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ClinicalTrials.gov public records Last synced Nov 4, 2026, 10:39 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 2305–2328 of 3,107 matching trials from the live ClinicalTrials.gov search.

Filters: Intervention: Treatment of depression Clear all

Conditions: Major Depressive Disorder
Interventions: Near-infrared radiation via Transcranial LED Therapy, Sham device; Device
Lead sponsor: Paolo Cassano; Other
Eligibility: 18 Years to 65 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 2
States / cities: Boston, Massachusetts • Chelsea, Massachusetts

Conditions: Major Depressive Disorder
Interventions: Active computer-based training, Inert computer training; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 18 Years to 55 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Postpartum Depression
Interventions: WB001, ED001; Device
Lead sponsor: Woebot Health; Industry
Eligibility: 22 Years to 45 Years · Female only
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 8
States / cities: Lafayette, California • Santa Ana, California • DeLand, Florida + 5 more

Conditions: Anhedonia, Virtual Reality, Depression, Mood Disorders, Stress, Anxiety
Interventions: Positive Virtual Reality Training; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 40 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Depression
Interventions: PST-MCI/AD Caregiving, NT-MCI/AD Caregiving; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2011
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Epilepsy, Major Depressive Disorder (MDD)
Interventions: Extended-release bupropion (HCl); Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years and older
Enrollment: 268 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 24
States / cities: Beverly Hills, California • Sherman Oaks, California • Temecula, California + 21 more

Conditions: Major Depressive Disorder
Interventions: Transcranial Magnetic Stimulation (TMS) - Fully Individualized iTBS, Transcranial Magnetic Stimulation (TMS) - targeted-iTBS, Transcranial Magnetic Stimulation (TMS) - Standard-iTBS; Device
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years to 80 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Chronic Low-back Pain, Depression
Interventions: Psilocybin, Methylphenidate; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Depression, Anxiety
Interventions: TDCS - transcranial direct current stimulation; Device
Lead sponsor: Jay Fournier; Other
Eligibility: 18 Years to 30 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depressive Disorder, Major
Interventions: rTMS therapy; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Bipolar Disorder, Bipolar Depression
Interventions: N-acetylcysteine, Minocycline, Placebo; Dietary Supplement · Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Post Traumatic Stress Disorder (PTSD)
Interventions: Transcranial Magnetic Stimulation; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder
Interventions: Duloxetine; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2002
U.S. locations: 9
States / cities: Trumbull, Connecticut • Lafayette, Indiana • Gaithersburg, Maryland + 6 more

Conditions: Major Depressive Disorder, Insulin Resistance
Interventions: Pioglitazone, Sugar Pill; Drug
Lead sponsor: Stanford University; Other
Eligibility: 20 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Depression
Interventions: Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 80 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Charleston, South Carolina

Conditions: Bipolar Depression
Interventions: Lumateperone (ITI-007), Placebo; Drug
Lead sponsor: Intra-Cellular Therapies, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 529 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 42
States / cities: Rogers, Arkansas • Cerritos, California • Costa Mesa, California + 39 more

Conditions: Major Depressive Disorder
Interventions: vilazodone, placebo; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 481 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 9
States / cities: Newport Beach, California • Bradenton, Florida • Atlanta, Georgia + 6 more

Conditions: Depressive Disorder in Mothers
Interventions: In-Home Cognitive Behavioral Therapy, Present-Centered Therapy; Behavioral
Lead sponsor: Children's Hospital Medical Center, Cincinnati; Other
Eligibility: 16 Years to 45 Years · Female only
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2017
U.S. locations: 1
States / cities: Cincinnati, Ohio

Conditions: Bipolar Disorder
Interventions: Omega-3 Supplementation, Psychoeducational Psychotherapy (PEP), Placebo; Drug · Behavioral · Other
Lead sponsor: L. Eugene Arnold; Other
Eligibility: 7 Years to 14 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Major Depressive Disorder, Anxiety
Interventions: Brexpiprazole; Drug
Lead sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 21
States / cities: Tuscon, Arizona • Garden Grove, California • Oceanside, California + 18 more

Conditions: Depression
Interventions: Depression Decision Aid; Behavioral
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 21 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Opioid-use Disorder, Anxiety, Depression, Stress Related Disorder
Interventions: M-ROCC; Behavioral
Lead sponsor: Cambridge Health Alliance; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Somerville, Massachusetts

Conditions: Generalized Anxiety Disorder
Interventions: Cariprazine 0.75 mg/day, Cariprazine 1.5 mg/day, Cariprazine 3.0 mg/day, Placebo; Drug · Other
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 36
States / cities: Little Rock, Arkansas • Colton, California • Costa Mesa, California + 29 more

Conditions: Depression, Healthy
Interventions: Quetiapine; Drug
Lead sponsor: University of Cincinnati; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2012
U.S. locations: 1
States / cities: Cincinnati, Ohio

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Transcranial Laser Therapy for Major Depressive Disorder

Testing the Effectiveness of a Computer-based Program for Depression

[Study Evaluating the Efficacy and Safety of a Digital Therapeutic as an Adjunct to TAU in Postpartum Depression]

Mobile Virtual Positive Experiences for Anhedonia

Prevention of Depression in Spouses of People With Cognitive Impairment

Lethargic Depression Study

Frequency and E-field Enhancement of ITBS for Depression (FREED)

Psilocybin in Chronic Low Back Pain and Depression

Modulating Default Mode Network Function: A Transcranial Direct Current Stimulation (TDCS) Pilot Study

Biomarkers of Depression and Treatment Response

A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression

Targeted Accelerated TMS for Post-Traumatic Stress Disorder

Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression

Pioglitazone in Patients With Mood Disorders

Mindfulness Training During Accelerated TMS for Depression

Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression

Randomized, Double-Blind, Placebo Controlled Study of Vilazodone's Efficacy, Safety, and Biomarkers of Response in Major Depressive Disorder (MDD)

Treatment of Maternal Depression in Home Visitation: Mother and Child Impacts

Omega-3 and Therapy Study for Childhood Bipolar Disorder- Not Otherwise Specified

Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms

Depression Decision Aid: Feasibility Pilot

MINDFUL-OBOT: Effect of Mindfulness on Opioid Use and Anxiety During Primary Care Buprenorphine Treatment

A Study To Assess Adverse Events and Change in Disease Activity With Oral Cariprazine When Added to Antidepressant Therapies (ADTs) Compared to Placebo in Adult Participants With Generalized Anxiety Disorder (GAD) Who Have Had an Inadequate Response to ADTs Alone

Quetiapine in Melancholic Depression