 16, 2026, 2:51 AM EDT
Recruiting Not applicable Interventional

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

NCT04877197
View directory record Official record
Conditions
Depression, Cardiovascular Diseases
Interventions
BA-HT, Standard Care
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 16, 2026, 2:51 AM EDT
Terminated Phase 2 Interventional

Efficacy and Safety of DOV 21,947 in the Treatment of Major Depressive Disorder

NCT00659347
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
DOV 21, 947, Placebo
Drug
Lead sponsor
DOV Pharmaceutical, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
10
States / cities
Norwich, Connecticut • Springfield, Massachusetts • Cherry Hill, New Jersey + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 5, 2008 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sensation Awareness Focused Training for Spouses

NCT03129204
View directory record Official record
Conditions
Post Intensive Care Syndrome, Anxiety, Depression, Posttraumatic Stress Disorder, Sleep Deprivation
Interventions
SAF-T
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional

Treatment for Depressed, Obese Individuals at Risk for Cardiovascular Disease (CVD)

NCT01692574
View directory record Official record
Conditions
Obesity, Major Depressive Disorder, Dysthymic Disorder, Cardiovascular Disease
Interventions
Behavior Modification for Weight Loss, Alternative Approach to Weight Loss, Cognitive-Behavior Therapy for Depression, Depression Support and Education
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 70 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 22, 2016 · Synced Oct 16, 2026, 2:51 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Reducing Depressive Symptoms During HCV Therapy: A Randomized Study

NCT00495768
View directory record Official record
Conditions
Hepatitis C, Depression
Interventions
Group Training
Behavioral
Lead sponsor
South Texas Veterans Health Care System
Federal
Eligibility
25 Years to 68 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2007 · Synced Oct 16, 2026, 2:51 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Improving Behavioral Health for Caregivers and Children After Pediatric Injury

NCT06856057
View directory record Official record
Conditions
Quality of Life, PTSD, Depression Not Otherwise Specified, Child Externalizing Behavior
Interventions
Caregivers' Aid to Accelerate Recovery after pediatric Emergencies (CAARE)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
348 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
4
States / cities
Los Angeles, California • Lexington, Kentucky • Ann Arbor, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 16, 2026, 2:51 AM EDT
Completed No phase listed Observational

Mental and Cognitive Health and Physical Activity in the Perioperative Breast Cancer Setting

NCT06595901
View directory record Official record
Conditions
Breast Cancer, Breast Neoplasms, Cancer, Breast, Cancer of the Breast
Interventions
Actigraph, Questionnaires, BrainBaseline application, Semi-structured interviews
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 16, 2026, 2:51 AM EDT
Recruiting Phase 1Phase 2 Interventional

Accelerated rTMS vs. Sham for Stroke Apathy

NCT07113067
View directory record Official record
Conditions
Apathy, Stroke, Stroke Sequelae, Stroke/Brain Attack, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Motivation, Abulia
Interventions
MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active), MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Sham), Brainsight Neuronavigation System
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 16, 2026, 2:51 AM EDT
Recruiting Not applicable Interventional

Nutritional Intervention for College Students With Depression

NCT07490782
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Mediterranean Diet, Time-Restricted Eating
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Results available

Cranial Electrotherapy Stimulation for the Treatment of Major Depressive Disorder in Adults

NCT05384041
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Fisher Wallace Cranial Electrotherapy Stimulator (Active Device), Fisher Wallace Cranial Electrotherapy Stimulator (Placebo Device)
Device
Lead sponsor
Fisher Wallace Laboratories
Industry
Eligibility
21 Years to 65 Years
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Treating Comorbid Depression During Care Transitions Using Relational Agents

NCT02845102
View directory record Official record
Conditions
Chronic Illness, Chronic Pain, Depression, Comorbid Depression
Interventions
Pre-Post Feasibility
Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 1, 2017 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Telephone Assessment and Skill-Building Intervention for Stroke Caregivers

NCT01275495
View directory record Official record
Conditions
Stroke, Family Caregivers
Interventions
Telephone Assessment and Skill-Building Kit (TASK II), Information, Support, and Referral (ISR)
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
254 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 31, 2015 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Phase 1Phase 2 Interventional

Reducing Health Risk Behavior and Improving Health in Adolescents With Depression

NCT00461539
View directory record Official record
Conditions
Depression, Adolescent Health
Interventions
Treatment as usual, Behavioral health intervention
Other · Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 18 Years
Enrollment
217 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2022 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

We The Village Family Support Study

NCT04250077
View directory record Official record
Conditions
Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
Interventions
Community Reinforcement And Family Training (CRAFT), We The Village Peer Community Forum
Behavioral
Lead sponsor
We The Village, Inc.
Other
Eligibility
19 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Oct 16, 2026, 2:51 AM EDT
Completed Not applicable Interventional Results available

One-Day Acceptance and Commitment Training Intervention in Primary Care Patients

NCT01879800
View directory record Official record
Conditions
Mood Disorders, Hypertension, Diabetes, Hypercholesterolemia
Interventions
Acceptance and Commitment Therapy plus Illness Management
Behavioral
Lead sponsor
Lilian N. Dindo
Other
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 25, 2017 · Synced Oct 16, 2026, 2:51 AM EDT
Suspended Not applicable Interventional

Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

NCT05719909
View directory record Official record
Conditions
Depression
Interventions
Cognitive Training, Sham Training
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Oct 16, 2026, 2:51 AM EDT