Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 4, 2026, 8:10 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2257–2280 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Depression, Anxiety, Psilocybin-Assisted Psychotherapy, Advanced Cancer
Interventions: Psilocybin, Niacin; Drug · Other
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 25 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Adolescent Depression, Depression
Interventions: Cognitive Behavioral Therapy; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 14 Years to 18 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Anxiety Disorders and Symptoms, Depression, Bipolar Disorder, Symptoms
Interventions: Personalized MAYA Mobile App, General MAYA Mobile App; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 25 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Insomnia, Suicidal Ideation
Interventions: Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 283 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 3
States / cities: Buffalo, New York • Canandaigua, New York • Syracuse, New York

Conditions: Depression
Interventions: Nurse-led case management, Treatment as usual; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 80 Years
Enrollment: 214 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Hypoxic Ischemic Encephalopathy
Interventions: Topiramate, Placebo; Drug
Lead sponsor: Kristin R Hoffman; Other
Eligibility: Up to 6 Hours
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2022
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Depression
Interventions: Buprenorphine; Drug
Lead sponsor: University of Pittsburgh; Other
Eligibility: 50 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Major Depressive Disorder (MDD)
Interventions: ADT, Brexpiprazole; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 24
States / cities: Garden Grove, California • Temecula, California • Orlando, Florida + 21 more

Conditions: Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD)
Interventions: Spaced Transcranial Direct Current Stimulation (tDCS); Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: San Diego, California

Conditions: Depression
Interventions: IPT-AST, Enhanced IPT-AST, School counseling; Behavioral · Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 11 Years to 17 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 2
States / cities: Piscataway, New Jersey • New York, New York

Conditions: Depression, Headaches Chronic, Migraine Disorders
Interventions: CBT Individual Psychotherapy; Behavioral
Lead sponsor: University of Georgia; Other
Eligibility: 18 Years to 75 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 2
States / cities: Athens, Michigan • Detroit, Michigan

Conditions: Stress, Depression, Anxiety, Quality of Life
Interventions: Gardening, Functional Magnetic Resonance Imaging (fMRI), psychometric assessments; Other · Procedure · Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 26 Years to 49 Years · Female only
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 3
States / cities: Gainesville, Florida

Conditions: Bipolar Depression, Major Depressive Disorder
Interventions: Lumateperone, Placebos; Drug
Lead sponsor: Intra-Cellular Therapies, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 488 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 13
States / cities: Garden Grove, California • Oceanside, California • Sherman Oaks, California + 10 more

Conditions: Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Interventions: Ketamine; Drug
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Recurrent Major Depressive Disorder With Atypical Features
Interventions: betahistine dihydrochloride; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Depression
Interventions: Online- Yoga-based Intervetion, Online- BA; Other · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 520 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Advanced Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Carcinoma, Stage III Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8
Interventions: Bright White Light Therapy, Combination Drug Therapy, Electronic Health Record Review, Quality-of-Life Assessment, Questionnaire Administration; Procedure · Drug · Other
Lead sponsor: City of Hope Medical Center; Other
Eligibility: 60 Years and older · Male only
Enrollment: 210 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Duarte, California

Conditions: Major Depression
Interventions: Risperidone; Drug
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 89 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mental Health Wellness 1
Interventions: Early Adolescent Skills for Emotions EASE); Behavioral
Lead sponsor: International Rescue Committee; Other
Eligibility: 10 Years to 14 Years
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
Interventions: Cell Therapy; Other
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years to 85 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2018
U.S. locations: 2
States / cities: Bethesda, Maryland

Conditions: Major Depressive Disorder
Interventions: Interactive voice messaging or Interactive voice messaging + psycho ed materials; Behavioral
Lead sponsor: Kaiser Permanente; Other
Eligibility: 21 Years to 75 Years
Enrollment: 6,058 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Depression
Interventions: Drug Abilify; Drug
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Depressive Disorder, Treatment-Resistant
Interventions: Esketamine, Placebo, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant), Sertraline (Oral Antidepressant), Venlafaxine Extended Release (XR) (Oral Antidepressant); Drug
Lead sponsor: Janssen Research & Development, LLC; Industry
Eligibility: 18 Years to 64 Years
Enrollment: 719 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 53
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Anaheim, California + 50 more

Conditions: Bipolar II Disorder, Bipolar II Disorder, Most Recent Episode Major Depressive
Interventions: Device: Stimulation-ON, Device: Stimulation-OFF, Device: Stimulation -ON Active Control; Device
Lead sponsor: Andrew Krystal; Other
Eligibility: 22 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2035
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Predictors of Response to Treatment for Depression

Personalized Mobile Cognitive Behavioral Therapy Application

RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts

Nurse-led Case Management for Diabetes and Cardiovascular Disease Patients With Depression

Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy

Buprenorphine for Late-Life Treatment Resistant Depression

Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy

Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression: A Home-Based Feasibility and Safety Study

Comparison of Three Therapy-Based Interventions for Preventing Depression in Adolescents

CBT Depression Intervention for Co-Occurring Chronic Headache

Effect of Gardening on Brain Activity

Clinical Trial Evaluating Lumateperone Monotherapy in the Treatment of Bipolar Depression or Major Depressive Disorder

Ketamine Infusions for PTSD and Treatment-Resistant Depression

Pilot Study of Betahistine Dihydrochloride in the Treatment of Major Depression With Atypical Features

Comparing Behavior Therapy and Yoga for Treating Depression Among Adults

Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

Use of Risperidone in ECT for Treatment Resistant Depression

Early Adolescent Skills for Emotions Tanzania Pilot

Stem Cell Injection to Treat Heart Damage During Open Heart Surgery

Antidepressant Adherence Via AD_IVR

Aripiprazole as Augmentation for TRD

A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression