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ClinicalTrials.gov public records Last synced Oct 8, 2026, 7:26 AM EDT

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Showing 169–192 of 3,097 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Treatment of depression Clear all
Completed Phase 2 Interventional Results available

A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression

NCT04521478
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
BI 1358894, Placebo, Quetiapine
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 65 Years
Enrollment
389 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
29
States / cities
Birmingham, Alabama • Garden Grove, California • Long Beach, California + 23 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2025 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

Effective Care Management of Depressed Diabetes Patients (The Positive Steps Study)

NCT01106885
View directory record Official record
Conditions
Diabetes, Depression
Interventions
Medication Care Management (MCM), Cognitive-Behavioral Therapy (CBT)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years to 80 Years
Enrollment
339 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
3
States / cities
Ann Arbor, Michigan • Grand Blanc, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 4 Interventional Results available

Inflammation-related Alterations in Neurocircuitry: Reversal With Levodopa

NCT02513485
View directory record Official record
Conditions
Depression
Interventions
Levodopa+carbidopa, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 19, 2022 · Synced Oct 8, 2026, 7:26 AM EDT
Enrolling by invitation Not applicable Interventional

The BEET Diabetes Feasibility Trial

NCT06247514
View directory record Official record
Conditions
Disordered Eating Behaviors
Interventions
The BEET Diabetes Program, Cognitive Behavioral Therapy Guided Self-Help
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Aurora, Colorado • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 11, 2025 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 1Phase 2 Interventional

Online Stress Management and Coping Skills Training for Women With Breast Cancer

NCT01335152
View directory record Official record
Conditions
Breast Cancer
Interventions
Coping with Breast Cancer web-based workbook
Behavioral
Lead sponsor
Talaria, Inc
Industry
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 7, 2014 · Synced Oct 8, 2026, 7:26 AM EDT
Terminated Phase 2 Interventional Results available

Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features

NCT00585585
View directory record Official record
Conditions
Recurrent Major Depressive Disorder With Atypical Features
Interventions
betahistine dihydrochloride
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies

NCT06432959
View directory record Official record
Conditions
Depression, Borderline Personality Disorder, Emotion Regulation
Interventions
Psychotherapy, Positive Affect Promoting Activities, Psychotherapy
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 22, 2025 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression

NCT02422186
View directory record Official record
Conditions
Depressive Disorder, Treatment-Resistant
Interventions
Esketamine, Placebo, Duloxetine (Oral Antidepressant), Escitalopram (Oral Antidepressant), Sertraline (Oral Antidepressant), Venlafaxine Extended Release (XR) (New Antidepressant)
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
65 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
15
States / cities
San Diego, California • New Haven, Connecticut • Miami, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 8, 2026, 7:26 AM EDT
Not listed Phase 1 Interventional

Treatment of Conduct Problems and Depression

NCT01267773
View directory record Official record
Conditions
Depression, Oppositional Defiant Disorder, Conduct Disorder
Interventions
Integrated Treatment
Behavioral
Lead sponsor
Rhode Island Hospital
Other
Eligibility
8 Years to 14 Years
Enrollment
30 participants
Timeline
2010 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 21, 2013 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)

NCT05356364
View directory record Official record
Conditions
Insomnia, Depression
Interventions
Cognitive Behavioral Therapy for Insomnia (CBTI), Perinatal Understanding of Mindful Awareness for Sleep (PUMAS)
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Remote Bimanual Virtual Rehabilitation Post CVD

NCT04713384
View directory record Official record
Conditions
Stroke Sequelae, Cognitive Impairment, Depression
Interventions
Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
Device
Lead sponsor
Grigore Burdea
Industry
Eligibility
48 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 8, 2026, 7:26 AM EDT
Not listed No phase listed Observational

Caring for the Whole Person

NCT03034369
View directory record Official record
Conditions
Behavioral Health
Interventions
Access to Care, Depression Screening, Patient-Provider Relationship, Patient-Clinic Interactions, Stigma, Provider Continuity, Symptom Severity, Diagnoses, Social support, Preventive Screening, Inpatient Hospitalization Utilization, Inpatient Readmissions, Post-Admission follow-up
Other
Lead sponsor
Providence Health & Services
Other
Eligibility
18 Years and older
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jun 15, 2017 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

