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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Trier Social Stress Test (TSST) Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Melatonin on Cardiovascular and Thermoregulatory Responses to Stress

NCT07138443
View directory record Official record
Conditions
Stress, Mental Stress
Interventions
Melatonin 3 MG Oral Tablet, Placebo Oral Tablet
Dietary Supplement
Lead sponsor
Baylor University
Other
Eligibility
18 Years to 70 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Terminated Early Phase 1 Interventional Accepts healthy volunteers

Internalized Stress in Relation to Alcohol Consumption

NCT06091189
View directory record Official record
Conditions
Stress, Physiological, Ethanol Intoxication, Distress, Emotional
Interventions
Relevant Trier Social Stressor Test (TSST), Ethanol, Placebo Trier Social Stressor Test (TSST), Placebo Beverage, Irrelevant Trier Social Stressor Test (TSST)
Behavioral · Drug
Lead sponsor
Texas Tech University
Other
Eligibility
21 Years to 29 Years
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Adverse Adolescent Pathways to Substance Use

NCT06977178
View directory record Official record
Conditions
Anxiety, Adolescent Development, Substance Use
Interventions
Trier Social Stress Test
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
12 Years to 14 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

NCT07244809
View directory record Official record
Conditions
Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function, Oxidative Stress, Psychosocial Influence on Cardiovascular Disease
Interventions
Mitoquinone mesylate (MitoQ), Placebo
Dietary Supplement
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mental Stress & Diesel Exhaust on Cardiovascular Health

NCT03467997
View directory record Official record
Conditions
Blood Pressure, Inflammation, Catecholamines
Interventions
Trier social stress test, Diesel exhaust
Behavioral · Other
Lead sponsor
University of Washington
Other
Eligibility
22 Years to 49 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 4, 2018 · Synced Sep 28, 2026, 9:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls

NCT03450135
View directory record Official record
Conditions
Adolescent Development, Stress, Emotional Disturbances
Interventions
Trier Social Stress Test, Emotional go/no-go task
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
11 Years to 14 Years · Female only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Mitochondrial Stress, Brain Imaging, and Epigenetics

NCT04831424
View directory record Official record
Conditions
Mitochondrial Diseases
Interventions
Trier social stress test
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 60 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stress-induced Drinking in Emerging Adults: the Role of Trauma History

NCT01363180
View directory record Official record
Conditions
Trauma, Posttraumatic Stress Disorder
Interventions
Trier Social Stress Test (TSST), No stress condition
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 30 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2018 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stress-induced Scratching in Healthy and AD

NCT04174651
View directory record Official record
Conditions
Healthy, Atopic Dermatitis
Interventions
Trier Social Stress Test (TSST), Landscape Video
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 59 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 9, 2022 · Synced Sep 28, 2026, 9:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stress and Coping in Caregivers of Younger Patients With Cancer

NCT02725385
View directory record Official record
Conditions
Anxiety, Depression
Interventions
Laboratory Biomarker Analysis, Physiologic Testing, Questionnaire Administration
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 1, 2018 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

MicroRNA Correlates of Childhood Maltreatment and Suicidality

NCT04923685
View directory record Official record
Conditions
Major Depressive Disorder, Suicidal Ideation
Interventions
Trier Social Stress Test
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 60 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Affect-based Impulsivity in Borderline Personality Disorder

NCT06880640
View directory record Official record
Conditions
Borderline Personality Disorder (BPD), Healthy Controls Group - Age and Sex-matched
Interventions
Stress Induction
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Maternal Emotions and Diet in Pregnancy

NCT03278392
View directory record Official record
Conditions
Pregnancy Related, Stress, Psychological, Glucose Intolerance During Pregnancy
Interventions
Trier Social Stress Test, Placebo Non-stress task
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 12, 2021 · Synced Sep 28, 2026, 9:37 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Essential Oil Inhalation and Acute Stress Response in Healthy Adults

NCT07473544
View directory record Official record
Conditions
Psychological Stress
Interventions
Essential Oil Inhalation, Placebo Aroma Stick
Other
Lead sponsor
dōTERRA International
Industry
Eligibility
18 Years to 45 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Exploring the Decision to Drink (More) Alcohol Following Manipulations of Stress and Social Context

NCT07390084
View directory record Official record
Conditions
Psychological Stress, Social Interaction
Interventions
Stress, Social Context
Other
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 50 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)

NCT03459456
View directory record Official record
Conditions
OCD, Obsessive-Compulsive Disorder
Interventions
Provocation OC task (Provoc), Trier Social Stress Test (TSST), Exposure provocation task
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 70 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
3
States / cities
Pittsburgh, Pennsylvania • Providence, Rhode Island • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Results available

Stress and CKD Among African Americans

NCT03387319
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Racialized Stressful Event Recall, Non-Racialized Stressful Event Recall
Behavioral
Lead sponsor
Emory University
Other
Eligibility
25 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 11, 2020 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Results available

Stress-Reactivity and Cannabis Use in Cannabis-Using Older Adults

NCT05072795
View directory record Official record
Conditions
Cannabis Use
Interventions
Trier Social Stress Task (TSST)
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
50 Years to 80 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2024 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional

Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease

NCT05795634
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer Disease
Interventions
Trier Social Stress Test
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Breathing on Cognitive Performance and Stress

NCT06986135
View directory record Official record
Conditions
Stress, Acute Stress Reaction, Breathing Techniques, Cognitive Performance
Interventions
Box Breathing, Prolonged Exhalation, Normal Breathing
Other
Lead sponsor
Texas State University
Other
Eligibility
18 Years to 39 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Marcos, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Transcutaneous Vagus Nerve Stimulation (tVNS) and Stress Regulation During Performance Tasks

NCT07470229
View directory record Official record
Conditions
Stress Response
Interventions
Transcutaneous Vagus Nerve Stimulation (tVNS), Evaluative Stress Task
Device · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition

NCT03592238
View directory record Official record
Conditions
Exercise, Cognition
Interventions
Aerobic Exercise Intervention, Trier Social Stress Test for Children, Seated Rest
Other
Lead sponsor
Northeastern University
Other
Eligibility
9 Years to 10 Years
Enrollment
297 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 28, 2026, 9:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Stress Reactivity Study in Adolescents

NCT03997149
View directory record Official record
Conditions
Stress, Eating Behavior
Interventions
Acute Laboratory Stressor, Low affect video
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 19 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Sep 28, 2026, 9:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

My Life and My Experiences Project

NCT06821178
View directory record Official record
Conditions
Stress and Memory in Adolescence
Interventions
Acute stress manipulation
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
12 Years to 18 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Sep 28, 2026, 9:37 PM EDT