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ClinicalTrials.gov public records Last synced Oct 20, 2026, 3:14 PM EDT

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Showing 1–24 of 40 matching trials from the live ClinicalTrials.gov search.
Filters: Intervention: Trigeminal Nerve Stimulation Clear all
Completed No phase listed Observational

Observational Study of the the Use of a Trigeminal Vagal Nerve Stimulator in the Routine Care of Native Americans With Diabetic Neuropathy Pain. Pain Scores, Drug Use and Glucose Measurements Will be Assessed

NCT07025356
View directory record Official record
Conditions
Diabetic Neuropathy With Neurologic Complication
Interventions
Implantation of a trigeminal Vagus cervical nerve stimulator system, Implantation of a neurostimulator system for trigeminal vagal cervical nerve stimulation
Drug · Device
Lead sponsor
Vagus Nerve Society
Other
Eligibility
18 Years to 89 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Pine Ridge, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Phase 2 Interventional

Trigeminal Nerve Stimulation for Depression: Dose Finding

NCT01343563
View directory record Official record
Conditions
Depression
Interventions
Trigeminal Nerve Stimulation
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting No phase listed Observational

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

NCT06788977
View directory record Official record
Conditions
Pregnancy, Migraine, Headache, Postpartum, Depression, Anxiety
Interventions
external Trigeminal Nerve Stimulation
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 44 Years · Female only
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Darien, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts

NCT03621735
View directory record Official record
Conditions
Tinnitus
Interventions
Burst-SCS/sham SCS, Sham SCS/Burst-SCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 30, 2023 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional

tAN for PTSD and OUD in Buprenorphine Therapy

NCT06130501
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions
Sparrow Ascent tAN, Sparrow Ascent Active Sham
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cape Girardeau, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Phase 2 Interventional Results available

External Trigeminal Nerve Stimulation for Epilepsy

NCT01159431
View directory record Official record
Conditions
Epilepsy, Seizure Disorders
Interventions
Trigeminal Nerve Stimulation
Device
Lead sponsor
Olive View-UCLA Education & Research Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Los Angeles, California • Sylmar, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

NCT06100172
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Lumbar Spine Injury
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN), Sham Control Device
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Phase 1 Interventional

Trigeminal Nerve Stimulation for Post Traumatic Stress Disorder (PTSD) and Depression

NCT01335217
View directory record Official record
Conditions
Depression, Post-traumatic Stress Disorder
Interventions
Transcutaneous Electrical Nerve Stimulator (TENS)
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury

NCT06467708
View directory record Official record
Conditions
TBI (Traumatic Brain Injury)
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury

NCT02158494
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Balance and Gait Training using neurostimulation modulation., Sham Device
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 3, 2019 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Trigeminal Nerve Stimulation for ADHD

NCT02155608
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder (ADHD)
Interventions
Active eTNS, Sham eTNS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
8 Years to 12 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2019 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)

NCT04279522
View directory record Official record
Conditions
MDD
Interventions
Relivion®DP- Active, Relivion®DP- Sham
Device
Lead sponsor
Neurolief Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
12
States / cities
La Jolla, California • Los Angeles, California • Miami Lakes, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2025 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

NCT03564353
View directory record Official record
Conditions
Healthy Adults
Interventions
tDCS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Four-week Open-trial Extension TNS for ADHD

NCT03870737
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder (ADHD)
Interventions
Active TNS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
8 Years to 12 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Abortive Treatment of Migraine With the Cefaly® Abortive Program Device

NCT03217968
View directory record Official record
Conditions
Migraine
Interventions
Cefaly® Abortive Program device
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2018 · Synced Oct 20, 2026, 3:14 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Investigating Accelerated Learning in Healthy Subjects: Trigeminal Nerve Stimulation

NCT03138590
View directory record Official record
Conditions
Healthy Adults
Interventions
Transcranial Direct Current Stimulation- Neuroconn DC Stimulator PLUS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Oct 20, 2026, 3:14 PM EDT
Not yet recruiting Not applicable Interventional

Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC

NCT07718984
View directory record Official record
Conditions
Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)
Interventions
tAN plus PEPC, sham plus PEPC
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Palpatory Neuromodulation of the Trigeminal Nerve for Tenderness in the Posterior Neck Musculature

NCT04936659
View directory record Official record
Conditions
Neuromodulation, Neck Pain
Interventions
neuromodulation
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
18 Years to 65 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2021 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

NCT07090668
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
tAN device
Device
Lead sponsor
Emory University
Other
Eligibility
7 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Phase 2 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

NCT07689773
View directory record Official record
Conditions
Olfactory Impairment
Interventions
Trigeminal Nerve Stimulation-enhanced Smell Training
Combination Product
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Open-trial on the Prevention of Chronic Migraines With the CEFALY Device

NCT02342743
View directory record Official record
Conditions
Migraine
Interventions
CEFALY
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Phase 2Phase 3 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

NCT05855369
View directory record Official record
Conditions
Smell Dysfunction, Olfactory Disorder, Long COVID
Interventions
Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST), Placebo Smell Training (PBO)
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Oct 20, 2026, 3:14 PM EDT
Completed Not applicable Interventional Results available

Acute Treatment of Migraine With e-TNS

NCT02590939
View directory record Official record
Conditions
Migraine
Interventions
CEFALY Active, CEFALY Placebo
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
New Haven, Connecticut • Lenexa, Kansas • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 20, 2026, 3:14 PM EDT
Recruiting Not applicable Interventional

Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure

NCT06847165
View directory record Official record
Conditions
Fetal Alcohol Spectrum Disorders, Attention Deficit Hyperactivity Disorder
Interventions
Trigeminal Nerve Stimulation (TNS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
8 Years to 12 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 20, 2026, 3:14 PM EDT