Integrated Supportive and Palliative Care for Older Adults in the ICU

NCT04921631
View directory record Official record
Conditions
Critical Illness
Interventions
Early Integration of Specialty Palliative Care with Critical Care
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
60 Years and older
Enrollment
1,091 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 1 Interventional

Brief Intervention for Suicide Risk Reduction in High Risk Adolescents

NCT02272179
View directory record Official record
Conditions
Adolescent Behavior
Interventions
As Safe As Possible, Brite, Treatment as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
12 Years to 17 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 20, 2018 · Synced Oct 8, 2026, 7:26 AM EDT
Not yet recruiting Not applicable Interventional

Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)

NCT07527273
View directory record Official record
Conditions
Aging, Depression, Cognitive Symptoms
Interventions
Depression Cognitive Training, Non-Specific Cognitive Training, tDCS (active stimulation), tDCS (sham stimulation)
Behavioral · Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
60 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 1 Interventional

Community-Based Integrated Treatment for Adolescents

NCT01667159
View directory record Official record
Conditions
Depression, Alcohol Use
Interventions
Integrated Cognitive Behavioral Therapy, Standard Care
Behavioral
Lead sponsor
Brown University
Other
Eligibility
12 Years to 18 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 23, 2018 · Synced Oct 8, 2026, 7:26 AM EDT
Recruiting Not applicable Interventional

My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

NCT05369429
View directory record Official record
Conditions
Cancer, Anxiety, Depressive Symptoms
Interventions
My Wellbeing Guide
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
6,516 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of RGH-188 (Cariprazine) in Bipolar Depression

NCT00852202
View directory record Official record
Conditions
Bipolar Depression
Interventions
cariprazine, placebo
Drug
Lead sponsor
Forest Laboratories
Industry
Eligibility
18 Years to 65 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
26
States / cities
Encino, California • Garden Grove, California • National City, California + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 23, 2018 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 4 Interventional Results available

Study Using Pregnenolone to Treat Bipolar Depression

NCT01409096
View directory record Official record
Conditions
Bipolar Disorder, Major Depressive Disorder
Interventions
Pregnenolone, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2016 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

I-COPE Study: Opioid Use and Pain Management in Older Adults

NCT04878562
View directory record Official record
Conditions
Chronic Pain, Opioids, Opioid-use Disorder
Interventions
I-COPE
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
65 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 24, 2024 · Synced Oct 8, 2026, 7:26 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Trifecta Research Study

NCT07717866
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Injury, Depression - Major Depressive Disorder, Suicidal Ideation
Interventions
Magnetic e-Resonance Therapy (MeRT), Ibogaine Hydrochloride with Magnesium Sulfate, 5-methoxy-N,N-dimethyltryptamine, Physiological Supplementation
Device · Drug
Lead sponsor
Axial Therapeutic Research
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Not applicable Interventional

vEAET for Older Veterans With Chronic Musculoskeletal Pain Pilot

NCT04552860
View directory record Official record
Conditions
Musculoskeletal Pain
Interventions
Emotional Awareness and Expression Therapy
Behavioral
Lead sponsor
VA Greater Los Angeles Healthcare System
Federal
Eligibility
60 Years to 95 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2024 · Synced Oct 8, 2026, 7:26 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Bipolar Depression Before and After Lamotrigine Treatment

NCT01042496
View directory record Official record
Conditions
Bipolar Depression
Interventions
Lamotrigine, 1H-MR
Drug · Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 8, 2016 · Synced Oct 8, 2026, 7:26 AM EDT
Not yet recruiting Not applicable Interventional

Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression

NCT07828483
View directory record Official record
Conditions
Post-traumatic Brain Injury Depression, Veteran Health
Interventions
Active Low-Intensity Focused Ultrasound (LIFU), Sham Low-Intensity Focused Ultrasound (LIFU)
Device · Other
Lead sponsor
Stanford University
Other
Eligibility
22 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 8, 2026, 7:26 AM EDT