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ClinicalTrials.gov public records Last synced Oct 25, 2026, 6:21 AM EDT

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Showing 1465–1488 of 3,102 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Completed Phase 4 Interventional Results available

Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty

NCT03271151
View directory record Official record
Conditions
Joint Disease, Pain, Acute, Pain, Chronic
Interventions
Cymbalta, Placebo
Drug · Other
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
25 Years to 75 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 27, 2024 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional

Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression

NCT06730841
View directory record Official record
Conditions
Treatment Resistant Depression, Major Depressive Disorder
Interventions
Dose-Optimized and Spaced Transcranial Direct Current Stimulation, Spaced Transcranial Direct Current Stimulation, Sham Transcranial Direct Current Stimulation
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 85 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Piloting a Novel, Mobile Cognitive Training Tool for Patients With Major Depressive Disorder (MDD)

NCT02922556
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
Other
Lead sponsor
Posit Science Corporation
Industry
Eligibility
18 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional

Moderate Physical Activity in Helping Patients Recover Physically and Emotionally From Stage II Or Stage III Colorectal Cancer

NCT00373022
View directory record Official record
Conditions
Anxiety Disorder, Colorectal Cancer, Depression, Psychosocial Effects of Cancer and Its Treatment
Interventions
exercise intervention, flow cytometry, laboratory biomarker analysis, management of therapy complications, psychosocial assessment and care, quality-of-life assessment
Behavioral · Other · Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 27, 2010 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional

Use of Psychologist-administered Cognitive Behavioral Therapy (CBT) or Self-administered CBT for the Treatment of Anxiety and/or Depression in Inflammatory Bowel Disease (IBD)

NCT05377840
View directory record Official record
Conditions
Crohn Disease, Ulcerative Colitis (UC)
Interventions
Psychologist-administered Cognitive Behavioral Therapy, Self-Administered Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional

Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence

NCT01714050
View directory record Official record
Conditions
Seasonal Affective Disorder (SAD), Winter Depression, Major Depressive Disorder, Recurrent, With Seasonal Pattern
Interventions
Cognitive-Behavioral Therapy (CBT), Light Therapy (LT)
Behavioral · Device
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 25, 2026, 6:21 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app

NCT07032350
View directory record Official record
Conditions
Care Giving Burden, Dementia, Chronic Pain, Pain Management, Palliative Care
Interventions
Web-based pain management support tool, Usual Pain Management Care
Other · Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 100 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 29, 2025 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Results available

Depression Outpatient Cardiology Screening Study

NCT01552889
View directory record Official record
Conditions
Depression, Coronary Heart Disease
Interventions
Collaborative Care
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 27, 2017 · Synced Oct 25, 2026, 6:21 AM EDT
Completed No phase listed Observational

Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics

NCT03947099
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, Anxiety Disorders
Interventions
Ketamine Hydrochloride
Drug
Lead sponsor
Klarisana Physician Services PLLC
Industry
Eligibility
18 Years to 75 Years
Enrollment
7 participants
Timeline
2019 – 2021
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 25, 2026, 6:21 AM EDT
Not listed Not applicable Interventional

Transcranial Magnetic Stimulation vs Theta Burst Stimulation in Major Depressive Disorder

NCT04497350
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Transcranial Magnetic Stimulation, Theta Burst Stimulation
Device
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional

Mindfulness-Based Intervention for Teens With Autism Spectrum Disorder and Their Caregivers

NCT05685589
View directory record Official record
Conditions
Autism Spectrum Disorder
Interventions
MINDful TIME
Behavioral
Lead sponsor
Southwest Autism Research & Resource Center
Other
Eligibility
13 Years to 18 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 17, 2024 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Results available

Comparing Group Therapies for Veterans With Depression and PTSD

NCT03979040
View directory record Official record
Conditions
Major Depressive Disorder, Posttraumatic Stress Disorder
Interventions
Group Transdiagnostic Behavior Therapy, Group Disorder-Specific Therapy (G-DSTs)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
294 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Results available

