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Showing 1–24 of 39 matching trials from the live ClinicalTrials.gov search.
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Filters: Intervention: Trigeminal Nerve Stimulation Clear all
Completed Not applicable Interventional Results available

Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts

NCT03621735
View directory record Official record
Conditions
Tinnitus
Interventions
Burst-SCS/sham SCS, Sham SCS/Burst-SCS
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2023 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of a Device to Reduce Motion Sickness and Spatial Disorientation

NCT06892340
View directory record Official record
Conditions
Motion Sickness
Interventions
Transcutaneous Auricular Neurostimulation device
Device
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 50 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting No phase listed Observational

External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

NCT06788977
View directory record Official record
Conditions
Pregnancy, Migraine, Headache, Postpartum, Depression, Anxiety
Interventions
external Trigeminal Nerve Stimulation
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 44 Years · Female only
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Darien, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

External Trigeminal Nerve Stimulation for Children With ASD + ADHD to Reduce Elevated Symptoms

NCT07214545
View directory record Official record
Conditions
Attention Deficit Disorder With Hyperactivity (ADHD), Autism Spectrum Disorder (ASD)
Interventions
Trigeminal Nerve Stimulation, Sham Trigeminal Nerve Stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
7 Years to 14 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Auditory-somatosensory Stimulation to Alleviate Tinnitus

NCT02974543
View directory record Official record
Conditions
Tinnitus
Interventions
Sham Treatment: unimodal auditory stimulation, Active Treatment: Bimodal auditory-somatosensory stimulation
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Neuromodulation for Post-Traumatic Stress Disorder

NCT02377089
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Trigeminal Nerve Stimulation, Placebo
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Acute Treatment of Migraine With e-TNS

NCT02590939
View directory record Official record
Conditions
Migraine
Interventions
CEFALY Active, CEFALY Placebo
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
New Haven, Connecticut • Lenexa, Kansas • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Phase 2Phase 3 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)

NCT05855369
View directory record Official record
Conditions
Smell Dysfunction, Olfactory Disorder, Long COVID
Interventions
Trigeminal Nerve Stimulation (TNS), Active Smell Training (ST), Placebo Smell Training (PBO)
Device · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 65 Years
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

NCT07090668
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
tAN device
Device
Lead sponsor
Emory University
Other
Eligibility
7 Years to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation After Lumbar Surgery

NCT06100172
View directory record Official record
Conditions
Pain, Postoperative, Opioid Use, Lumbar Spine Injury
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN), Sham Control Device
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Trigeminal Nerve Stimulation for ADHD

NCT02155608
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder (ADHD)
Interventions
Active eTNS, Sham eTNS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
8 Years to 12 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2019 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Abortive Treatment of Migraine With the Cefaly® Abortive Program Device

NCT03217968
View directory record Official record
Conditions
Migraine
Interventions
Cefaly® Abortive Program device
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 6, 2018 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury

NCT02158494
View directory record Official record
Conditions
Brain Injuries, Traumatic
Interventions
Balance and Gait Training using neurostimulation modulation., Sham Device
Device
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury

NCT06467708
View directory record Official record
Conditions
TBI (Traumatic Brain Injury)
Interventions
Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure

NCT06847165
View directory record Official record
Conditions
Fetal Alcohol Spectrum Disorders, Attention Deficit Hyperactivity Disorder
Interventions
Trigeminal Nerve Stimulation (TNS)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
8 Years to 12 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Phase 2 Interventional

Trigeminal Nerve Stimulation for Depression: Dose Finding

NCT01343563
View directory record Official record
Conditions
Depression
Interventions
Trigeminal Nerve Stimulation
Procedure
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 5, 2013 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Not applicable Interventional

Vagus Nerve Stimulation in Patients in Comatose State

NCT07719595
View directory record Official record
Conditions
Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
Interventions
Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
Device
Lead sponsor
Sima Mofakham
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Recruiting Phase 2 Interventional

Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label

NCT07689773
View directory record Official record
Conditions
Olfactory Impairment
Interventions
Trigeminal Nerve Stimulation-enhanced Smell Training
Combination Product
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Results available

A Phase III Trial of e-TNS for the Acute Treatment of Migraine

NCT03465904
View directory record Official record
Conditions
Migraine
Interventions
Verum Cefaly® Abortive Program device, Sham Cefaly® Abortive Program device
Device
Lead sponsor
Cefaly Technology
Industry
Eligibility
18 Years to 65 Years
Enrollment
607 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
10
States / cities
Tempe, Arizona • Encino, California • New Haven, Connecticut + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2024 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional

tAN for PTSD and OUD in Buprenorphine Therapy

NCT06130501
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Opioid Use Disorder
Interventions
Sparrow Ascent tAN, Sparrow Ascent Active Sham
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cape Girardeau, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 3, 2026, 11:04 PM EDT
Active, not recruiting Not applicable Interventional

Trigeminal Nerve Stimulation of the Treatment of Epilepsy

NCT07220161
View directory record Official record
Conditions
Epilepsy (Treatment Refractory)
Interventions
Trigeminal nerve stimulation
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating Memory in Healthy Subjects Using Transcranial Direct Current Stimulation

NCT03564353
View directory record Official record
Conditions
Healthy Adults
Interventions
tDCS
Device
Lead sponsor
The University of Texas at Dallas
Other
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Richardson, Texas
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Sep 3, 2026, 11:04 PM EDT
Completed Phase 2 Interventional Results available

External Trigeminal Nerve Stimulation for Epilepsy

NCT01159431
View directory record Official record
Conditions
Epilepsy, Seizure Disorders
Interventions
Trigeminal Nerve Stimulation
Device
Lead sponsor
Olive View-UCLA Education & Research Institute
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
2
States / cities
Los Angeles, California • Sylmar, California
Source: ClinicalTrials.gov public record
Updated Jun 2, 2013 · Synced Sep 3, 2026, 11:04 PM EDT
Completed No phase listed Observational

Observational Study of the the Use of a Trigeminal Vagal Nerve Stimulator in the Routine Care of Native Americans With Diabetic Neuropathy Pain. Pain Scores, Drug Use and Glucose Measurements Will be Assessed

NCT07025356
View directory record Official record
Conditions
Diabetic Neuropathy With Neurologic Complication
Interventions
Implantation of a trigeminal Vagus cervical nerve stimulator system, Implantation of a neurostimulator system for trigeminal vagal cervical nerve stimulation
Drug · Device
Lead sponsor
Vagus Nerve Society
Other
Eligibility
18 Years to 89 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Pine Ridge, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Sep 3, 2026, 11:04 PM EDT