Hepatitis C Translating Initiatives for Depression Into Effective Solutions

NCT01143896
View directory record Official record
Conditions
Hepatitis C, Depression
Interventions
Depression collaborative care model
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
309 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
4
States / cities
Little Rock, Arkansas • West Los Angeles, California • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Oct 25, 2026, 6:21 AM EDT
Terminated Phase 2Phase 3 Interventional

SAINT for MDD in an Inpatient Setting Follow-on

NCT06462820
View directory record Official record
Conditions
Major Depressive Disorder, Major Depressive Episode, Suicidal Ideation
Interventions
Active SAINT Stimulation, Sham SAINT Stimulation
Device
Lead sponsor
Magnus Medical
Industry
Eligibility
18 Years to 75 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
Iowa City, Iowa • Manhattan, New York • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Results available

Positive Valence System Enhancement Treatment for Anxiety and Depression: Clinical Efficacy and Neural Changes

NCT02330627
View directory record Official record
Conditions
Anxiety Disorders and Symptoms, Depression
Interventions
Positive Valence System Treatment
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 55 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Nov 8, 2021 · Synced Oct 25, 2026, 6:21 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression

NCT01579942
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Oct 25, 2026, 6:21 AM EDT
Recruiting Not applicable Interventional

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

NCT06298721
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy, Surgery
Interventions
Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Phase 2 Interventional

Treatment of Mid-Life-Related Mood Disorders

NCT00001487
View directory record Official record
Conditions
Depressive Disorder, Mood Disorder
Interventions
Dehydroepiandrosterone
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Phase 2 Interventional

Efficacy and Safety of Fixed Doses of BMS 820836 in the Treatment of Patients With Treatment Resistant Major Depression

NCT01369095
View directory record Official record
Conditions
Depression
Interventions
Duloxetine, Escitalopram, BMS-820836 Placebo, BMS-820836
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 65 Years
Enrollment
976 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
48
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Chino, California + 41 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2015 · Synced Oct 25, 2026, 6:21 AM EDT
Active, not recruiting Not applicable Interventional

Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals

NCT01075672
View directory record Official record
Conditions
Obsessive Compulsive Disorder, Body Dysmorphic Disorder, Tourette Syndrome, Trichotillomania, Panic Disorder, Social Phobia, Generalized Anxiety Disorder, Depression, Post-Traumatic Stress Disorder, Attention Deficit Hyperactivity Disorder, Eating Disorder, Specific Phobia, General Medical Condition
Interventions
Cognitive behavioral therapy (CBT)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 25, 2026, 6:21 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Mindfulness Based Cognitive Therapy (MBCT) Resiliency Program for Critical Care Nurses

NCT03132220
View directory record Official record
Conditions
Burn-Out Syndrome, Work-Related Stress Disorder
Interventions
Mindfulness-Based Cognitive Therapy, Book Club Active Control Intervention
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
131 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 9, 2019 · Synced Oct 25, 2026, 6:21 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Reducing Depressive Symptoms During HCV Therapy: A Randomized Study

NCT00495768
View directory record Official record
Conditions
Hepatitis C, Depression
Interventions
Group Training
Behavioral
Lead sponsor
South Texas Veterans Health Care System
Federal
Eligibility
25 Years to 68 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2007 · Synced Oct 25, 2026, 6:21 AM EDT
Recruiting Not applicable Interventional

Accelerated TMS for Perinatal Depression

NCT06968390
View directory record Official record
Conditions
Perinatal Depression, Post Partum Depression, Major Depressive Disorder
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 25, 2026, 6:21 AM EDT
Recruiting Not applicable Interventional

Nutritional Intervention for College Students With Depression

NCT07490782
View directory record Official record
Conditions
Depression - Major Depressive Disorder
Interventions
Mediterranean Diet, Time-Restricted Eating
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 25, 2026, 6:21 AM EDT